User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Induced pluripotent stem cell potential in medicine, specifically focused on reproductive medicine

Primary tabs

download
  • Open access
  • PDF
  • 354.73 K
Wyns, Christine [UCL] Botman, Olivier [UCL]

Since 2006, several laboratories have proved that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs). iPSCs have enormous potential in stem cell biology as they can give rise to numerous cell lineages, including the three germ layers. In this review, we discuss past and recent advances in human iPSCs used for modeling diseases in vitro, screening drugs to test new treatments, and autologous cell and tissue regenerative therapies, with a special focus on reproductive medicine applications. While this latter field of research is still in its infancy, it holds great promise for investigating germ cell development and studying the genetic and physiopathological mechanisms of infertility. A major cause of infertility is the absence of germ cells in the testes, mainly due to genetic background or as a consequence of gonadotoxic treatments. For these patients, no effective fertility restoration strategy has so far been identified. The derivation of germ cells from iPSCs represents an alternative source of stem cells able to differentiate into spermatozoa. Lessons learned from animal models as well as studies on human iPSCs for reproductive purposes are reviewed.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès mixte
Publication date 2014
Language Anglais
Journal information "Frontiers in surgery" - Vol. 1, no. 5, p. 1-10 (2014)
Peer reviewed yes
Publisher Frontiers Media SA (Lausanne, Switzerland)
issn 2296-875x
e-issn 2296-875x
Publication status Publié
Affiliations UCL - SSS/IREC/GYNE - Pôle de Gynécologie
UCL - (SLuc) Service de gynécologie et d'andrologie
Keywords Human induced pluripotent stem cells ; Primordial germ cells ; Embryonic cells ; Infertility
Links
  1. Thomson J. A., Embryonic Stem Cell Lines Derived from Human Blastocysts, 10.1126/science.282.5391.1145
  2. Sermon K.D., Simon C., Braude P., Viville S., Borstlap J., Veiga A., Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg, 10.1093/humrep/dep062
  3. Swijnenburg Rutger-Jan, Schrepfer Sonja, Cao Feng, Pearl Jeremy I., Xie Xiaoyan, Connolly Andrew J., Robbins Robert C., Wu Joseph C., In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Immune Rejection Following Transplantation, 10.1089/scd.2008.0091
  4. Swijnenburg R.-J., Schrepfer S., Govaert J. A., Cao F., Ransohoff K., Sheikh A. Y., Haddad M., Connolly A. J., Davis M. M., Robbins R. C., Wu J. C., Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts, 10.1073/pnas.0805802105
  5. Takahashi Kazutoshi, Yamanaka Shinya, Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, 10.1016/j.cell.2006.07.024
  6. Niwa Hitoshi, Smith Austin G., Miyazaki Jun-ichi, 10.1038/74199
  7. Avilion A. A., Multipotent cell lineages in early mouse development depend on SOX2 function, 10.1101/gad.224503
  8. Cartwright P., LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism, 10.1242/dev.01670
  9. Li Y., Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4, 10.1182/blood-2004-07-2681
  10. Okita Keisuke, Ichisaka Tomoko, Yamanaka Shinya, Generation of germline-competent induced pluripotent stem cells, 10.1038/nature05934
  11. Takahashi Kazutoshi, Tanabe Koji, Ohnuki Mari, Narita Megumi, Ichisaka Tomoko, Tomoda Kiichiro, Yamanaka Shinya, Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, 10.1016/j.cell.2007.11.019
  12. Taapken Seth M, Nisler Benjamin S, Newton Michael A, Sampsell-Barron Tori L, Leonhard Kimberly A, McIntire Erik M, Montgomery Karen D, Karotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells, 10.1038/nbt.1835
  13. Nichols Jennifer, Zevnik Branko, Anastassiadis Konstantinos, Niwa Hitoshi, Klewe-Nebenius Daniela, Chambers Ian, Schöler Hans, Smith Austin, Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4, 10.1016/s0092-8674(00)81769-9
  14. Lee Gabsang, Papapetrou Eirini P., Kim Hyesoo, Chambers Stuart M., Tomishima Mark J., Fasano Christopher A., Ganat Yosif M., Menon Jayanthi, Shimizu Fumiko, Viale Agnes, Tabar Viviane, Sadelain Michel, Studer Lorenz, Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs, 10.1038/nature08320
