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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer

Bibliographic reference Kennedy, Kelly M ; Scarbrough, Peter M ; Ribeiro, Anthony ; Richardson, Rachel ; Yuan, Hong ; et. al. Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. In: PLoS One, Vol. 8, no. 9, p. e75154 (2013)
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  1. Duh S-H, Cook JD (2005) LABORATORY REFERENCE RANGE VALUES. MDUSA: University of Maryland School of Medicine. APP17 APP17. 17 p.
  2. S Walenta, Cancer Res, 60, 916 (2000)
  3. Warburg O (1930) The metabolism of tumors. Arnold Constable London, UK.
  4. Warburg OH, Dickens F, Kaiser-Wilhelm-Institut fuÎr Biologie. (1930) The Metabolism of tumours : investigations from the Kaiser Wilhelm Institute for Biology, Berlin-Dahlem. London: Constable. xxviii, 327 p., 325 leaves of plates p.
  5. Warburg OH, Kaiser-Wilhelm-Institut fuÎr Biologie. (1926) Ãœber den Stoffwechsel der Tumoren : Arbeiten aus dem Kaiser Wilheim-Institut für Biologie, Berlin-Dahlem. Berlin: Julius Springer.263 p. p.
  6. Hanahan Douglas, Weinberg Robert A., Hallmarks of Cancer: The Next Generation, 10.1016/j.cell.2011.02.013
  7. Gatenby Robert A., Gillies Robert J., Why do cancers have high aerobic glycolysis?, 10.1038/nrc1478
  8. Gatenby R A, Smallbone K, Maini P K, Rose F, Averill J, Nagle R B, Worrall L, Gillies R J, Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer, 10.1038/sj.bjc.6603922
  9. Dang Chi V, Semenza Gregg L, Oncogenic alterations of metabolism, 10.1016/s0968-0004(98)01344-9
  10. Schroeder Thies, Yuan Hong, Viglianti Benjamin L., Peltz Cathryn, Asopa Shubha, Vujaskovic Zeljko, Dewhirst Mark W., Spatial Heterogeneity and Oxygen Dependence of Glucose Consumption in R3230Ac and Fibrosarcomas of the Fischer 344 Rat, 10.1158/0008-5472.can-04-3900
  11. DM Brizel, Cancer Res, 56, 941 (1996)
  12. Brizel David M., Sibley Gregory S., Prosnitz Leonard R., Scher Richard L., Dewhirst Mark W., Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck, 10.1016/s0360-3016(97)00101-6
  13. Chen Julia Ling-Yu, Lucas Joseph E., Schroeder Thies, Mori Seiichi, Wu Jianli, Nevins Joseph, Dewhirst Mark, West Mike, Chi Jen-Tsan, The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers, 10.1371/journal.pgen.1000293
  14. Halestrap Andrew P., Meredith David, The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond, 10.1007/s00424-003-1067-2
  15. HALESTRAP Andrew P., PRICE Nigel T., The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation, 10.1042/bj3430281
  16. Kennedy Kelly M, Dewhirst Mark W, Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation, 10.2217/fon.09.145
  17. P Sonveaux, J Clin Invest, 118, 3930 (2008)
  18. Hussien R., Brooks G. A., Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines, 10.1152/physiolgenomics.00177.2010
  19. JE Manning Fox, J Physiol, 529 Pt 2, 285 (2000)
  20. Fang J., Quinones Q. J., Holman T. L., Morowitz M. J., Wang Q., Zhao H., Sivo F., Maris J. M., Wahl M. L., The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma, 10.1124/mol.106.026245
  21. Peltz Cathryn, Schroeder Thies, Dewhirst Mark W., Monitoring Metabolite Gradients in the Blood, Liver, and Tumor after Induced Hyperglycemia in Rats with R3230 Flank Tumors Using Microdialysis and Bioluminescence Imaging, Oxygen Transport to Tissue XXVI ISBN:038725062X p.343-348, 10.1007/0-387-26206-7_45
