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Role of oxidative stress in the pathogenesis of alcohol-induced liver disease

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Sid, Brice [UCL] Verrax, Julien [UCL] Buc Calderon, Pedro [UCL]

Abstract Chronic alcohol consumption is a well-known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The pathological process of alcohol-induced liver disease is characterized by a broad spectrum of morphological changes ranging from steatosis with minimal injury to more advanced liver damage, including steato-hepatitis and fibrosis/cirrhosis. Experimental and clinical studies increasingly show that the oxidative damage induced by ethanol contribute in many ways to the pathogenesis of alcohol hepatotoxicity. This article describes the contribution of oxidative mechanisms to liver damage by alcohol

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2013
Language Anglais
Journal information "Free Radical Research" - Vol. 47, no.11, p. 894-904 (2013)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 1071-5762
e-issn 1029-2470
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords alcohol ; liver disease ; oxidative damage ; reactive oxygen species
Links
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Bibliographic reference Sid, Brice ; Verrax, Julien ; Buc Calderon, Pedro. Role of oxidative stress in the pathogenesis of alcohol-induced liver disease. In: Free Radical Research, Vol. 47, no.11, p. 894-904 (2013)
Permanent URL http://hdl.handle.net/2078.1/134911