  15. Anderson Sylvia L, Qiu Jinsong, Rubin Berish Y, EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia, 10.1016/j.bbrc.2003.09.019
  16. Itzhaki Ilanit, Maizels Leonid, Huber Irit, Gepstein Amira, Arbel Gil, Caspi Oren, Miller Liron, Belhassen Bernard, Nof Eyal, Glikson Michael, Gepstein Lior, Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells, 10.1016/j.jacc.2012.02.066
  17. Hanna J., Wernig M., Markoulaki S., Sun C.-W., Meissner A., Cassady J. P., Beard C., Brambrink T., Wu L.-C., Townes T. M., Jaenisch R., Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin, 10.1126/science.1152092
  18. Wernig Marius, Meissner Alexander, Cassady John P., Jaenisch Rudolf, c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts, 10.1016/j.stem.2007.12.001
  19. Wernig M., Zhao J.-P., Pruszak J., Hedlund E., Fu D., Soldner F., Broccoli V., Constantine-Paton M., Isacson O., Jaenisch R., Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease, 10.1073/pnas.0801677105
  20. Li Wen, Wang Xianming, Fan Wenxia, Zhao Ping, Chan Yau-Chi, Chen Shen, Zhang Shiqiang, Guo Xiangpeng, Zhang Ya, Li Yanhua, Cai Jinglei, Qin Dajiang, Li Xingyan, Yang Jiayin, Peng Tianran, Zychlinski Daniela, Hoffmann Dirk, Zhang Ruosi, Deng Kang, Ng Kwong-Man, Menten Bjorn, Zhong Mei, Wu Jiayan, Li Zhiyuan, Chen Yonglong, Schambach Axel, Tse Hung-Fat, Pei Duanqing, Esteban Miguel A., Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes, 10.1093/hmg/ddr435
  21. Rodrigo Sander F., van Ramshorst Jan, Hoogslag Georgette E., Boden Helèn, Velders Matthijs A., Cannegieter Suzanne C., Roelofs Helene, Al Younis Imad, Dibbets-Schneider Petra, Fibbe Willem E., Zwaginga Jaap Jan, Bax Jeroen J., Schalij Martin J., Beeres Saskia L., Atsma Douwe E., Intramyocardial Injection of Autologous Bone Marrow-Derived Ex Vivo Expanded Mesenchymal Stem Cells in Acute Myocardial Infarction Patients is Feasible and Safe up to 5 Years of Follow-up, 10.1007/s12265-013-9507-7
  22. Zhang Zheng, Lin Hu, Shi Ming, Xu Ruonan, Fu Junliang, Lv Jiyun, Chen Liming, Lv Sa, Li Yuanyuan, Yu Shuangjie, Geng Hua, Jin Lei, Lau George K K, Wang Fu-Sheng, Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients : Stem cells treat liver cirrhosis, 10.1111/j.1440-1746.2011.07024.x
  23. Wang, Chin Med J (Engl), 124, 3622 (2011)
  24. Kunisada Yuya, Tsubooka-Yamazoe Noriko, Shoji Masanobu, Hosoya Masaki, Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells, 10.1016/j.scr.2011.10.002
  25. McLaren, Symp Soc Exp Biol, 38, 7 (1984)
  26. Mamsen Linn Salto, Brchner Christian Beltoft, Byskov Anne Grete, Mllgard Kjeld, The migration and loss of human primordial germ stem cells from the hind gut epithelium towards the gonadal ridge, 10.1387/ijdb.120202lm
  27. Surani M. Azim, Hayashi Katsuhiko, Hajkova Petra, Genetic and Epigenetic Regulators of Pluripotency, 10.1016/j.cell.2007.02.010
  28. Ohinata Yasuhide, Payer Bernhard, O'Carroll Dónal, Ancelin Katia, Ono Yukiko, Sano Mitsue, Barton Sheila C., Obukhanych Tetyana, Nussenzweig Michel, Tarakhovsky Alexander, Saitou Mitinori, Surani M. Azim, Blimp1 is a critical determinant of the germ cell lineage in mice, 10.1038/nature03813
  29. Yabuta Yukihiro, Kurimoto Kazuki, Ohinata Yasuhide, Seki Yoshiyuki, Saitou Mitinori, Gene Expression Dynamics During Germline Specification in Mice Identified by Quantitative Single-Cell Gene Expression Profiling1, 10.1095/biolreprod.106.053686
  30. Li Chunliang, Yu Hongyao, Ma Yu, Shi Guilai, Jiang Jing, Gu Junjie, Yang Ying, Jin Shibo, Wei Zhe, Jiang Hua, Li Jinsong, Jin Ying, Germline-Competent Mouse-Induced Pluripotent Stem Cell Lines Generated on Human Fibroblasts without Exogenous Leukemia Inhibitory Factor, 10.1371/journal.pone.0006724
  31. Eguizabal C., Montserrat N., Vassena R., Barragan M., Garreta E., Garcia-Quevedo L., Vidal F., Giorgetti A., Veiga A., Belmonte J. C. Izpisua, Complete Meiosis from Human Induced Pluripotent Stem Cells, 10.1002/stem.672
  32. Hirai Hiroyuki, Firpo Meri, Kikyo Nobuaki, Establishment of LIF-Dependent Human iPS Cells Closely Related to Basic FGF-Dependent Authentic iPS Cells, 10.1371/journal.pone.0039022