  22. Walenta Stefan, Snyder Stacey, Haroon Zishan A, Braun Rod D, Amin Khalid, Brizel David, Mueller-Klieser Wolfgang, Chance Britton, Dewhirst Mark W, Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model, 10.1016/s0360-3016(01)01700-x
  23. Neve Richard M., Chin Koei, Fridlyand Jane, Yeh Jennifer, Baehner Frederick L., Fevr Tea, Clark Laura, Bayani Nora, Coppe Jean-Philippe, Tong Frances, Speed Terry, Spellman Paul T., DeVries Sandy, Lapuk Anna, Wang Nick J., Kuo Wen-Lin, Stilwell Jackie L., Pinkel Daniel, Albertson Donna G., Waldman Frederic M., McCormick Frank, Dickson Robert B., Johnson Michael D., Lippman Marc, Ethier Stephen, Gazdar Adi, Gray Joe W., A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, 10.1016/j.ccr.2006.10.008
  24. Ibrahim Ezzeldin, Al-Gahmi Aboelkhair M., Zeenelin Ahmed A., Zekri Jamal M., Elkhodary Tawfik R., Gaballa Hussein E., Fawzy Ehab E., El sayed Mohamed E., Alzahrani Mohamed S., Basal vs. luminal a breast cancer subtypes: a matched case-control study using estrogen receptor, progesterone receptor, and HER-2 as surrogate markers, 10.1007/s12032-008-9131-6
  25. Rouzier R., Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy, 10.1158/1078-0432.ccr-04-2421
  26. Asada Kiyoshi, Miyamoto Kazuaki, Fukutomi Takashi, Tsuda Hitoshi, Yagi Yukiko, Wakazono Kuniko, Oishi Shoko, Fukui Hiroshi, Sugimura Takashi, Ushijima Toshikazu, Reduced Expression of GNA11 and Silencing of MCT1 in Human Breast Cancers, 10.1159/000070297
  27. EA Komarova, Cancer Res, 57, 5217 (1997)
  28. OS Filyak, Ukr Biokhim Zh, 77, 136 (2005)
  29. JA Kellen, In Vivo, 10, 511 (1996)
  30. L Hui, 25, 7305 (2006)
  31. D Katayose, Clin Cancer Res, 1, 889 (1995)
  32. Maddocks Oliver D. K., Vousden Karen H., Metabolic regulation by p53, 10.1007/s00109-011-0735-5
  33. Boidot R., Vegran F., Meulle A., Le Breton A., Dessy C., Sonveaux P., Lizard-Nacol S., Feron O., Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors, 10.1158/0008-5472.can-11-2474
  34. Brizel David M, Schroeder Thies, Scher Richard L, Walenta Stefan, Clough Robert W, Dewhirst Mark W, Mueller-Klieser Wolfgang, Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer, 10.1016/s0360-3016(01)01630-3
  35. Walenta Stefan, Chau The-Van, Schroeder Thies, Lehr Hans-Anton, Kunz-Schughart Leoni A., Fuerst Alois, Mueller-Klieser Wolfgang, Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?, 10.1007/s00432-003-0450-x
  36. Mueller-Klieser W., Walenta S., Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging, 10.1007/bf00157805
  37. Schwickert G., Walenta S., Mueller-Klieser W., Mapping and quantification of biomolecules in tumor biopsies using bioluminescence, 10.1007/bf01919316
  38. S Walenta, Am J Pathol, 150, 409 (1997)
  39. Walenta S., Schroeder T., Mueller-Klieser W., Lactate in Solid Malignant Tumors: Potential Basis of a Metabolic Classification in Clinical Oncology, 10.2174/0929867043364711
  40. Yokota Hajime, Guo Jianfei, Matoba Munetaka, Higashi Kotaro, Tonami Hisao, Nagao Yosinobu, Lactate, choline, and creatine levels measured by vitro1H-MRS as prognostic parameters in patients with non-small-cell lung cancer, 10.1002/jmri.20902
  41. Kumar V, Abbas AK, Fausto N (2005) Robbins and Cotran Pathological Basis of Disease. Philadelphia, PA: Elsevier Saunders.
