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JAK/STAT signaling in hematological malignancies

Bibliographic reference Vainchenker, W. ; Constantinescu, Stefan N.. JAK/STAT signaling in hematological malignancies. In: Oncogene : including Oncogene Reviews, Vol. 32, no.21, p. 2601-2613 (2013)
Permanent URL http://hdl.handle.net/2078.1/132795
  1. Velazquez Laura, Fellous Marc, Stark George R., Pellegrini Sandra, A protein tyrosine kinase in the interferon αβ signaling pathway, 10.1016/0092-8674(92)90105-l
  2. Darnell J., Kerr I., Stark G., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, 10.1126/science.8197455
  3. Remy I., Wilson I. A., Michnick S. W., Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change, 10.1126/science.283.5404.990
  4. Constantinescu S. N., Keren T., Socolovsky M., Nam H.-s., Henis Y. I., Lodish H. F., Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain, 10.1073/pnas.081069198
  5. Constantinescu Stefan N, Huang Lily Jun-shen, Nam Hyung-song, Lodish Harvey F, The Erythropoietin Receptor Cytosolic Juxtamembrane Domain Contains an Essential, Precisely Oriented, Hydrophobic Motif, 10.1016/s1097-2765(01)00185-x
  6. Brown Richard J, Adams Julian J, Pelekanos Rebecca A, Wan Yu, McKinstry William J, Palethorpe Kathryn, Seeber Ruth M, Monks Thea A, Eidne Karin A, Parker Michael W, Waters Michael J, Model for growth hormone receptor activation based on subunit rotation within a receptor dimer, 10.1038/nsmb977
  7. Thomas Christoph, Moraga Ignacio, Levin Doron, Krutzik Peter O., Podoplelova Yulia, Trejo Angelica, Lee Choongho, Yarden Ganit, Vleck Susan E., Glenn Jeffrey S., Nolan Garry P., Piehler Jacob, Schreiber Gideon, Garcia K. Christopher, Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons, 10.1016/j.cell.2011.06.048
  8. Ihle James N., The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling, Advances in Immunology Volume 60 (1995) ISBN:9780120224609 p.1-35, 10.1016/s0065-2776(08)60582-9
  9. Bromberg Jacqueline F, Wrzeszczynska Melissa H, Devgan Geeta, Zhao Yanxiang, Pestell Richard G, Albanese Chris, Darnell James E, Stat3 as an Oncogene, 10.1016/s0092-8674(00)81959-5
  10. Levy David E., Darnell J. E., Signalling: STATs: transcriptional control and biological impact, 10.1038/nrm909
  11. Migone T., Lin J., Cereseto A, Mulloy J., O'Shea J., Franchini G, Leonard W., Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I, 10.1126/science.7604283
  12. Weber-Nordt RM, Blood, 88, 809 (1996)
  13. Xia Z, Cancer Res, 58, 3173 (1998)
  14. Buettner R, Clin Cancer Res, 8, 945 (2002)
  15. Lacronique V., A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia, 10.1126/science.278.5341.1309
  16. BAXTER E, SCOTT L, CAMPBELL P, EAST C, FOUROUCLAS N, SWANTON S, VASSILIOU G, BENCH A, BOYD E, CURTIN N, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders, 10.1016/s0140-6736(05)74230-6
  17. James Chloé, Ugo Valérie, Le Couédic Jean-Pierre, Staerk Judith, Delhommeau François, Lacout Catherine, Garçon Loïc, Raslova Hana, Berger Roland, Bennaceur-Griscelli Annelise, Villeval Jean Luc, Constantinescu Stefan N., Casadevall Nicole, Vainchenker William, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera, 10.1038/nature03546
  18. Kralovics Robert, Passamonti Francesco, Buser Andreas S., Teo Soon-Siong, Tiedt Ralph, Passweg Jakob R., Tichelli Andre, Cazzola Mario, Skoda Radek C., A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders, 10.1056/nejmoa051113
  19. Levine Ross L., Wadleigh Martha, Cools Jan, Ebert Benjamin L., Wernig Gerlinde, Huntly Brian J.P., Boggon Titus J., Wlodarska Iwona, Clark Jennifer J., Moore Sandra, Adelsperger Jennifer, Koo Sumin, Lee Jeffrey C., Gabriel Stacey, Mercher Thomas, D’Andrea Alan, Fröhling Stefan, Döhner Konstanze, Marynen Peter, Vandenberghe Peter, Mesa Ruben A., Tefferi Ayalew, Griffin James D., Eck Michael J., Sellers William R., Meyerson Matthew, Golub Todd R., Lee Stephanie J., Gilliland D. Gary, Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis, 10.1016/j.ccr.2005.03.023
  20. Flex Elisabetta, Petrangeli Valentina, Stella Lorenzo, Chiaretti Sabina, Hornakova Tekla, Knoops Laurent, Ariola Cristina, Fodale Valentina, Clappier Emmanuelle, Paoloni Francesca, Martinelli Simone, Fragale Alessandra, Sanchez Massimo, Tavolaro Simona, Messina Monica, Cazzaniga Giovanni, Camera Andrea, Pizzolo Giovanni, Tornesello Assunta, Vignetti Marco, Battistini Angela, Cavé Hélène, Gelb Bruce D., Renauld Jean-Christophe, Biondi Andrea, Constantinescu Stefan N., Foà Robin, Tartaglia Marco, Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia, 10.1084/jem.20072182
  21. Tomasson M. H., Xiang Z., Walgren R., Zhao Y., Kasai Y., Miner T., Ries R. E., Lubman O., Fremont D. H., McLellan M. D., Payton J. E., Westervelt P., DiPersio J. F., Link D. C., Walter M. J., Graubert T. A., Watson M., Baty J., Heath S., Shannon W. D., Nagarajan R., Bloomfield C. D., Mardis E. R., Wilson R. K., Ley T. J., Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia, 10.1182/blood-2007-09-113027
  22. Xiang Z., Zhao Y., Mitaksov V., Fremont D. H., Kasai Y., Molitoris A., Ries R. E., Miner T. L., McLellan M. D., DiPersio J. F., Link D. C., Payton J. E., Graubert T. A., Watson M., Shannon W., Heath S. E., Nagarajan R., Mardis E. R., Wilson R. K., Ley T. J., Tomasson M. H., Identification of somatic JAK1 mutations in patients with acute myeloid leukemia, 10.1182/blood-2007-05-090308
  23. Mullighan C. G., Zhang J., Harvey R. C., Collins-Underwood J. R., Schulman B. A., Phillips L. A., Tasian S. K., Loh M. L., Su X., Liu W., Devidas M., Atlas S. R., Chen I-M., Clifford R. J., Gerhard D. S., Carroll W. L., Reaman G. H., Smith M., Downing J. R., Hunger S. P., Willman C. L., JAK mutations in high-risk childhood acute lymphoblastic leukemia, 10.1073/pnas.0811761106
  24. Pikman Yana, Lee Benjamin H, Mercher Thomas, McDowell Elizabeth, Ebert Benjamin L, Gozo Maricel, Cuker Adam, Wernig Gerlinde, Moore Sandra, Galinsky Ilene, DeAngelo Daniel J, Clark Jennifer J, Lee Stephanie J, Golub Todd R, Wadleigh Martha, Gilliland D. Gary, Levine Ross L, MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia, 10.1371/journal.pmed.0030270
  25. Mullighan Charles G, Collins-Underwood J Racquel, Phillips Letha A A, Loudin Michael G, Liu Wei, Zhang Jinghui, Ma Jing, Coustan-Smith Elaine, Harvey Richard C, Willman Cheryl L, Mikhail Fady M, Meyer Julia, Carroll Andrew J, Williams Richard T, Cheng Jinjun, Heerema Nyla A, Basso Giuseppe, Pession Andrea, Pui Ching-Hon, Raimondi Susana C, Hunger Stephen P, Downing James R, Carroll William L, Rabin Karen R, Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia, 10.1038/ng.469
