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Haematological disturbances during long-term valproate therapy.

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Brichard, Bénédicte [UCL] Vermylen, Christiane [UCL] Scheiff, Jean-Marie [UCL] Ninane, Jacques [UCL] Cornu, Guy [UCL]

A 14-year-old boy with mental retardation presented with severe thrombocytopenia, macrocytic anaemia and allergic dermatitis. He had been treated with valproate for seizures since the age of 2 years. Clinical examination showed severe purpura, mucous bleeding and extensive dermatitis. Tests to detect serum direct antiplatelet antibodies were positive and bone marrow examination revealed myelodysplastic abnormalities. Valproate was discontinued and both dermatitis and general condition of the child improved with normalization of the full blood count. This report suggests that valproate may produce both peripheral immune thrombocytopenia and severe bone marrow depression several years after the initiation of the therapy.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "European Journal of Pediatrics" - Vol. 153, no. 5, p. 378-380 (1994)
Peer reviewed yes
Publisher Springer (Heidelberg)
issn 0340-6199
e-issn 1432-1076
Publication status Publié
Affiliations UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
UCL - MD/MNOP - Département de morphologie normale et pathologique
UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique
UCL - (SLuc) Service de biologie hématologique
UCL - (SLuc) Service d'hématologie
MESH Subject Adolescent ; Anemia, Macrocytic - chemically induced ; Dermatitis, Atopic - chemically induced ; Humans ; Male ; Seizures - drug therapy ; Thrombocytopenia - chemically induced ; Valproic Acid - adverse effects
Keywords Valproate ; Macrocytic anaemia ; Thrombocytopenia myelodysplastic syndrome ; Atopic dermatitis
Links
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Bibliographic reference Brichard, Bénédicte ; Vermylen, Christiane ; Scheiff, Jean-Marie ; Ninane, Jacques ; Cornu, Guy. Haematological disturbances during long-term valproate therapy.. In: European Journal of Pediatrics, Vol. 153, no. 5, p. 378-380 (1994)
Permanent URL http://hdl.handle.net/2078.1/13456