  42. Blackburn RobertV, Spitz DouglasR, Liu Xin, Galoforo SandraS, Sim JuliaE, Ridnour LisaA, Chen JennC, Davis BruceH, Corry PeterM, Lee YongJ, Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells, 10.1016/s0891-5849(98)00217-2
  43. Ahmad Iman M., Aykin-Burns Nukhet, Sim Julia E., Walsh Susan A., Higashikubo Ryuji, Buettner Garry R., Venkataraman Sujatha, Mackey Michael A., Flanagan Shawn W., Oberley Larry W., Spitz Douglas R., Mitochondrial and H2O2Mediate Glucose Deprivation-induced Stress in Human Cancer Cells, 10.1074/jbc.m411662200
  44. Spitz DouglasR, Simons AndreanL, Mattson DavidM, Dornfeld Ken, Glucose deprivation-induced metabolic oxidative stress and cancer therapy, 10.4103/0973-1482.55133
  45. SPITZ DOUGLAS R., SIM JULIA E., RIDNOUR LISA A., GALOFORO SANDRA S., LEE YONG J., Glucose Deprivation-Induced Oxidative Stress in Human Tumor Cells: A Fundamental Defect in Metabolism?, 10.1111/j.1749-6632.2000.tb06199.x
  46. G Schwickert, Cancer Res, 55, 4757 (1995)
  47. Walenta Stefan, Mueller-Klieser Wolfgang F, Lactate: mirror and motor of tumor malignancy, 10.1016/j.semradonc.2004.04.004
  48. Pinheiro Céline, Albergaria André, Paredes Joana, Sousa Bárbara, Dufloth Rozany, Vieira Daniella, Schmitt Fernando, Baltazar Fátima, Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma : MCT1 in breast cancer, 10.1111/j.1365-2559.2010.03560.x
  49. Pinheiro Céline, Longatto-Filho Adhemar, Ferreira Luísa, Pereira Sônia Maria Miranda, Etlinger Daniela, Moreira Marise A. R., Jubé Luiz Fernando, Queiroz Geraldo Silva, Schmitt Fernando, Baltazar Fátima, Increasing Expression of Monocarboxylate Transporters 1 and 4 Along Progression to Invasive Cervical Carcinoma : , 10.1097/pgp.0b013e31817b5b40
  50. Pinheiro Céline, Longatto-Filho Adhemar, Scapulatempo Cristovam, Ferreira Luísa, Martins Sandra, Pellerin Luc, Rodrigues Mesquita, Alves Venancio A. F., Schmitt Fernando, Baltazar Fátima, Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas, 10.1007/s00428-007-0558-5
  51. J Biomed Biotechnol, 2010, 427694
  52. DIMMER Kai-Stefan, FRIEDRICH Björn, LANG Florian, DEITMER Joachim W., BRÖER Stefan, The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells, 10.1042/bj3500219
  53. A Bonen, Am J Physiol Endocrinol Metab, 278, E1067 (2000)
  54. Ullah Mohammed S., Davies Andrew J., Halestrap Andrew P., The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism, 10.1074/jbc.m511397200
  55. R Hilf, Cancer Res, 46, 211 (1986)
  56. Sauer Leonard A., Dauchy Robert T., Lactate release and uptake in hepatoma 7288CTC perfused in situ with l-[(U)-14C] lactate or d-[(U)-14C] glucose, 10.1016/0026-0495(94)90006-x
  57. LA Sauer, Cancer Res, 46, 689 (1986)
  58. Guillaumond F., Leca J., Olivares O., Lavaut M.-N., Vidal N., Berthezene P., Dusetti N. J., Loncle C., Calvo E., Turrini O., Iovanna J. L., Tomasini R., Vasseur S., Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma, 10.1073/pnas.1219555110
  59. Bouzier A.-K., Voisin P., Goodwin R., Canioni P., Merle M., Glucose and Lactate Metabolism in C6 Glioma Cells: Evidence for the Preferential Utilization of Lactate for Cell Oxidative Metabolism, 10.1159/000017328
  60. Bouzier-Sore Anne-Karine, Canioni Paul, Merle Michel, Effect of exogenous lactate on rat glioma metabolism, 10.1002/jnr.1184
  61. Manning James E., Katz Laurence M., Brownstein Michelle R., Pearce Bruce L., Gawryl Maria S., Baker Christopher C., BOVINE HEMOGLOBIN-BASED OXYGEN CARRIER (HBOC-201) FOR RESUSCITATION OF UNCONTROLLED, EXSANGUINATING LIVER INJURY IN SWINE : , 10.1097/00024382-200013020-00010