  33. Yang S., Bo J., Hu H., Guo X., Tian R., Sun C., Zhu Y., Li P., Liu P., Zou S., Huang Y., Li Z., Derivation of male germ cells from induced pluripotent stem cells in vitro and in reconstituted seminiferous tubules, 10.1111/j.1365-2184.2012.00811.x
  34. Saiti Deshira, Lacham-Kaplan Orly, Density gradients for the isolation of germ cells from embryoid bodies, 10.1016/s1472-6483(10)60489-0
  35. Zhu Yong, Hu Hong-Liang, Li Peng, Yang Shi, Zhang Wei, Ding Hui, Tian Ru-Hui, Ning Ye, Zhang Ling-Ling, Guo Xi-Zhi, Shi Zhan-Ping, Li Zheng, He Zuping, Generation of male germ cells from induced pluripotent stem cells (iPS cells): an in vitro and in vivo study, 10.1038/aja.2012.3
  36. Aoi T., Yae K., Nakagawa M., Ichisaka T., Okita K., Takahashi K., Chiba T., Yamanaka S., Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells, 10.1126/science.1154884
  37. Hayashi Katsuhiko, Ohta Hiroshi, Kurimoto Kazuki, Aramaki Shinya, Saitou Mitinori, Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells, 10.1016/j.cell.2011.06.052
  38. Easley Charles A., Phillips Bart T., McGuire Megan M., Barringer Jennifer M., Valli Hanna, Hermann Brian P., Simerly Calvin R., Rajkovic Aleksander, Miki Toshio, Orwig Kyle E., Schatten Gerald P., Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells, 10.1016/j.celrep.2012.07.015
  39. Medrano Jose V., Ramathal Cyril, Nguyen Ha N., Simon Carlos, Reijo Pera Renee A., Divergent RNA-binding Proteins, DAZL and VASA, Induce Meiotic Progression in Human Germ Cells Derived in Vitro, 10.1002/stem.1012
  40. Panula Sarita, Medrano Jose V., Kee Kehkooi, Bergström Rosita, Nguyen Ha Nam, Byers Blake, Wilson Kitchener D., Wu Joseph C., Simon Carlos, Hovatta Outi, Reijo Pera Renee A., Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells, 10.1093/hmg/ddq520
  41. Kee Kehkooi, Angeles Vanessa T., Flores Martha, Nguyen Ha Nam, Reijo Pera Renee A., Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation, 10.1038/nature08562
  42. Park Tae Sub, Galic Zoran, Conway Anne E., Lindgren Anne, van Handel Benjamin J., Magnusson Mattias, Richter Laura, Teitell Michael A., Mikkola Hanna K. A., Lowry William E., Plath Kathrin, Clark Amander T., Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells, 10.1002/stem.13
  43. Ma Yu, Li Chunliang, Gu Junjie, Tang Fan, Li Chun, Li Peng, Ping Ping, Yang Shi, Li Zheng, Jin Ying, Aberrant Gene Expression Profiles in Pluripotent Stem Cells Induced from Fibroblasts of a Klinefelter Syndrome Patient, 10.1074/jbc.m112.380204
  44. Hubner K., Derivation of Oocytes from Mouse Embryonic Stem Cells, 10.1126/science.1083452
  45. Lacham-Kaplan Orly, Chy Hun, Trounson Alan, Testicular Cell Conditioned Medium Supports Differentiation of Embryonic Stem Cells into Ovarian Structures Containing Oocytes, 10.1634/stemcells.2005-0204
  46. Novak Ivana, Lightfoot Daniel A., Wang Hong, Eriksson Annika, Mahdy Ensaf, Höög Christer, Mouse Embryonic Stem Cells Form Follicle-Like Ovarian Structures but Do Not Progress Through Meiosis, 10.1634/stemcells.2005-0520
  47. Qing Tingting, Shi Yan, Qin Han, Ye Xin, Wei Wei, Liu Haisong, Ding Mingxiao, Deng Hongkui, Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells, 10.1111/j.1432-0436.2007.00181.x
  48. Chen H.-F., Kuo H.-C., Chien C.-L., Shun C.-T., Yao Y.-L., Ip P.-L., Chuang C.-Y., Wang C.-C., Yang Y.-S., Ho H-N., Derivation, characterization and differentiation of human embryonic stem cells: comparing serum-containing versus serum-free media and evidence of germ cell differentiation, 10.1093/humrep/del412
  49. Aflatoonian B., Ruban L., Jones M., Aflatoonian R., Fazeli A., Moore H.D., In vitro post-meiotic germ cell development from human embryonic stem cells, 10.1093/humrep/dep334
  50. Nicholas Cory R., Haston Kelly M., Grewall Amarjeet K., Longacre Teri A., Reijo Pera Renee A., Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility, 10.1093/hmg/ddp393
  51. SALVADOR L, SILVA C, KOSTETSKII I, RADICE G, STRAUSSIII J, The promoter of the oocyte-specific gene, Gdf9, is active in population of cultured mouse embryonic stem cells with an oocyte-like phenotype, 10.1016/j.ymeth.2008.03.004
  52. Hu Yue, Sun Junwei, Wang Jing, Wang Long, Bai Yaofu, Yu Meng, Lian Zhimin, Zhang Shanshan, Hua Jinlian, Characterization of female germ-like cells derived from mouse embryonic stem cells through expression of GFP under the control of Figla promoter, 10.1002/jcb.24044
