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Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation

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Servais, Hélène [UCL] Ortiz, Alberto Devuyst, Olivier [UCL] Denamur, Sophie [UCL] Tulkens, Paul M. [UCL] Mingeot-Leclercq, Marie-Paule [UCL]

Apoptosis plays a central role not only in the physiological processes of kidney growth and remodeling, but also in various human renal diseases and drug-induced nephrotoxicity. We present in a synthetic fashion the main molecular and cellular pathways leading to drug-induced apoptosis in kidney and the mechanisms regulating it. We illustrate them using three main nephrotoxic drugs (cisplatin, gentamicin, and cyclosporine A). We discuss the main regulators and effectors that have emerged as key targets for the design of therapeutic strategies. Novel approaches using gene therapy, antisense strategies, recombinant proteins, or compounds obtained from both classical organic and combinatorial chemistry are examined. Finally, key issues that need to be addressed for the success of apoptosis-based therapies are underlined.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2008
Language Anglais
Journal information "Apoptosis : an international journal on programmed cell death" - Vol. 13, no. 1, p. 11-32 (2008)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York)
issn 1360-8185
e-issn 1573-675X
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/FARM - Ecole de pharmacie
UCL - (SLuc) Service de néphrologie
MESH Subject Animals ; Metabolic Networks and Pathways ; Mitochondria ; Renal Insufficiency ; Apoptosis ; Apoptosis Regulatory Proteins ; Caspases ; Cisplatin ; Cyclosporine ; Gentamicins ; Humans ; Kidney
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Bibliographic reference Servais, Hélène ; Ortiz, Alberto ; Devuyst, Olivier ; Denamur, Sophie ; Tulkens, Paul M. ; et. al. Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation. In: Apoptosis : an international journal on programmed cell death, Vol. 13, no. 1, p. 11-32 (2008)
Permanent URL http://hdl.handle.net/2078.1/131929