  26. Russell L. J., Capasso M., Vater I., Akasaka T., Bernard O. A., Calasanz M. J., Chandrasekaran T., Chapiro E., Gesk S., Griffiths M., Guttery D. S., Haferlach C., Harder L., Heidenreich O., Irving J., Kearney L., Nguyen-Khac F., Machado L., Minto L., Majid A., Moorman A. V., Morrison H., Rand V., Strefford J. C., Schwab C., Tonnies H., Dyer M. J. S., Siebert R., Harrison C. J., Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia, 10.1182/blood-2009-03-208397
  27. Zenatti Priscila P, Ribeiro Daniel, Li Wenqing, Zuurbier Linda, Silva Milene C, Paganin Maddalena, Tritapoe Julia, Hixon Julie A, Silveira André B, Cardoso Bruno A, Sarmento Leonor M, Correia Nádia, Toribio Maria L, Kobarg Jörg, Horstmann Martin, Pieters Rob, Brandalise Silvia R, Ferrando Adolfo A, Meijerink Jules P, Durum Scott K, Yunes J Andrés, Barata João T, Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia, 10.1038/ng.924
  28. Oh S. T., Simonds E. F., Jones C., Hale M. B., Goltsev Y., Gibbs K. D., Merker J. D., Zehnder J. L., Nolan G. P., Gotlib J., Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms, 10.1182/blood-2010-02-270108
  29. Watowich Stephanie S., Wu Hong, Socolovsky Merav, Klingmuller Ursula, Constantinescu Stefan N., Lodish Harvey F., CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT, 10.1146/annurev.cellbio.12.1.91
  30. Huang Lily Jun-shen, Constantinescu Stefan N., Lodish Harvey F., The N-Terminal Domain of Janus Kinase 2 Is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor, 10.1016/s1097-2765(01)00401-4
  31. Radtke Simone, Hermanns Heike M., Haan Claude, Schmitz-Van de Leur Hildegard, Gascan Hugues, Heinrich Peter C., Behrmann Iris, Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression, 10.1074/jbc.m100822200
  32. Ragimbeau J., The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression, 10.1093/emboj/cdg038
  33. Royer Yohan, Staerk Judith, Costuleanu Marcel, Courtoy Pierre J., Constantinescu Stefan N., Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability, 10.1074/jbc.m501376200
  34. Syed Rashid S., Reid Scott W., Li Cuiwei, Cheetham Janet C., Aoki Kenneth H., Liu Beishan, Zhan Hangjun, Osslund Timothy D., Chirino Arthur J., Zhang Jiandong, Finer-Moore Janet, Elliott Steven, Sitney Karen, Katz Bradley A., Matthews David J., Wendoloski John J., Egrie Joan, Stroud Robert M., 10.1038/26773
  35. Vainchenker William, Dusa Alexandra, Constantinescu Stefan N., JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies, 10.1016/j.semcdb.2008.07.002
  36. Witthuhn Bruce A., Quelle Frederick W., Silvennoinen Olli, Yi Taolin, Tang Bo, Miura Osamu, Ihle James N., JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin, 10.1016/0092-8674(93)90414-l
  37. Drachman Jonathan G., Millett Kelly M., Kaushansky Kenneth, Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2, 10.1074/jbc.274.19.13480
  38. Touw Ivo, P., Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders, 10.2741/2103
  39. Shimoda K, Blood, 90, 597 (1997)
  40. Sattler M, Exp Hematol, 23, 1040 (1995)
  41. Drachman J. G., Kaushansky K., Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain, 10.1073/pnas.94.6.2350
  42. Constantinescu Stefan N., Ghaffari Saghi, Lodish Harvey F., The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction, 10.1016/s1043-2760(98)00101-5
  43. van de Geijn G.-J. M., G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact, 10.1182/blood-2003-08-2913
  44. Liao Wei, Lin Jian-Xin, Leonard Warren J, IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation, 10.1016/j.coi.2011.08.003
  45. Ghoreschi Kamran, Laurence Arian, O’Shea John J., Janus kinases in immune cell signaling, 10.1111/j.1600-065x.2008.00754.x
  46. Haan Claude, Rolvering Catherine, Raulf Friedrich, Kapp Manuela, Drückes Peter, Thoma Gebhard, Behrmann Iris, Zerwes Hans-Günter, Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors, 10.1016/j.chembiol.2011.01.012
  47. Demoulin Jean-Baptiste, Van Roost Emiel, Stevens Monique, Groner Bernd, Renauld Jean-Christophe, Distinct Roles for STAT1, STAT3, and STAT5 in Differentiation Gene Induction and Apoptosis Inhibition by Interleukin-9, 10.1074/jbc.274.36.25855
  48. Verdier Frédérique, Walrafen Pierre, Hubert Nathalie, Chrétien Stany, Gisselbrecht Sylvie, Lacombe Catherine, Mayeux Patrick, Proteasomes Regulate the Duration of Erythropoietin Receptor Activation by Controlling Down-regulation of Cell Surface Receptors, 10.1074/jbc.275.24.18375
  49. Gross Alec W., Lodish Harvey F., Cellular Trafficking and Degradation of Erythropoietin and Novel Erythropoiesis Stimulating Protein (NESP), 10.1074/jbc.m510493200
  50. Irandoust Mahban I, Aarts Lambertus H J, Roovers Onno, Gits Judith, Erkeland Stefan J, Touw Ivo P, Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor, 10.1038/sj.emboj.7601640
  51. Hitchcock I. S., Chen M. M., King J. R., Kaushansky K., YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation, 10.1182/blood-2008-01-134049
  52. Marijanovic Zrinka, Ragimbeau Josiane, Kumar K. G. Suresh, Fuchs Serge Y., Pellegrini Sandra, TYK2 activity promotes ligand-induced IFNAR1 proteolysis, 10.1042/bj20060272
  53. Klingmüller Ursula, Lorenz Ulrike, Cantley Lewis C, Neel Benjamin G, Lodish Harvey F, Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals, 10.1016/0092-8674(95)90351-8
  54. Sasaki Atsuo, Yasukawa Hideo, Shouda Takanori, Kitamura Toshio, Dikic Ivan, Yoshimura Akihiko, , CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2, 10.1074/jbc.m003456200
  55. Wang Q, Blood, 96, 2093 (2000)
  56. Jegalian Armin G., Wu Hong, Differential Roles of SOCS Family Members in EpoR Signal Transduction, 10.1089/107999002760274863
  57. Hörtner Michael, Nielsch Ulrich, Mayr Lorenz M., Heinrich Peter C., Haan Serge, A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor : SOCS-3 binds to the pY429pY431 motif of Epo-R, 10.1046/j.1432-1033.2002.02916.x
  58. Chaligné R, Tonetti C, Besancenot R, Marty C, Kiladjian J-J, Socié G, Bordessoule D, Vainchenker W, Giraudier S, SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis, 10.1038/leu.2009.22
  59. Palvimo J.J., PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription: Figure 1, 10.1042/bst0351405
  60. Zhou Shanggen, Si Junling, Liu Tong, DeWille James W., PIASy Represses CCAAT/Enhancer-binding Protein δ (C/EBPδ) Transcriptional Activity by Sequestering C/EBPδ to the Nuclear Periphery, 10.1074/jbc.m801307200
  61. Yoshimura Akihiko, Longmore Gregory, Lodish Harvey F., Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity, 10.1038/348647a0