  53. Wang Lu, Cao Jinping, Ji Ping, Zhang Di, Ma Lianghong, Dym Martin, Yu Zhuo, Feng Lixin, Oocyte-like cells induced from mouse spermatogonial stem cells, 10.1186/2045-3701-2-27
  54. Imamura Masanori, Aoi Takashi, Tokumasu Ako, Mise Nathan, Abe Kuniya, Yamanaka Shinya, Noce Toshiaki, Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes, 10.1002/mrd.21223
  55. Hayashi K., Ogushi S., Kurimoto K., Shimamoto S., Ohta H., Saitou M., Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice, 10.1126/science.1226889
  56. Niu Zhiwei, Hu Yue, Chu Zhili, Yu Meng, Bai Yaofu, Wang Long, Hua Jinlian, Germ-like cell differentiation from induced pluripotent stem cells (iPSCs) : GERM-LIKE CELLS DERIVED FROM IPSCS, 10.1002/cbf.2924
  57. Maherali Nimet, Ahfeldt Tim, Rigamonti Alessandra, Utikal Jochen, Cowan Chad, Hochedlinger Konrad, A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells, 10.1016/j.stem.2008.08.003
  58. Hochedlinger Konrad, Yamada Yasuhiro, Beard Caroline, Jaenisch Rudolf, Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues, 10.1016/j.cell.2005.02.018
  59. Foster K Wade, Liu Zhaoli, Nail Clinton D, Li Xingnan, Fitzgerald Thomas J, Bailey Sarah K, Frost Andra R, Louro Iuri D, Townes Tim M, Paterson Andrew J, Kudlow Jeffrey E, Lobo-Ruppert Susan M, Ruppert J Michael, Induction of KLF4 in basal keratinocytes blocks the proliferation–differentiation switch and initiates squamous epithelial dysplasia, 10.1038/sj.onc.1208307
  60. Grad, Eur Cell Mater, 22, 258 (2011)
  61. Carpenter Melissa K, Frey-Vasconcells Joyce, Rao Mahendra S, Developing safe therapies from human pluripotent stem cells, 10.1038/nbt0709-606
  62. Sommer Cesar A., Gianotti Sommer Andreia, Longmire Tyler A., Christodoulou Constantina, Thomas Dolly D., Gostissa Monica, Alt Fred W., Murphy George J., Kotton Darrell N., Mostoslavsky Gustavo, Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector, 10.1002/stem.255
  63. Woltjen Knut, Michael Iacovos P., Mohseni Paria, Desai Ridham, Mileikovsky Maria, Hämäläinen Riikka, Cowling Rebecca, Wang Wei, Liu Pentao, Gertsenstein Marina, Kaji Keisuke, Sung Hoon-Ki, Nagy Andras, piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells, 10.1038/nature07863
  64. Okita K., Nakagawa M., Hyenjong H., Ichisaka T., Yamanaka S., Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors, 10.1126/science.1164270
  65. Stadtfeld M., Nagaya M., Utikal J., Weir G., Hochedlinger K., Induced Pluripotent Stem Cells Generated Without Viral Integration, 10.1126/science.1162494
  66. FUSAKI Noemi, BAN Hiroshi, NISHIYAMA Akiyo, SAEKI Koichi, HASEGAWA Mamoru, Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome, 10.2183/pjab.85.348
  67. Warren Luigi, Manos Philip D., Ahfeldt Tim, Loh Yuin-Han, Li Hu, Lau Frank, Ebina Wataru, Mandal Pankaj K., Smith Zachary D., Meissner Alexander, Daley George Q., Brack Andrew S., Collins James J., Cowan Chad, Schlaeger Thorsten M., Rossi Derrick J., Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA, 10.1016/j.stem.2010.08.012
  68. Miyoshi Norikatsu, Ishii Hideshi, Nagano Hiroaki, Haraguchi Naotsugu, Dewi Dyah Laksmi, Kano Yoshihiro, Nishikawa Shinpei, Tanemura Masahiro, Mimori Koshi, Tanaka Fumiaki, Saito Toshiyuki, Nishimura Junichi, Takemasa Ichiro, Mizushima Tsunekazu, Ikeda Masataka, Yamamoto Hirofumi, Sekimoto Mitsugu, Doki Yuichiro, Mori Masaki, Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs, 10.1016/j.stem.2011.05.001
  69. Kaji Keisuke, Norrby Katherine, Paca Agnieszka, Mileikovsky Maria, Mohseni Paria, Woltjen Knut, Virus-free induction of pluripotency and subsequent excision of reprogramming factors, 10.1038/nature07864
  70. Sekiya Sayaka, Suzuki Atsushi, Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors, 10.1038/nature10263
  71. Caiazzo Massimiliano, Dell’Anno Maria Teresa, Dvoretskova Elena, Lazarevic Dejan, Taverna Stefano, Leo Damiana, Sotnikova Tatyana D., Menegon Andrea, Roncaglia Paola, Colciago Giorgia, Russo Giovanni, Carninci Piero, Pezzoli Gianni, Gainetdinov Raul R., Gustincich Stefano, Dityatev Alexander, Broccoli Vania, Direct generation of functional dopaminergic neurons from mouse and human fibroblasts, 10.1038/nature10284
