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Assessment of left ventricular diastolic function in patients receiving anthracycline therapy.

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Parmentier, S. Melin, Jacques [UCL] Piret, L. Beckers, Christian [UCL]

Abnormalities in left ventricular filling have been described as an early finding in coronary artery disease and in cardiomyopathy. The present study was undertaken to determine whether impaired diastolic function may be an early sign of anthracycline cardiotoxicity. Radionuclide left ventricular curves of 30 treated patients were compared with the curves of 17 normal, agematched, volunteers. The curves were analyzed for ejection fraction, peak filling rate (normalized for end diastolic counts and for stroke counts), time to peak filling rate and filling fraction in the first third of diastole normalized for cycle length. In 20 patients (Groups A and B), we analyzed the radionuclide ventriculography preceding the decrease of systolic function or a clinical congestive heart failure. In ten patients (Group C) who ended a treatment regimen without systolic dysfunction or clinically evident cardiotoxicity, we analyzed the ventriculography at the end of the therapy. Among the diastolic indexes, only the first third filling fraction was abnormal in a minority of the patients (6/20 in Groups A and B). Our findings suggest that diastolic dysfunction is uncommon in anthracycline treated patients prior to systolic dysfunction.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1988
Journal information "European journal of nuclear medicine" - Vol. 13, no. 11, p. 563-7 (1988)
issn 0340-6997
Publication status Publié
Affiliation UCL
MESH Subject Adult ; Aged ; Antibiotics, Antineoplastic - adverse effects - therapeutic use ; Diastole ; Female ; Heart - physiopathology - radionuclide imaging ; Heart Failure - drug therapy - physiopathology - radionuclide imaging ; Heart Ventricles - physiopathology - radionuclide imaging ; Humans ; Male ; Middle Aged ; Myocardial Contraction ; Naphthacenes - adverse effects - therapeutic use ; Stroke Volume
Links
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Bibliographic reference Parmentier, S. ; Melin, Jacques ; Piret, L. ; Beckers, Christian. Assessment of left ventricular diastolic function in patients receiving anthracycline therapy.. In: European journal of nuclear medicine, Vol. 13, no. 11, p. 563-7 (1988)
Permanent URL http://hdl.handle.net/2078.1/14025