  62. Alexander WS, EMBO J, 14, 5569 (1995)
  63. Longmore G, Leukemia, 7, S113 (1993)
  64. Peeters P, Blood, 90, 2535 (1997)
  65. Nguyen Melody H.-H., Ho Jenny M.-Y., Beattie Bryan K., Barber Dwayne L., TEL-JAK2 Mediates Constitutive Activation of the Phosphatidylinositol 3′-Kinase/Protein Kinase B Signaling Pathway, 10.1074/jbc.m103100200
  66. Schwaller Juerg, Frantsve Julie, Aster Jon, Williams Ifor R., Tomasson Michael H., Ross Theodora S., Peeters Pieter, Van Rompaey Luc, Van Etten Richard A., Ilaria Robert, Marynen Peter, Gilliland D.Gary, Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes, 10.1093/emboj/17.18.5321
  67. Kennedy J. A., Barabe F., Patterson B. J., Bayani J., Squire J. A., Barber D. L., Dick J. E., Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo, 10.1073/pnas.0604902103
  68. Reiter Andreas, Walz Christoph, Watmore Ann, Schoch Claudia, Blau Ilona, Schlegelberger Brigitte, Berger Ute, Telford Nick, Aruliah Shilani, Yin John A., Vanstraelen Danny, Barker Helen F., Taylor Peter C., O'Driscoll Aisling, Benedetti Fabio, Rudolph Cornelia, Kolb Hans-Jochem, Hochhaus Andreas, Hehlmann Rüdiger, Chase Andrew, Cross Nicholas C.P., The t(8;9)(p22;p24) Is a Recurrent Abnormality in Chronic and Acute Leukemia that FusesPCM1toJAK2, 10.1158/0008-5472.can-04-4263
  69. Murati A, Gelsi-Boyer V, Adélaïde J, Perot C, Talmant P, Giraudier S, Lodé L, Letessier A, Delaval B, Brunel V, Imbert M, Garand R, Xerri L, Birnbaum D, Mozziconacci M J, Chaffanet M, PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation, 10.1038/sj.leu.2403879
  70. Adélaïde J, Pérot C, Gelsi-Boyer V, Pautas C, Murati A, Copie-Bergman C, Imbert M, Chaffanet M, Birnbaum D, Mozziconacci M-J, A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma, 10.1038/sj.leu.2404104
  71. Cirmena Gabriella, Aliano Stefania, Fugazza Giuseppina, Bruzzone Roberto, Garuti Anna, Bocciardi Renata, Bacigalupo Andrea, Ravazzolo Roberto, Ballestrero Alberto, Sessarego Mario, A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia, 10.1016/j.cancergencyto.2008.02.005
  72. Poitras Jennifer L., Cin Paola Dal, Aster Jon C., DeAngelo Daniel J., Morton Cynthia C., NovelSSBP2-JAK2fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia, 10.1002/gcc.20585
  73. Nebral K, Denk D, Attarbaschi A, König M, Mann G, Haas O A, Strehl S, Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia, 10.1038/leu.2008.306
  74. Van Roosbroeck K., Cox L., Tousseyn T., Lahortiga I., Gielen O., Cauwelier B., De Paepe P., Verhoef G., Marynen P., Vandenberghe P., De Wolf-Peeters C., Cools J., Wlodarska I., JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma, 10.1182/blood-2010-06-291310
  75. Knoops L, Hornakova T, Royer Y, Constantinescu S N, Renauld J-C, JAK kinases overexpression promotes in vitro cell transformation, 10.1038/sj.onc.1210800
  76. Navarro A., Diaz T., Martinez A., Gaya A., Pons A., Gel B., Codony C., Ferrer G., Martinez C., Montserrat E., Monzo M., Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma, 10.1182/blood-2009-02-204842
  77. Weniger M A, Melzner I, Menz C K, Wegener S, Bucur A J, Dorsch K, Mattfeldt T, Barth T F E, Möller P, Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation, 10.1038/sj.onc.1209151
  78. Kleppe M., Tousseyn T., Geissinger E., Kalender Atak Z., Aerts S., Rosenwald A., Wlodarska I., Cools J., Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma, 10.3324/haematol.2011.041921
  79. Tefferi A., Classification, Diagnosis and Management of Myeloproliferative Disorders in the JAK2V617F Era, 10.1182/asheducation-2006.1.240
  80. Kralovics R, Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera, 10.1016/s0301-472x(01)00789-5
  81. Ungureanu Daniela, Wu Jinhua, Pekkala Tuija, Niranjan Yashavanthi, Young Clifford, Jensen Ole N, Xu Chong-Feng, Neubert Thomas A, Skoda Radek C, Hubbard Stevan R, Silvennoinen Olli, The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling, 10.1038/nsmb.2099
  82. Argetsinger L. S., Kouadio J.-L. K., Steen H., Stensballe A., Jensen O. N., Carter-Su C., Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity, 10.1128/mcb.24.11.4955-4967.2004
  83. Feener E. P., Rosario F., Dunn S. L., Stancheva Z., Myers M. G., Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling, 10.1128/mcb.24.11.4968-4978.2004
  84. Ishida-Takahashi R., Rosario F., Gong Y., Kopp K., Stancheva Z., Chen X., Feener E. P., Myers M. G., Phosphorylation of Jak2 on Ser523 Inhibits Jak2-Dependent Leptin Receptor Signaling, 10.1128/mcb.01589-05
  85. Lu Xiaohui, Huang Lily Jun-Shen, Lodish Harvey F., Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F, 10.1074/jbc.m707125200
  86. Chen Edwin, Beer Philip A., Godfrey Anna L., Ortmann Christina A., Li Juan, Costa-Pereira Ana P., Ingle Catherine E., Dermitzakis Emmanouil T., Campbell Peter J., Green Anthony R., Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling, 10.1016/j.ccr.2010.10.013
  87. Staerk Judith, Kallin Anders, Demoulin Jean-Baptiste, Vainchenker William, Constantinescu Stefan N., JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation : CROSS-TALK WITH IGF1 RECEPTOR, 10.1074/jbc.c500358200
  88. Lacout C., JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis, 10.1182/blood-2006-02-002030
  89. Tiedt R., Hao-Shen H., Sobas M. A., Looser R., Dirnhofer S., Schwaller J., Skoda R. C., Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice, 10.1182/blood-2007-08-107748
  90. Wernig G., Gonneville J. R., Crowley B. J., Rodrigues M. S., Reddy M. M., Hudon H. E., Walz C., Reiter A., Podar K., Royer Y., Constantinescu S. N., Tomasson M. H., Griffin J. D., Gilliland D. G., Sattler M., The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes, 10.1182/blood-2007-07-102186
  91. Akada H., Yan D., Zou H., Fiering S., Hutchison R. E., Mohi M. G., Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease, 10.1182/blood-2009-04-215848
  92. Li J., Spensberger D., Ahn J. S., Anand S., Beer P. A., Ghevaert C., Chen E., Forrai A., Scott L. M., Ferreira R., Campbell P. J., Watson S. P., Liu P., Erber W. N., Huntly B. J. P., Ottersbach K., Green A. R., JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia, 10.1182/blood-2009-12-259747
  93. Marty C., Lacout C., Martin A., Hasan S., Jacquot S., Birling M.-C., Vainchenker W., Villeval J.-L., Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice, 10.1182/blood-2009-12-257063