  72. Inagawa K., Miyamoto K., Yamakawa H., Muraoka N., Sadahiro T., Umei T., Wada R., Katsumata Y., Kaneda R., Nakade K., Kurihara C., Obata Y., Miyake K., Fukuda K., Ieda M., Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5, 10.1161/circresaha.112.271148
  73. Zhou Heping, Jin Zhenxiao, Liu Jincheng, Yu Shiqiang, Cui Qin, Yi Dinghua, Mesenchymal stem cells might be used to induce tolerance in heart transplantation, 10.1016/j.mehy.2007.08.010
  74. Song Kunhua, Nam Young-Jae, Luo Xiang, Qi Xiaoxia, Tan Wei, Huang Guo N., Acharya Asha, Smith Christopher L., Tallquist Michelle D., Neilson Eric G., Hill Joseph A., Bassel-Duby Rhonda, Olson Eric N., Heart repair by reprogramming non-myocytes with cardiac transcription factors, 10.1038/nature11139
  75. Rodríguez-Pizà Ignasi, Richaud-Patin Yvonne, Vassena Rita, González Federico, Barrero María José, Veiga Anna, Raya Angel, Izpisúa Belmonte Juan Carlos, Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells Under Xeno-Free Conditions, 10.1002/stem.248
  76. Sun N., Panetta N. J., Gupta D. M., Wilson K. D., Lee A., Jia F., Hu S., Cherry A. M., Robbins R. C., Longaker M. T., Wu J. C., Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells, 10.1073/pnas.0908450106
  77. Soldner Frank, Hockemeyer Dirk, Beard Caroline, Gao Qing, Bell George W., Cook Elizabeth G., Hargus Gunnar, Blak Alexandra, Cooper Oliver, Mitalipova Maisam, Isacson Ole, Jaenisch Rudolf, Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors, 10.1016/j.cell.2009.02.013
  78. Panicker L. M., Miller D., Park T. S., Patel B., Azevedo J. L., Awad O., Masood M. A., Veenstra T. D., Goldin E., Stubblefield B. K., Tayebi N., Polumuri S. K., Vogel S. N., Sidransky E., Zambidis E. T., Feldman R. A., Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease, 10.1073/pnas.1207889109
  79. Maehr R., Chen S., Snitow M., Ludwig T., Yagasaki L., Goland R., Leibel R. L., Melton D. A., Generation of pluripotent stem cells from patients with type 1 diabetes, 10.1073/pnas.0906894106
  80. Somers Aba, Jean Jyh-Chang, Sommer Cesar A., Omari Amel, Ford Christopher C., Mills Jason A., Ying Lei, Sommer Andreia Gianotti, Jean Jenny M., Smith Brenden W., Lafyatis Robert, Demierre Marie-France, Weiss Daniel J., French Deborah L., Gadue Paul, Murphy George J., Mostoslavsky Gustavo, Kotton Darrell N., Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette, 10.1002/stem.495
  81. Rashid S. Tamir, Corbineau Sebastien, Hannan Nick, Marciniak Stefan J., Miranda Elena, Alexander Graeme, Huang-Doran Isabel, Griffin Julian, Ahrlund-Richter Lars, Skepper Jeremy, Semple Robert, Weber Anne, Lomas David A., Vallier Ludovic, Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells, 10.1172/jci43122
  82. Ghodsizadeh Arefeh, Taei Adeleh, Totonchi Mehdi, Seifinejad Ali, Gourabi Hamid, Pournasr Behshad, Aghdami Nasser, Malekzadeh Reza, Almadani Navid, Salekdeh Ghasem Hosseini, Baharvand Hossein, Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells, 10.1007/s12015-010-9189-3
  83. Tolar Jakub, Xia Lily, Riddle Megan J., Lees Chris J., Eide Cindy R., McElmurry Ron T., Titeux Matthias, Osborn Mark J., Lund Troy C., Hovnanian Alain, Wagner John E., Blazar Bruce R., Induced Pluripotent Stem Cells from Individuals with Recessive Dystrophic Epidermolysis Bullosa, 10.1038/jid.2010.346
  84. Lemonnier Thomas, Blanchard Stéphane, Toli Diana, Roy Elise, Bigou Stéphanie, Froissart Roseline, Rouvet Isabelle, Vitry Sandrine, Heard Jean Michel, Bohl Delphine, Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells, 10.1093/hmg/ddr285
  85. Trilck Michaela, Hübner Rayk, Seibler Philip, Klein Christine, Rolfs Arndt, Frech Moritz J, Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks, 10.1186/1750-1172-8-144
  86. Schneider B. L., Seehus C. R., Capowski E. E., Aebischer P., Zhang S.-C., Svendsen C. N., Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation, 10.1093/hmg/ddm008
  87. Hargus G., Cooper O., Deleidi M., Levy A., Lee K., Marlow E., Yow A., Soldner F., Hockemeyer D., Hallett P. J., Osborn T., Jaenisch R., Isacson O., Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats, 10.1073/pnas.1010209107
  88. Swistowski Andrzej, Peng Jun, Liu Qiuyue, Mali Prashant, Rao Mahendra S., Cheng Linzhao, Zeng Xianmin, Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions, 10.1002/stem.499