  62. Halestrap AP (2008) Inhibiting lactate oxidation in tumor cells. eLetters: The Journal of Clinical Investigation.
  63. Halestrap A P, The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors, 10.1042/bj1480085
  64. Sonveaux Pierre, Copetti Tamara, De Saedeleer Christophe J., Végran Frédérique, Verrax Julien, Kennedy Kelly M., Moon Eui Jung, Dhup Suveera, Danhier Pierre, Frérart Françoise, Gallez Bernard, Ribeiro Anthony, Michiels Carine, Dewhirst Mark W., Feron Olivier, Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis, 10.1371/journal.pone.0033418
  65. Kumar Ajay, Kant Shiva, Singh Sukh Mahendra, α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton’s lymphoma cells : role of altered cell survival-regulatory mechanisms, 10.1097/cad.0b013e3283586743
  66. Zielke H. Ronald, Sumbilla Carlota M., Sevdalian David A., Hawkins Robert L., Ozand Pinar T., Lactate: A major product of glutamine metabolism by human diploid fibroblasts, 10.1002/jcp.1041040316
  67. LJ Reitzer, J Biol Chem, 254, 2669 (1979)
  68. Marín-Hernández Alvaro, Gallardo-Pérez Juan Carlos, Rodríguez-Enríquez Sara, Encalada Rusely, Moreno-Sánchez Rafael, Saavedra Emma, Modeling cancer glycolysis, 10.1016/j.bbabio.2010.11.006
  69. J Rasschaert, Int J Mol Med, 8, 63 (2001)
  70. Favaro Elena, Bensaad Karim, Chong Mei G., Tennant Daniel A., Ferguson David J.P., Snell Cameron, Steers Graham, Turley Helen, Li Ji-Liang, Günther Ulrich L., Buffa Francesca M., McIntyre Alan, Harris Adrian L., Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells, 10.1016/j.cmet.2012.10.017
  71. Front Pharmacol, 2, 49
  72. Herrero P., Dence C. S., Coggan A. R., Kisrieva-Ware Z., Eisenbeis P., Gropler R. J., L-3-11C-Lactate as a PET Tracer of Myocardial Lactate Metabolism: A Feasibility Study, 10.2967/jnumed.107.044503
  73. Felig P., Pozefsk T., Marlis E., Cahill G. F., Alanine: Key Role in Gluconeogenesis, 10.1126/science.167.3920.1003
  74. Vaupel Peter, Tumor microenvironmental physiology and its implications for radiation oncology, 10.1016/j.semradonc.2004.04.008
  75. De Saedeleer Christophe J., Copetti Tamara, Porporato Paolo E., Verrax Julien, Feron Olivier, Sonveaux Pierre, Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells, 10.1371/journal.pone.0046571
  76. Aging (Albany NY), 2, 185
  77. Pavlides Stephanos, Vera Iset, Gandara Ricardo, Sneddon Sharon, Pestell Richard G., Mercier Isabelle, Martinez-Outschoorn Ubaldo E., Whitaker-Menezes Diana, Howell Anthony, Sotgia Federica, Lisanti Michael P., Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and MetastasisviaOxidative Stress, Mitophagy, and Aerobic Glycolysis, 10.1089/ars.2011.4243