  94. Mullally Ann, Lane Steven W., Ball Brian, Megerdichian Christine, Okabe Rachel, Al-Shahrour Fatima, Paktinat Mahnaz, Haydu J. Erika, Housman Elizabeth, Lord Allegra M., Wernig Gerlinde, Kharas Michael G., Mercher Thomas, Kutok Jeffery L., Gilliland D. Gary, Ebert Benjamin L., Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells, 10.1016/j.ccr.2010.05.015
  95. Scott L. M., Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia, 10.1182/blood-2006-04-018259
  96. Dupont S., Masse A., James C., Teyssandier I., Lecluse Y., Larbret F., Ugo V., Saulnier P., Koscielny S., Le Couedic J. P., Casadevall N., Vainchenker W., Delhommeau F., The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera, 10.1182/blood-2006-10-054940
  97. Teofili L., Martini M., Cenci T., Petrucci G., Torti L., Storti S., Guidi F., Leone G., Larocca L. M., Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation, 10.1182/blood-2007-01-069237
  98. Ugo V, Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera, 10.1016/j.exphem.2003.11.003
  99. Garcon L., Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells, 10.1182/blood-2005-10-009514
  100. Walz C., Ahmed W., Lazarides K., Betancur M., Patel N., Hennighausen L., Zaleskas V. M., Van Etten R. A., Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice, 10.1182/blood-2011-12-397554
  101. Yan D., Hutchison R. E., Mohi G., Critical requirement for Stat5 in a mouse model of polycythemia vera, 10.1182/blood-2011-03-345215
  102. Yao Z., Cui Y., Watford W. T., Bream J. H., Yamaoka K., Hissong B. D., Li D., Durum S. K., Jiang Q., Bhandoola A., Hennighausen L., O'Shea J. J., Stat5a/b are essential for normal lymphoid development and differentiation, 10.1073/pnas.0507350103
  103. Hennighausen L., Robinson G. W., Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B, 10.1101/gad.1643908
  104. Harrison Claire, Verstovsek Srdan, McMullin Mary F., Mesa Ruben, Janus kinase Inhibition and its effect upon the therapeutic landscape for myelofibrosis: from palliation to cure?, 10.1111/j.1365-2141.2012.09108.x
  105. Tefferi Ayalew, Challenges Facing JAK Inhibitor Therapy for Myeloproliferative Neoplasms, 10.1056/nejme1115119
  106. Tefferi A., JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths, 10.1182/blood-2011-11-395228
  107. Carbuccia N, Murati A, Trouplin V, Brecqueville M, Adélaïde J, Rey J, Vainchenker W, Bernard O A, Chaffanet M, Vey N, Birnbaum D, Mozziconacci M J, Mutations of ASXL1 gene in myeloproliferative neoplasms, 10.1038/leu.2009.141
  108. Delhommeau François, Dupont Sabrina, Valle Véronique Della, James Chloé, Trannoy Severine, Massé Aline, Kosmider Olivier, Le Couedic Jean-Pierre, Robert Fabienne, Alberdi Antonio, Lécluse Yann, Plo Isabelle, Dreyfus François J., Marzac Christophe, Casadevall Nicole, Lacombe Catherine, Romana Serge P., Dessen Philippe, Soulier Jean, Viguié Franck, Fontenay Michaela, Vainchenker William, Bernard Olivier A., Mutation inTET2in Myeloid Cancers, 10.1056/nejmoa0810069
  109. Yoshida Kenichi, Sanada Masashi, Shiraishi Yuichi, Nowak Daniel, Nagata Yasunobu, Yamamoto Ryo, Sato Yusuke, Sato-Otsubo Aiko, Kon Ayana, Nagasaki Masao, Chalkidis George, Suzuki Yutaka, Shiosaka Masashi, Kawahata Ryoichiro, Yamaguchi Tomoyuki, Otsu Makoto, Obara Naoshi, Sakata-Yanagimoto Mamiko, Ishiyama Ken, Mori Hiraku, Nolte Florian, Hofmann Wolf-Karsten, Miyawaki Shuichi, Sugano Sumio, Haferlach Claudia, Koeffler H. Phillip, Shih Lee-Yung, Haferlach Torsten, Chiba Shigeru, Nakauchi Hiromitsu, Miyano Satoru, Ogawa Seishi, Frequent pathway mutations of splicing machinery in myelodysplasia, 10.1038/nature10496
  110. Papaemmanuil E., Cazzola M., Boultwood J., Malcovati L., Vyas P., Bowen D., Pellagatti A., Wainscoat J.S., Hellstrom-Lindberg E., Gambacorti-Passerini C., Godfrey A.L., Rapado I., Cvejic A., Rance R., McGee C., Ellis P., Mudie L.J., Stephens P.J., McLaren S., Massie C.E., Tarpey P.S., Varela I., Nik-Zainal S., Davies H.R., Shlien A., Jones D., Raine K., Hinton J., Butler A.P., Teague J.W., Baxter E.J., Score J., Galli A., Della Porta M.G., Travaglino E., Groves M., Tauro S., Munshi N.C., Anderson K.C., El-Naggar A., Fischer A., Mustonen V., Warren A.J., Cross N.C.P., Green A.R., Futreal P.A., Stratton M.R., Campbell P.J., SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts, 10.1056/nejmoa1103283
  111. Malcovati L., Della Porta M. G., Pietra D., Boveri E., Pellagatti A., Galli A., Travaglino E., Brisci A., Rumi E., Passamonti F., Invernizzi R., Cremonesi L., Boultwood J., Wainscoat J. S., Hellstrom-Lindberg E., Cazzola M., Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis, 10.1182/blood-2009-05-222331
  112. Hookham M. B., Elliott J., Suessmuth Y., Staerk J., Ward A. C., Vainchenker W., Percy M. J., McMullin M. F., Constantinescu S. N., Johnston J. A., The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3, 10.1182/blood-2006-08-039735
  113. Liu Fan, Zhao Xinyang, Perna Fabiana, Wang Lan, Koppikar Priya, Abdel-Wahab Omar, Harr Michael W., Levine Ross L., Xu Hao, Tefferi Ayalew, Deblasio Anthony, Hatlen Megan, Menendez Silvia, Nimer Stephen D., JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation, 10.1016/j.ccr.2010.12.020
  114. Wrighton Katharine H., Cell signalling: PRMT5 restricts ERK activity, 10.1038/nrm3213
  115. Kanade Santosh R., Eckert Richard L., Protein Arginine Methyltransferase 5 (PRMT5) Signaling Suppresses Protein Kinase Cδ- and p38δ-dependent Signaling and Keratinocyte Differentiation, 10.1074/jbc.m111.331660
  116. Dawson Mark A., Bannister Andrew J., Göttgens Berthold, Foster Samuel D., Bartke Till, Green Anthony R., Kouzarides Tony, JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin, 10.1038/nature08448
  117. Besancenot Rodolphe, Chaligné Ronan, Tonetti Carole, Pasquier Florence, Marty Caroline, Lécluse Yann, Vainchenker William, Constantinescu Stefan N., Giraudier Stéphane, A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation, 10.1371/journal.pbio.1000476
  118. Pecquet C., Diaconu C. C., Staerk J., Girardot M., Marty C., Royer Y., Defour J.-P., Dusa A., Besancenot R., Giraudier S., Villeval J.-L., Knoops L., Courtoy P. J., Vainchenker W., Constantinescu S. N., Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes, 10.1182/blood-2011-08-372524
  119. Marubayashi Sachie, Koppikar Priya, Taldone Tony, Abdel-Wahab Omar, West Nathan, Bhagwat Neha, Caldas-Lopes Eloisi, Ross Kenneth N., Gönen Mithat, Gozman Alex, Ahn James H., Rodina Anna, Ouerfelli Ouathek, Yang Guangbin, Hedvat Cyrus, Bradner James E., Chiosis Gabriela, Levine Ross L., HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans, 10.1172/jci42442
  120. Dusa Alexandra, Mouton Céline, Pecquet Christian, Herman Murielle, Constantinescu Stefan N., JAK2 V617F Constitutive Activation Requires JH2 Residue F595: A Pseudokinase Domain Target for Specific Inhibitors, 10.1371/journal.pone.0011157