  89. Seibler P., Graziotto J., Jeong H., Simunovic F., Klein C., Krainc D., Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells, 10.1523/jneurosci.4441-10.2011
  90. Devine Michael J., Ryten Mina, Vodicka Petr, Thomson Alison J., Burdon Tom, Houlden Henry, Cavaleri Fatima, Nagano Masumi, Drummond Nicola J., Taanman Jan-Willem, Schapira Anthony H., Gwinn Katrina, Hardy John, Lewis Patrick A., Kunath Tilo, Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus, 10.1038/ncomms1453
  91. Nguyen Ha Nam, Byers Blake, Cord Branden, Shcheglovitov Aleksandr, Byrne James, Gujar Prachi, Kee Kehkooi, Schüle Birgitt, Dolmetsch Ricardo E., Langston William, Palmer Theo D., Pera Renee Reijo, LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress, 10.1016/j.stem.2011.01.013
  92. Park In-Hyun, Arora Natasha, Huo Hongguang, Maherali Nimet, Ahfeldt Tim, Shimamura Akiko, Lensch M. William, Cowan Chad, Hochedlinger Konrad, Daley George Q., Disease-Specific Induced Pluripotent Stem Cells, 10.1016/j.cell.2008.07.041
  93. Zhang Ningzhe, An Mahru C., Montoro Daniel, Ellerby Lisa M., Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells, 10.1371/currents.rrn1193
  94. Dimos J. T., Rodolfa K. T., Niakan K. K., Weisenthal L. M., Mitsumoto H., Chung W., Croft G. F., Saphier G., Leibel R., Goland R., Wichterle H., Henderson C. E., Eggan K., Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons, 10.1126/science.1158799
  95. Mitne-Neto Miguel, Machado-Costa Marcela, Marchetto Maria C.N., Bengtson Mario H., Joazeiro Claudio A., Tsuda Hiroshi, Bellen Hugo J., Silva Helga C.A., Oliveira Acary S.B., Lazar Monize, Muotri Alysson R., Zatz Mayana, Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients, 10.1093/hmg/ddr284
  96. Marchetto Maria C.N., Carromeu Cassiano, Acab Allan, Yu Diana, Yeo Gene W., Mu Yangling, Chen Gong, Gage Fred H., Muotri Alysson R., A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells, 10.1016/j.cell.2010.10.016
  97. Cheung Aaron Y.L., Horvath Lindsay M., Grafodatskaya Daria, Pasceri Peter, Weksberg Rosanna, Hotta Akitsu, Carrel Laura, Ellis James, Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation, 10.1093/hmg/ddr093
  98. Kim K.-Y., Hysolli E., Park I.-H., Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome, 10.1073/pnas.1018979108
  99. Ebert Allison D., Yu Junying, Rose Ferrill F., Mattis Virginia B., Lorson Christian L., Thomson James A., Svendsen Clive N., Induced pluripotent stem cells from a spinal muscular atrophy patient, 10.1038/nature07677
  100. Chang Tammy, Zheng Weiyan, Tsark Walter, Bates Steven, Huang He, Lin Ren-Jang, Yee Jiing-Kuan, Brief Report: Phenotypic Rescue of Induced Pluripotent Stem Cell-Derived Motoneurons of a Spinal Muscular Atrophy Patient, 10.1002/stem.749
  101. Chamberlain Stormy J., Chen Pin-Fang, Ng Khong Y., Bourgois-Rocha Fany, Lemtiri-Chlieh Fouad, Levine Eric S., Lalande Marc, Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes, 10.1073/pnas.1004487107
  102. Yang Jiayin, Cai Jie, Zhang Ya, Wang Xianming, Li Wen, Xu Jianyong, Li Feng, Guo Xiangpeng, Deng Kang, Zhong Mei, Chen Yonglong, Lai Liangxue, Pei Duanqing, Esteban Miguel A., Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome, 10.1074/jbc.m110.183392
  103. Liu Jun, Verma Paul J., Evans-Galea Marguerite V., Delatycki Martin B., Michalska Anna, Leung Jessie, Crombie Duncan, Sarsero Joseph P., Williamson Robert, Dottori Mirella, Pébay Alice, Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients, 10.1007/s12015-010-9210-x
  104. Brennand Kristen J., Simone Anthony, Jou Jessica, Gelboin-Burkhart Chelsea, Tran Ngoc, Sangar Sarah, Li Yan, Mu Yangling, Chen Gong, Yu Diana, McCarthy Shane, Sebat Jonathan, Gage Fred H., Modelling schizophrenia using human induced pluripotent stem cells, 10.1038/nature09915
  105. Koch Philipp, Breuer Peter, Peitz Michael, Jungverdorben Johannes, Kesavan Jaideep, Poppe Daniel, Doerr Jonas, Ladewig Julia, Mertens Jerome, Tüting Thomas, Hoffmann Per, Klockgether Thomas, Evert Bernd O., Wüllner Ullrich, Brüstle Oliver, Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease, 10.1038/nature10671