  78. Pavlides Stephanos, Whitaker-Menezes Diana, Castello-Cros Remedios, Flomenberg Neal, Witkiewicz Agnieszka K., Frank Philippe G., Casimiro Mathew C., Wang Chenguang, Fortina Paolo, Addya Sankar, Pestell Richard G., Martinez-Outschoorn Ubaldo E., Sotgia Federica, Lisanti Michael P., The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma, 10.4161/cc.8.23.10238
  79. Bonuccelli Gloria, Whitaker-Menezes Diana, Castello-Cros Remedios, Pavlides Stephanos, Pestell Richard G., Fatatis Alessandro, Witkiewicz Agnieszka K., Vander Heiden Matthew G., Migneco Gemma, Chiavarina Barbara, Frank Philippe G., Capozza Franco, Flomenberg Neal, Martinez-Outschoorn Ubaldo E., Sotgia Federica, Lisanti Michael P., The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts, 10.4161/cc.9.10.11601
  80. Birsoy Kivanç, Wang Tim, Possemato Richard, Yilmaz Omer H, Koch Catherine E, Chen Walter W, Hutchins Amanda W, Gultekin Yetis, Peterson Tim R, Carette Jan E, Brummelkamp Thijn R, Clish Clary B, Sabatini David M, MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors, 10.1038/ng.2471
  81. Dhup Suveera, Kumar Dadhich Rajesh, Ettore Porporato Paolo, Sonveaux Pierre, Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis, 10.2174/138161212799504902
  82. Diers Anne R., Broniowska Katarzyna A., Chang Ching-Fang, Hogg Neil, Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition, 10.1042/bj20120294
  83. Mikkelsen Mark E., Miltiades Andrea N., Gaieski David F., Goyal Munish, Fuchs Barry D., Shah Chirag V., Bellamy Scarlett L., Christie Jason D., Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock* : , 10.1097/ccm.0b013e31819fcf68
  84. Genton B., Berger J. P., Cerebrospinal fluid lactate in 78 cases of adult meningitis, 10.1007/bf01724802
  85. Kim Howard S., Masko Elizabeth M., Poulton Susan L., Kennedy Kelly M., Pizzo Salvatore V., Dewhirst Mark W., Freedland Stephen J., Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer : CARBOHYDRATE RESTRICTION AND LACTATE TRANSPORTER INHIBITION IN PROSTATE CANCER, 10.1111/j.1464-410x.2012.10971.x
  86. Yaligar J., Thakur S. B., Bokacheva L., Carlin S., Thaler H. T., Rizwan A., Lupu M. E., Wang Y., Matei C. C., Zakian K. L., Koutcher J. A., Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness : LACTATE IMAGING AND DCE MRI IN PROSTATE TUMORS, 10.1002/nbm.1723
  87. Oshida Masaki, Uno Kimiichi, Suzuki Masato, Nagashima Takeshi, Hashimoto Hideyuki, Yagata Hiroshi, Shishikura Tanetomo, Imazeki Keiko, Nakajima Nobuyuki, Predicting the prognoses of breast carcinoma patients with positron emission tomography using 2-deoxy-2-fluoro[18F]-D-glucose, 10.1002/(sici)1097-0142(19980601)82:11<2227::aid-cncr18>;2-w
  88. Richardson Rachel A., Dewhirst Mark W., The Effect of Nicotinamide & Hyperoxic Gases on Blood Glucose, Advances in Experimental Medicine and Biology (2003) ISBN:9781461349648 p.375-378, 10.1007/978-1-4615-0205-0_62