  121. Dusa Alexandra, Staerk Judith, Elliott Joanne, Pecquet Christian, Poirel Hélène A., Johnston James A., Constantinescu Stefan N., Substitution of Pseudokinase Domain Residue Val-617 by Large Non-polar Amino Acids Causes Activation of JAK2, 10.1074/jbc.m709302200
  122. Ma Wanlong, Kantarjian Hagop, Zhang Xi, Yeh Chen-Hsiung, Zhang Zhong J., Verstovsek Srdan, Albitar Maher, Mutation Profile of JAK2 Transcripts in Patients with Chronic Myeloproliferative Neoplasias, 10.2353/jmoldx.2009.080114
  123. Mead Adam J., Rugless Michelle J., Jacobsen Sten Eirik W., Schuh Anna, GermlineJAK2Mutation in a Family with Hereditary Thrombocytosis, 10.1056/nejmc1200349
  124. Scott Linda M., Tong Wei, Levine Ross L., Scott Mike A., Beer Philip A., Stratton Michael R., Futreal P. Andrew, Erber Wendy N., McMullin Mary Frances, Harrison Claire N., Warren Alan J., Gilliland D. Gary, Lodish Harvey F., Green Anthony R., JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis, 10.1056/nejmoa065202
  125. Klampfl T., Harutyunyan A., Berg T., Gisslinger B., Schalling M., Bagienski K., Olcaydu D., Passamonti F., Rumi E., Pietra D., Jager R., Pieri L., Guglielmelli P., Iacobucci I., Martinelli G., Cazzola M., Vannucchi A. M., Gisslinger H., Kralovics R., Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression, 10.1182/blood-2011-01-331678
  126. Passamonti F., Elena C., Schnittger S., Skoda R. C., Green A. R., Girodon F., Kiladjian J.-J., McMullin M. F., Ruggeri M., Besses C., Vannucchi A. M., Lippert E., Gisslinger H., Rumi E., Lehmann T., Ortmann C. A., Pietra D., Pascutto C., Haferlach T., Cazzola M., Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations, 10.1182/blood-2010-11-316810
  127. Malinge S., Ben-Abdelali R., Settegrana C., Radford-Weiss I., Debre M., Beldjord K., Macintyre E. A., Villeval J.-L., Vainchenker W., Berger R., Bernard O. A., Delabesse E., Penard-Lacronique V., Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia, 10.1182/blood-2006-09-045963
  128. Kearney L., Gonzalez De Castro D., Yeung J., Procter J., Horsley S. W., Eguchi-Ishimae M., Bateman C. M., Anderson K., Chaplin T., Young B. D., Harrison C. J., Kempski H., Wai E. So C., Ford A. M., Greaves M., Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia, 10.1182/blood-2008-08-170928
  129. Gaikwad Amos, Rye Cassia L., Devidas Meenakshi, Heerema Nyla A., Carroll Andrew J., Izraeli Shai, Plon Sharon E., Basso Giuseppe, Pession Andrea, Rabin Karen R., Prevalence and clinical correlates ofJAK2mutations in Down syndrome acute lymphoblastic leukaemia, 10.1111/j.1365-2141.2008.07552.x
  130. Mullighan C. G., New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice, 10.1158/1078-0432.ccr-10-1203
  131. Chen I.-M., Harvey R. C., Mullighan C. G., Gastier-Foster J., Wharton W., Kang H., Borowitz M. J., Camitta B. M., Carroll A. J., Devidas M., Pullen D. J., Payne-Turner D., Tasian S. K., Reshmi S., Cottrell C. E., Reaman G. H., Bowman W. P., Carroll W. L., Loh M. L., Winick N. J., Hunger S. P., Willman C. L., Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study, 10.1182/blood-2011-11-394221
  132. Malinge S., Ragu C., Della-Valle V., Pisani D., Constantinescu S. N., Perez C., Villeval J.-L., Reinhardt D., Landman-Parker J., Michaux L., Dastugue N., Baruchel A., Vainchenker W., Bourquin J.-P., Penard-Lacronique V., Bernard O. A., Activating mutations in human acute megakaryoblastic leukemia, 10.1182/blood-2008-01-136366
  133. Zhang Jinghui, Ding Li, Holmfeldt Linda, Wu Gang, Heatley Sue L., Payne-Turner Debbie, Easton John, Chen Xiang, Wang Jianmin, Rusch Michael, Lu Charles, Chen Shann-Ching, Wei Lei, Collins-Underwood J. Racquel, Ma Jing, Roberts Kathryn G., Pounds Stanley B., Ulyanov Anatoly, Becksfort Jared, Gupta Pankaj, Huether Robert, Kriwacki Richard W., Parker Matthew, McGoldrick Daniel J., Zhao David, Alford Daniel, Espy Stephen, Bobba Kiran Chand, Song Guangchun, Pei Deqing, Cheng Cheng, Roberts Stefan, Barbato Michael I., Campana Dario, Coustan-Smith Elaine, Shurtleff Sheila A., Raimondi Susana C., Kleppe Maria, Cools Jan, Shimano Kristin A., Hermiston Michelle L., Doulatov Sergei, Eppert Kolja, Laurenti Elisa, Notta Faiyaz, Dick John E., Basso Giuseppe, Hunger Stephen P., Loh Mignon L., Devidas Meenakshi, Wood Brent, Winter Stuart, Dunsmore Kimberley P., Fulton Robert S., Fulton Lucinda L., Hong Xin, Harris Christopher C., Dooling David J., Ochoa Kerri, Johnson Kimberly J., Obenauer John C., Evans William E., Pui Ching-Hon, Naeve Clayton W., Ley Timothy J., Mardis Elaine R., Wilson Richard K., Downing James R., Mullighan Charles G., The genetic basis of early T-cell precursor acute lymphoblastic leukaemia, 10.1038/nature10725
  134. Jeong E. G., Kim M. S., Nam H. K., Min C. K., Lee S., Chung Y. J., Yoo N. J., Lee S. H., Somatic Mutations of JAK1 and JAK3 in Acute Leukemias and Solid Cancers, 10.1158/1078-0432.ccr-07-4839
  135. Hornakova Tekla, Staerk Judith, Royer Yohan, Flex Elisabetta, Tartaglia Marco, Constantinescu Stefan N., Knoops Laurent, Renauld Jean-Christophe, Acute Lymphoblastic Leukemia-associated JAK1 Mutants Activate the Janus Kinase/STAT Pathway via Interleukin-9 Receptor α Homodimers, 10.1074/jbc.m807531200
  136. Kleppe M., Soulier J., Asnafi V., Mentens N., Hornakova T., Knoops L., Constantinescu S., Sigaux F., Meijerink J. P., Vandenberghe P., Tartaglia M., Foa R., Macintyre E., Haferlach T., Cools J., PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia, 10.1182/blood-2010-10-314286
  137. Porcu M., Kleppe M., Gianfelici V., Geerdens E., De Keersmaecker K., Tartaglia M., Foa R., Soulier J., Cauwelier B., Uyttebroeck A., Macintyre E., Vandenberghe P., Asnafi V., Cools J., Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia, 10.1182/blood-2011-09-379958
  138. Kameda T., Shide K., Shimoda H. K., Hidaka T., Kubuki Y., Katayose K., Taniguchi Y., Sekine M., Kamiunntenn A., Maeda K., Nagata K., Matsunaga T., Shimoda K., Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma, 10.1007/s12185-010-0653-2
  139. Elliott N. E., Cleveland S. M., Grann V., Janik J., Waldmann T. A., Dave U. P., FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma, 10.1182/blood-2010-12-319467
  140. Riera Ludovica, Lasorsa Elena, Bonello Lisa, Sismondi Francesca, Tondat Fabrizio, Di Bello Cristiana, Di Celle Paola Francia, Chiarle Roberto, Godio Laura, Pich Achille, Facchetti Fabio, Ponzoni Maurilio, Marmont Filippo, Zanon Carlo, Bardelli Alberto, Inghirami Giorgio, Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects, 10.3109/10428194.2011.574757