  106. Jang Jiho, Kang Hoon-Chul, Kim Han-Soo, Kim Ji Young, Huh Yong Jun, Kim Dae-Sung, Yoo Jeong-Eun, Lee Jeong-Ah, Lim Boyoung, Lee Jiwon, Yoon Tae-Min, Park In-Hyun, Hwang Dong-Youn, Daley George Q., Kim Dong-Wook, Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients, 10.1002/ana.22486
  107. Yagi Takuya, Ito Daisuke, Okada Yohei, Akamatsu Wado, Nihei Yoshihiro, Yoshizaki Takahito, Yamanaka Shinya, Okano Hideyuki, Suzuki Norihiro, Modeling familial Alzheimer's disease with induced pluripotent stem cells, 10.1093/hmg/ddr394
  108. Israel Mason A., Yuan Shauna H., Bardy Cedric, Reyna Sol M., Mu Yangling, Herrera Cheryl, Hefferan Michael P., Van Gorp Sebastiaan, Nazor Kristopher L., Boscolo Francesca S., Carson Christian T., Laurent Louise C., Marsala Martin, Gage Fred H., Remes Anne M., Koo Edward H., Goldstein Lawrence S. B., Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells, 10.1038/nature10821
  109. Meyer Jason S., Howden Sara E., Wallace Kyle A., Verhoeven Amelia D., Wright Lynda S., Capowski Elizabeth E., Pinilla Isabel, Martin Jessica M., Tian Shulan, Stewart Ron, Pattnaik Bikash, Thomson James A., Gamm David M., Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment, 10.1002/stem.674
  110. Tucker B. A., Scheetz T. E., Mullins R. F., DeLuca A. P., Hoffmann J. M., Johnston R. M., Jacobson S. G., Sheffield V. C., Stone E. M., Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa, 10.1073/pnas.1108918108
  111. Jin Zi-Bing, Okamoto Satoshi, Xiang Ping, Takahashi Masayo, Integration-Free Induced Pluripotent Stem Cells Derived from Retinitis Pigmentosa Patient for Disease Modeling, 10.5966/sctm.2012-0005
  112. Zahabi Azadeh, Shahbazi Ebrahim, Ahmadieh Hamid, Hassani Seyedeh-Nafiseh, Totonchi Mehdi, Taei Adeleh, Masoudi Najmehsadat, Ebrahimi Marzieh, Aghdami Nasser, Seifinejad Ali, Mehrnejad Faramarz, Daftarian Narsis, Salekdeh Ghasem Hosseini, Baharvand Hossein, A New Efficient Protocol for Directed Differentiation of Retinal Pigmented Epithelial Cells from Normal and Retinal Disease Induced Pluripotent Stem Cells, 10.1089/scd.2011.0599
  113. Raya Ángel, Rodríguez-Pizà Ignasi, Guenechea Guillermo, Vassena Rita, Navarro Susana, Barrero María José, Consiglio Antonella, Castellà Maria, Río Paula, Sleep Eduard, González Federico, Tiscornia Gustavo, Garreta Elena, Aasen Trond, Veiga Anna, Verma Inder M., Surrallés Jordi, Bueren Juan, Belmonte Juan Carlos Izpisúa, Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells, 10.1038/nature08129
  114. Ye L., Chang J. C., Lin C., Sun X., Yu J., Kan Y. W., Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases, 10.1073/pnas.0904689106
  115. Hu K., Yu J., Suknuntha K., Tian S., Montgomery K., Choi K.-D., Stewart R., Thomson J. A., Slukvin I. I., Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells, 10.1182/blood-2010-07-298331
  116. Bedel Aurélie, Pasquet Jean- Max, Lippert Éric, Taillepierre Miguel, Lagarde Valérie, Dabernat Sandrine, Dubus Pierre, Charaf Lucie, Beliveau François, de Verneuil Hubert, Richard Emmanuel, Mahon François-Xavier, Moreau-Gaudry François, Variable Behavior of iPSCs Derived from CML Patients for Response to TKI and Hematopoietic Differentiation, 10.1371/journal.pone.0071596
  117. Morishima T., Watanabe K.-i., Niwa A., Hirai H., Saida S., Tanaka T., Kato I., Umeda K., Hiramatsu H., Saito M. K., Matsubara K., Adachi S., Kobayashi M., Nakahata T., Heike T., Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis, 10.3324/haematol.2013.083873
  118. Carvajal-Vergara Xonia, Sevilla Ana, D’Souza Sunita L., Ang Yen-Sin, Schaniel Christoph, Lee Dung-Fang, Yang Lei, Kaplan Aaron D., Adler Eric D., Rozov Roye, Ge YongChao, Cohen Ninette, Edelmann Lisa J., Chang Betty, Waghray Avinash, Su Jie, Pardo Sherly, Lichtenbelt Klaske D., Tartaglia Marco, Gelb Bruce D., Lemischka Ihor R., Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome, 10.1038/nature09005
  119. Moretti Alessandra, Bellin Milena, Welling Andrea, Jung Christian Billy, Lam Jason T., Bott-Flügel Lorenz, Dorn Tatjana, Goedel Alexander, Höhnke Christian, Hofmann Franz, Seyfarth Melchior, Sinnecker Daniel, Schömig Albert, Laugwitz Karl-Ludwig, Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome, 10.1056/nejmoa0908679
  120. Yazawa Masayuki, Hsueh Brian, Jia Xiaolin, Pasca Anca M., Bernstein Jonathan A., Hallmayer Joachim, Dolmetsch Ricardo E., Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome, 10.1038/nature09855