  141. Walters Denise K., Mercher Thomas, Gu Ting-Lei, O'Hare Thomas, Tyner Jeffrey W., Loriaux Marc, Goss Valerie L., Lee Kimberly A., Eide Christopher A., Wong Matthew J., Stoffregen Eric P., McGreevey Laura, Nardone Julie, Moore Sandra A., Crispino John, Boggon Titus J., Heinrich Michael C., Deininger Michael W., Polakiewicz Roberto D., Gilliland D. Gary, Druker Brian J., Activating alleles of JAK3 in acute megakaryoblastic leukemia, 10.1016/j.ccr.2006.06.002
  142. Kaminker J. S., Zhang Y., Waugh A., Haverty P. M., Peters B., Sebisanovic D., Stinson J., Forrest W. F., Bazan J. F., Seshagiri S., Zhang Z., Distinguishing Cancer-Associated Missense Mutations from Common Polymorphisms, 10.1158/0008-5472.can-06-1736
  143. Jones Amy V, Chase Andrew, Silver Richard T, Oscier David, Zoi Katerina, Wang Y Lynn, Cario Holger, Pahl Heike L, Collins Andrew, Reiter Andreas, Grand Francis, Cross Nicholas C P, JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms, 10.1038/ng.334
  144. Olcaydu Damla, Harutyunyan Ashot, Jäger Roland, Berg Tiina, Gisslinger Bettina, Pabinger Ingrid, Gisslinger Heinz, Kralovics Robert, A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms, 10.1038/ng.341
  145. Kilpivaara Outi, Mukherjee Semanti, Schram Alison M, Wadleigh Martha, Mullally Ann, Ebert Benjamin L, Bass Adam, Marubayashi Sachie, Heguy Adriana, Garcia-Manero Guillermo, Kantarjian Hagop, Offit Kenneth, Stone Richard M, Gilliland D Gary, Klein Robert J, Levine Ross L, A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms, 10.1038/ng.342
  146. Ritz O., Guiter C., Castellano F., Dorsch K., Melzner J., Jais J.-P., Dubois G., Gaulard P., Moller P., Leroy K., Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma, 10.1182/blood-2009-03-209759
  147. Baus D, Nonnenmacher F, Jankowski S, Döring C, Bräutigam C, Frank M, Hansmann M-L, Pfitzner E, STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line, 10.1038/leu.2009.103
  148. Nault Jean Charles, Fabre Monique, Couchy Gabrielle, Pilati Camilla, Jeannot Emmanuelle, Tran Van Nhieu Jeanne, Saint-Paul Marie-Christine, De Muret Anne, Redon Marie-José, Buffet Catherine, Salenave Sylvie, Balabaud Charles, Prevot Sophie, Labrune Philippe, Bioulac-Sage Paulette, Scoazec Jean-Yves, Chanson Philippe, Zucman-Rossi Jessica, GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation, 10.1016/j.jhep.2011.07.018
  149. Koskela Hanna L.M., Eldfors Samuli, Ellonen Pekka, van Adrichem Arjan J., Kuusanmäki Heikki, Andersson Emma I., Lagström Sonja, Clemente Michael J., Olson Thomas, Jalkanen Sari E., Majumder Muntasir Mamun, Almusa Henrikki, Edgren Henrik, Lepistö Maija, Mattila Pirkko, Guinta Kathryn, Koistinen Pirjo, Kuittinen Taru, Penttinen Kati, Parsons Alun, Knowles Jonathan, Saarela Janna, Wennerberg Krister, Kallioniemi Olli, Porkka Kimmo, Loughran Thomas P., Heckman Caroline A., Maciejewski Jaroslaw P., Mustjoki Satu, SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia, 10.1056/nejmoa1114885
  150. Pardanani A. D., Levine R. L., Lasho T., Pikman Y., Mesa R. A., Wadleigh M., Steensma D. P., Elliott M. A., Wolanskyj A. P., Hogan W. J., McClure R. F., Litzow M. R., Gilliland D. G., Tefferi A., MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients, 10.1182/blood-2006-04-018879
  151. Beer P. A., Campbell P. J., Scott L. M., Bench A. J., Erber W. N., Bareford D., Wilkins B. S., Reilly J. T., Hasselbalch H. C., Bowman R., Wheatley K., Buck G., Harrison C. N., Green A. R., MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort, 10.1182/blood-2008-01-131664
  152. Boyd Elaine M., Bench Anthony J., Goday-Fernández Andrea, Anand Shubha, Vaghela Krishna J., Beer Phillip, Scott Mike A., Bareford David, Green Anthony R., Huntly Brian, Erber Wendy N., Clinical utility of routineMPLexon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis, 10.1111/j.1365-2141.2010.08083.x
  153. Pecquet C., Staerk J., Chaligne R., Goss V., Lee K. A., Zhang X., Rush J., Van Hees J., Poirel H. A., Scheiff J.-M., Vainchenker W., Giraudier S., Polakiewicz R. D., Constantinescu S. N., Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor, 10.1182/blood-2008-10-183558
  154. Staerk J., An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor, 10.1182/blood-2005-06-2600
  155. Ding J., Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin, 10.1182/blood-2003-10-3471
  156. Chaligné R, Tonetti C, Besancenot R, Roy L, Marty C, Mossuz P, Kiladjian J-J, Socié G, Bordessoule D, Le Bousse-Kerdilès M-C, Vainchenker W, Giraudier S, New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition, 10.1038/leu.2008.137
  157. Hussein K, Bock O, Theophile K, Schulz-Bischof K, Porwit A, Schlue J, Jonigk D, Kreipe H, MPLW515L mutation in acute megakaryoblastic leukaemia, 10.1038/leu.2008.371
  158. Shochat Chen, Tal Noa, Bandapalli Obul R., Palmi Chiara, Ganmore Ithamar, te Kronnie Geertruy, Cario Gunnar, Cazzaniga Giovanni, Kulozik Andreas E., Stanulla Martin, Schrappe Martin, Biondi Andrea, Basso Giuseppe, Bercovich Dani, Muckenthaler Martina U., Izraeli Shai, Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias, 10.1084/jem.20110580
  159. Hertzberg L., Vendramini E., Ganmore I., Cazzaniga G., Schmitz M., Chalker J., Shiloh R., Iacobucci I., Shochat C., Zeligson S., Cario G., Stanulla M., Strehl S., Russell L. J., Harrison C. J., Bornhauser B., Yoda A., Rechavi G., Bercovich D., Borkhardt A., Kempski H., te Kronnie G., Bourquin J.-P., Domany E., Izraeli S., Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group, 10.1182/blood-2009-08-235408
  160. Forbes Louisa V, Gale Rosemary E, Pizzey Arnold, Pouwels Karin, Nathwani Amit, Linch David C, An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia, 10.1038/sj.onc.1205767
  161. Plo Isabelle, Zhang Yanyan, Le Couédic Jean-Pierre, Nakatake Mayuka, Boulet Jean-Michel, Itaya Miki, Smith Steven O., Debili Najet, Constantinescu Stefan N., Vainchenker William, Louache Fawzia, de Botton Stéphane, An activating mutation in theCSF3Rgene induces a hereditary chronic neutrophilia, 10.1084/jem.20090693
  162. Beekman R., Touw I. P., G-CSF and its receptor in myeloid malignancy, 10.1182/blood-2010-01-234120
  163. Beekman R., Valkhof M. G., Sanders M. A., van Strien P. M. H., Haanstra J. R., Broeders L., Geertsma-Kleinekoort W. M., Veerman A. J. P., Valk P. J. M., Verhaak R. G., Lowenberg B., Touw I. P., Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia, 10.1182/blood-2012-01-406116