  121. Davis R. P., Casini S., van den Berg C. W., Hoekstra M., Remme C. A., Dambrot C., Salvatori D., Oostwaard D. W.-v., Wilde A. A. M., Bezzina C. R., Verkerk A. O., Freund C., Mummery C. L., Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease, 10.1161/circulationaha.111.066092
  122. Sun N., Yazawa M., Liu J., Han L., Sanchez-Freire V., Abilez O. J., Navarrete E. G., Hu S., Wang L., Lee A., Pavlovic A., Lin S., Chen R., Hajjar R. J., Snyder M. P., Dolmetsch R. E., Butte M. J., Ashley E. A., Longaker M. T., Robbins R. C., Wu J. C., Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy, 10.1126/scitranslmed.3003552
  123. Itzhaki Ilanit, Maizels Leonid, Huber Irit, Zwi-Dantsis Limor, Caspi Oren, Winterstern Aaron, Feldman Oren, Gepstein Amira, Arbel Gil, Hammerman Haim, Boulos Monther, Gepstein Lior, Modelling the long QT syndrome with induced pluripotent stem cells, 10.1038/nature09747
  124. Matsa Elena, Rajamohan Divya, Dick Emily, Young Lorraine, Mellor Ian, Staniforth Andrew, Denning Chris, Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation, 10.1093/eurheartj/ehr073
  125. Lahti A. L., Kujala V. J., Chapman H., Koivisto A.-P., Pekkanen-Mattila M., Kerkela E., Hyttinen J., Kontula K., Swan H., Conklin B. R., Yamanaka S., Silvennoinen O., Aalto-Setala K., Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture, 10.1242/dmm.008409
  126. Fatima Azra, Xu Guoxing, Shao Kaifeng, Papadopoulos Symeon, Lehmann Martin, Arnáiz-Cot Juan J., Rosa Angelo O., Nguemo Filomain, Matzkies Matthias, Dittmann Sven, Stone Susannah L., Linke Matthias, Zechner Ulrich, Beyer Vera, Hennies Hans Christian, Rosenkranz Stephan, Klauke Baerbel, Parwani Abdul S., Haverkamp Wilhelm, Pfitzer Gabriele, Farr Martin, Cleemann Lars, Morad Martin, Milting Hendrik, Hescheler Juergen, Šaric Tomo, In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells, 10.1159/000335753
  127. Jung Christian B., Moretti Alessandra, Mederos y Schnitzler Michael, Iop Laura, Storch Ursula, Bellin Milena, Dorn Tatjana, Ruppenthal Sandra, Pfeiffer Sarah, Goedel Alexander, Dirschinger Ralf J., Seyfarth Melchior, Lam Jason T., Sinnecker Daniel, Gudermann Thomas, Lipp Peter, Laugwitz Karl-Ludwig, Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia : Patient-specific stem cell model of CPVT1, 10.1002/emmm.201100194
  128. Kujala Kirsi, Paavola Jere, Lahti Anna, Larsson Kim, Pekkanen-Mattila Mari, Viitasalo Matti, Lahtinen Annukka M., Toivonen Lauri, Kontula Kimmo, Swan Heikki, Laine Mika, Silvennoinen Olli, Aalto-Setälä Katriina, Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations, 10.1371/journal.pone.0044660
  129. Di Pasquale E, Lodola F, Miragoli M, Denegri M, Avelino-Cruz J E, Buonocore M, Nakahama H, Portararo P, Bloise R, Napolitano C, Condorelli G, Priori S G, CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia, 10.1038/cddis.2013.369
  130. Kim Changsung, Wong Johnson, Wen Jianyan, Wang Shirong, Wang Cheng, Spiering Sean, Kan Natalia G., Forcales Sonia, Puri Pier Lorenzo, Leone Teresa C., Marine Joseph E., Calkins Hugh, Kelly Daniel P., Judge Daniel P., Chen Huei-Sheng Vincent, Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs, 10.1038/nature11799
  131. Weick J. P., Held D. L., Bonadurer G. F., Doers M. E., Liu Y., Maguire C., Clark A., Knackert J. A., Molinarolo K., Musser M., Yao L., Yin Y., Lu J., Zhang X., Zhang S.-C., Bhattacharyya A., Deficits in human trisomy 21 iPSCs and neurons, 10.1073/pnas.1216575110
  132. Li Yao, Tsai Yi-Ting, , 10.2119/molmed.2012.00242
  133. Ma Dongrui, Wei Heming, Lu Jun, Ho Shuswen, Zhang Guangqing, Sun Xiaoming, Oh Yingzi, Tan Suat Hoon, Ng Mah Lee, Shim Winston, Wong Philip, Liew Reginald, Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy, 10.1093/eurheartj/ehs226
  134. Ye Z., Zhan H., Mali P., Dowey S., Williams D. M., Jang Y.-Y., Dang C. V., Spivak J. L., Moliterno A. R., Cheng L., Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders, 10.1182/blood-2009-04-217406
Bibliographic reference Wyns, Christine ; Botman, Olivier. Induced pluripotent stem cell potential in medicine, specifically focused on reproductive medicine. In: Frontiers in surgery, Vol. 1, no. 5, p. 1-10 (2014)
Permanent URL http://hdl.handle.net/2078.1/140771