  164. Golub Todd R., Barker George F., Lovett Michael, Gilliland D.Gary, Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation, 10.1016/0092-8674(94)90322-0
  165. Cools Jan, DeAngelo Daniel J., Gotlib Jason, Stover Elizabeth H., Legare Robert D., Cortes Jorges, Kutok Jeffrey, Clark Jennifer, Galinsky Ilene, Griffin James D., Cross Nicholas C.P., Tefferi Ayalew, Malone James, Alam Rafeul, Schrier Stanley L., Schmid Janet, Rose Michal, Vandenberghe Peter, Verhoef Gregor, Boogaerts Marc, Wlodarska Iwona, Kantarjian Hagop, Marynen Peter, Coutre Steven E., Stone Richard, Gilliland D. Gary, A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome, 10.1056/nejmoa025217
  166. Sternberg David W., Gilliland D. Gary, The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis, 10.1200/jco.2004.10.124
  167. Cain J. A., Xiang Z., O'Neal J., Kreisel F., Colson A., Luo H., Hennighausen L., Tomasson M. H., Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage, 10.1182/blood-2006-07-036335
  168. Toffalini F., Demoulin J.-B., New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases, 10.1182/blood-2010-04-279752
  169. Choudhary Chunaram, Müller-Tidow Carsten, Berdel Wolfgang E., Serve Hubert, Signal Transduction of Oncogenic Flt3, 10.1532/ijh97.05090
  170. Choudhary Chunaram, Olsen Jesper V., Brandts Christian, Cox Jürgen, Reddy Pavankumar N.G., Böhmer Frank D., Gerke Volker, Schmidt-Arras Dirk-E., Berdel Wolfgang E., Müller-Tidow Carsten, Mann Matthias, Serve Hubert, Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes, 10.1016/j.molcel.2009.09.019
  171. Lasho T, Tefferi A, Pardanani A, Inhibition of JAK–STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells, 10.1038/leu.2010.109
  172. Brender C, Lovato P, Sommer V H, Woetmann A, Mathiesen A-M, Geisler C, Wasik M, Ødum N, Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα, 10.1038/sj.leu.2403610
  173. Rudd CE, Sci STKE, 85, pe1 (2001)
  174. Lu X., Levine R., Tong W., Wernig G., Pikman Y., Zarnegar S., Gilliland D. G., Lodish H., Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation, 10.1073/pnas.0509714102
  175. Tong Wei, Lodish Harvey F., Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis, 10.1084/jem.20040762
  176. Velazquez Laura, Cheng Alec M., Fleming Heather E., Furlonger Caren, Vesely Shirly, Bernstein Alan, Paige Christopher J., Pawson Tony, Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted inLnk-deficient Mice, 10.1084/jem.20011883
  177. Pardanani A, Lasho T, Finke C, Oh S T, Gotlib J, Tefferi A, LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations, 10.1038/leu.2010.163
  178. Bersenev Alexey, Wu Chao, Balcerek Joanna, Jing Jiang, Kundu Mondira, Blobel Gerd A., Chikwava Kudakwashe R., Tong Wei, Lnk constrains myeloproliferative diseases in mice, 10.1172/jci42032
  179. Krebs DL, J Cell Sci, 113, 2813 (2000)
  180. Calabrese Viviane, Mallette Frédérick A., Deschênes-Simard Xavier, Ramanathan Sheela, Gagnon Julien, Moores Adrian, Ilangumaran Subburaj, Ferbeyre Gerardo, SOCS1 Links Cytokine Signaling to p53 and Senescence, 10.1016/j.molcel.2009.09.044
  181. Melzner I., Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line, 10.1182/blood-2004-09-3701
  182. Elliott J., Suessmuth Y., Scott L. M., Nahlik K., McMullin M. F., Constantinescu S. N., Green A. R., Johnston J. A., SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases, 10.3324/haematol.2008.002352
  183. Reddy Jyotsna, Shivapurkar Narayan, Takahashi Takao, Parikh Gunjan, Stastny Victor, Echebiri Chinyere, Crumrine Katherine, Zöchbauer-Müller Sabine, Drach Johannes, Zheng Yingye, Feng Ziding, Kroft Steven H, McKenna Robert W, Gazdar Adi F, Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors, 10.1038/sj.onc.1208032
  184. Teofili Luciana, Martini Maurizio, Cenci Tonia, Guidi Francesco, Torti Lorenza, Giona Fiorina, Foà Robin, Leone Giuseppe, Larocca Luigi Maria, Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases, 10.1002/ijc.23694
  185. Jost E, do Ó N, Dahl E, Maintz C E, Jousten P, Habets L, Wilop S, Herman J G, Osieka R, Galm O, Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders, 10.1038/sj.leu.2404513
  186. Irie-Sasaki Junko, Sasaki Takehiko, Matsumoto Wataru, Opavsky Anne, Cheng Mary, Welstead Grant, Griffiths Emily, Krawczyk Connie, Richardson Christopher D., Aitken Karen, Iscove Norman, Koretzky Gary, Johnson Pauline, Liu Peter, Rothstein David M., Penninger Josef M., 10.1038/35053086
  187. Harashima A., CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn, 10.1182/blood-2002-03-0864
  188. Braggio Esteban, Maiolino Angelo, Gouveia Maria E., Magalhães Roberto, Souto Filho João T., Garnica Márcia, Nucci Marcio, Renault Ilana Zalcberg, Methylation status of nine tumor suppressor genes in multiple myeloma, 10.1007/s12185-009-0459-2
  189. Chim Chor S., Kwong Yok L., Liang Raymond, Gene Hypermethylation in Multiple Myeloma: Lessons from a Cancer Pathway Approach, 10.3816/clm.2008.n.048
  190. Saur S. J., Sangkhae V., Geddis A. E., Kaushansky K., Hitchcock I. S., Ubiquitination and degradation of the thrombopoietin receptor c-Mpl, 10.1182/blood-2009-06-227033
  191. Bacher Ulrike, Haferlach Claudia, Schnittger Susanne, Kohlmann Alexander, Kern Wolfgang, Haferlach Torsten, Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies, 10.1007/s00277-010-0920-6
  192. Kales S. C., Ryan P. E., Nau M. M., Lipkowitz S., Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age, 10.1158/0008-5472.can-10-0610
  193. Grand F. H., Hidalgo-Curtis C. E., Ernst T., Zoi K., Zoi C., McGuire C., Kreil S., Jones A., Score J., Metzgeroth G., Oscier D., Hall A., Brandts C., Serve H., Reiter A., Chase A. J., Cross N. C. P., Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms, 10.1182/blood-2008-12-194548
  194. Bommert Kurt, Bargou Ralf C., Stühmer Thorsten, Signalling and survival pathways in multiple myeloma, 10.1016/j.ejca.2005.12.026
  195. Ishikawa Hideaki, Tsuyama Naohiro, Abroun Saeid, Liu Shangqin, Li Fu-Jun, Otsuyama Ken-Ichiro, Zheng Xu, Kawano Michio M., Interleukin-6, CD45 and the Src-Kinases in Myeloma Cell Proliferation, 10.1080/1042819031000097339
  196. Levy Y, Tsapis A, Brouet J C, Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines., 10.1172/jci115355
  197. Li Jun, Favata Margaret, Kelley Jennifer A., Caulder Eian, Thomas Beth, Wen Xiaoming, Sparks Richard B., Arvanitis Ari, Rogers James D., Combs Andrew P., Vaddi Kris, Solomon Kimberly A., Scherle Peggy A., Newton Robert, Fridman Jordan S., INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support, 10.1593/neo.91192
  198. Ramakrishnan Vijay, Kimlinger Teresa, Haug Jessica, Timm Michael, Wellik Linda, Halling Timothy, Pardanani Animesh, Tefferi Ayalew, Vincent Rajkumar Sundararasan, Kumar Shaji, TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells, 10.1002/ajh.21785
  199. Scuto A, Krejci P, Popplewell L, Wu J, Wang Y, Kujawski M, Kowolik C, Xin H, Chen L, Wang Y, Kretzner L, Yu H, Wilcox W R, Yen Y, Forman S, Jove R, The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival, 10.1038/leu.2010.289
  200. Warsch W., Kollmann K., Eckelhart E., Fajmann S., Cerny-Reiterer S., Holbl A., Gleixner K. V., Dworzak M., Mayerhofer M., Hoermann G., Herrmann H., Sillaber C., Egger G., Valent P., Moriggl R., Sexl V., High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia, 10.1182/blood-2009-10-248211
  201. Hantschel Oliver, Warsch Wolfgang, Eckelhart Eva, Kaupe Ines, Grebien Florian, Wagner Kay-Uwe, Superti-Furga Giulio, Sexl Veronika, BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia, 10.1038/nchembio.775
  202. Ozawa Yukiyasu, Williams Ann H., Estes Myka L., Matsushita Norimasa, Boschelli Frank, Jove Richard, List Alan F., Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT), 10.1016/j.leukres.2007.11.032
  203. Moucadel Virginie, Constantinescu Stefan N., Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors, 10.1074/jbc.m407326200
  204. Girardot M., Pecquet C., Boukour S., Knoops L., Ferrant A., Vainchenker W., Giraudier S., Constantinescu S. N., miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets, 10.1182/blood-2008-06-165985
  205. Pardanani Animesh, Gotlib Jason R., Jamieson Catriona, Cortes Jorge E., Talpaz Moshe, Stone Richard M., Silverman Michael H., Gilliland D. Gary, Shorr Jolene, Tefferi Ayalew, Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis, 10.1200/jco.2010.32.8021
  206. Santos FP, Blood [Clinical Trial, Phase II Research Support, Non-U.S. Gov't], 115, 1131 (2010)
  207. Verstovsek Srdan, Kantarjian Hagop, Mesa Ruben A., Pardanani Animesh D., Cortes-Franco Jorge, Thomas Deborah A., Estrov Zeev, Fridman Jordan S., Bradley Edward C., Erickson-Viitanen Susan, Vaddi Kris, Levy Richard, Tefferi Ayalew, Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis, 10.1056/nejmoa1002028
  208. Verstovsek Srdan, Kantarjian Hagop, Mesa Ruben A., Pardanani Animesh D., Cortes-Franco Jorge, Thomas Deborah A., Estrov Zeev, Fridman Jordan S., Bradley Edward C., Erickson-Viitanen Susan, Vaddi Kris, Levy Richard, Tefferi Ayalew, Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis, 10.1056/nejmoa1002028
  209. Verstovsek Srdan, Janus-Activated Kinase 2 Inhibitors: A New Era of Targeted Therapies Providing Significant Clinical Benefit for Philadelphia Chromosome–Negative Myeloproliferative Neoplasms, 10.1200/jco.2010.33.4508
  210. Verstovsek Srdan, Mesa Ruben A., Gotlib Jason, Levy Richard S., Gupta Vikas, DiPersio John F., Catalano John V., Deininger Michael, Miller Carole, Silver Richard T., Talpaz Moshe, Winton Elliott F., Harvey Jimmie H., Arcasoy Murat O., Hexner Elizabeth, Lyons Roger M., Paquette Ronald, Raza Azra, Vaddi Kris, Erickson-Viitanen Susan, Koumenis Iphigenia L., Sun William, Sandor Victor, Kantarjian Hagop M., A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis, 10.1056/nejmoa1110557
  211. Harrison Claire, Kiladjian Jean-Jacques, Al-Ali Haifa Kathrin, Gisslinger Heinz, Waltzman Roger, Stalbovskaya Viktoriya, McQuitty Mari, Hunter Deborah S., Levy Richard, Knoops Laurent, Cervantes Francisco, Vannucchi Alessandro M., Barbui Tiziano, Barosi Giovanni, JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis, 10.1056/nejmoa1110556
  212. Yoshihara Hiroki, Arai Fumio, Hosokawa Kentaro, Hagiwara Tetsuya, Takubo Keiyo, Nakamura Yuka, Gomei Yumiko, Iwasaki Hiroko, Matsuoka Sahoko, Miyamoto Kana, Miyazaki Hiroshi, Takahashi Takao, Suda Toshio, Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche, 10.1016/j.stem.2007.10.020
  213. Qian Hong, Buza-Vidas Natalija, Hyland Craig D., Jensen Christina T., Antonchuk Jennifer, Månsson Robert, Thoren Lina A., Ekblom Marja, Alexander Warren S., Jacobsen Sten Eirik W., Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells, 10.1016/j.stem.2007.10.008
  214. de Graaf C. A., Kauppi M., Baldwin T., D. Hyland C., Metcalf D., Willson T. A., Carpinelli M. R., Smyth G. K., Alexander W. S., Hilton D. J., Regulation of hematopoietic stem cells by their mature progeny, 10.1073/pnas.1016166108
  215. Rambaldi A, Br J Haematol, 150, 446 (2010)
  216. Hornakova T., Springuel L., Devreux J., Dusa A., Constantinescu S. N., Knoops L., Renauld J.-C., Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors, 10.3324/haematol.2010.036350
  217. Deshpande A, Reddy M M, Schade G O M, Ray A, Chowdary T K, Griffin J D, Sattler M, Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms, 10.1038/leu.2011.255
  218. Weigert Oliver, Lane Andrew A., Bird Liat, Kopp Nadja, Chapuy Bjoern, van Bodegom Diederik, Toms Angela V., Marubayashi Sachie, Christie Amanda L., McKeown Michael, Paranal Ronald M., Bradner James E., Yoda Akinori, Gaul Christoph, Vangrevelinghe Eric, Romanet Vincent, Murakami Masato, Tiedt Ralph, Ebel Nicolas, Evrot Emeline, De Pover Alain, Régnier Catherine H., Erdmann Dirk, Hofmann Francesco, Eck Michael J., Sallan Stephen E., Levine Ross L., Kung Andrew L., Baffert Fabienne, Radimerski Thomas, Weinstock David M., Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition, 10.1084/jem.20111694
  219. Guglielmelli P., Barosi G., Rambaldi A., Marchioli R., Masciulli A., Tozzi L., Biamonte F., Bartalucci N., Gattoni E., Lupo M. L., Finazzi G., Pancrazzi A., Antonioli E., Susini M. C., Pieri L., Malevolti E., Usala E., Occhini U., Grossi A., Caglio S., Paratore S., Bosi A., Barbui T., Vannucchi A. M., , Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis, 10.1182/blood-2011-01-330563
  220. Lu M., Wang J., Li Y., Berenzon D., Wang X., Mascarenhas J., Xu M., Hoffman R., Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon   specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells, 10.1182/blood-2010-04-279125
  221. Guglielmelli P., Biamonte F., Score J., Hidalgo-Curtis C., Cervantes F., Maffioli M., Fanelli T., Ernst T., Winkelman N., Jones A. V., Zoi K., Reiter A., Duncombe A., Villani L., Bosi A., Barosi G., Cross N. C. P., Vannucchi A. M., EZH2 mutational status predicts poor survival in myelofibrosis, 10.1182/blood-2011-06-363424
  222. Nelson E. A., Walker S. R., Weisberg E., Bar-Natan M., Barrett R., Gashin L. B., Terrell S., Klitgaard J. L., Santo L., Addorio M. R., Ebert B. L., Griffin J. D., Frank D. A., The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors, 10.1182/blood-2009-11-255232