User menu

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

Bibliographic reference Tarasov, Andrei I ; Semplici, Francesca ; Ravier, Magalie A ; Bellomo, Elisa A ; Pullen, Timothy J ; et. al. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.. In: PLoS One, Vol. 7, no.7, p. e39722 [1-12] (2012)
Permanent URL
  1. Rutter G. A., Visualising insulin secretion. The Minkowski Lecture 2004, 10.1007/s00125-004-1541-1
  2. Mari A., , Tura A., Natali A., Laville M., Laakso M., Gabriel R., Beck-Nielsen H., Ferrannini E., Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance, 10.1007/s00125-009-1647-6
  3. Tarasov A. I., Nicolson T. J., Riveline J.-P., Taneja T. K., Baldwin S. A., Baldwin J. M., Charpentier G., Gautier J.-F., Froguel P., Vaxillaire M., Rutter G. A., A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and  -Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults, 10.2337/db07-1547
  4. Butler A. E., Janson J., Bonner-Weir S., Ritzel R., Rizza R. A., Butler P. C.,  -Cell Deficit and Increased  -Cell Apoptosis in Humans With Type 2 Diabetes, 10.2337/diabetes.52.1.102
  5. Maechler Pierre, Wollheim Claes B., Mitochondrial function in normal and diabetic β-cells, 10.1038/414807a
  6. Rutter Guy A., Nutrient–secretion coupling in the pancreatic islet β-cell: recent advances, 10.1016/s0098-2997(01)00013-9
  7. HJ Kennedy (1999)
  8. Ashcroft Frances M., Harrison Donna E., Ashcroft Stephen J. H., Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells, 10.1038/312446a0
  9. CB Wollheim, Physiol Rev, 61, 914 (1981)
  10. JG McCormack, Physiol Rev, 70, 391 (1990)
  11. G Hajnoczky (1995)
  12. Rutter Guy A., Ca2+ binding to citrate cycle dehydrogenases, 10.1016/0020-711x(90)90105-c
  13. WF Pralong, EMBO J, 9, 53 (1990)
  14. Wiederkehr Andreas, Szanda Gergő, Akhmedov Dmitry, Mataki Chikage, Heizmann Claus W., Schoonjans Kristina, Pozzan Tullio, Spät András, Wollheim Claes B., Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion, 10.1016/j.cmet.2011.03.015
  15. GA Rutter, J Biol Chem, 268, 22385 (1993)
  16. Eliasson Lena, Renström Erik, Ding Wei-Guang, Proks Peter, Rorsman Patrik, Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+-Induced Exocytosis in Mouse Pancreatic B-Cells, 10.1111/j.1469-7793.1997.399bh.x
  17. Ainscow E. K., Rutter G. A., Glucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet  -Cells: Evidence for a Ca2+-Dependent Mechanism, 10.2337/diabetes.51.2007.s162
  18. DETIMARY Philippe, GILON Patrick, HENQUIN Jean-Claude, Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets, 10.1042/bj3330269
  19. Göpel Sven O., Kanno Takahiro, Barg Sebastian, Eliasson Lena, Galvanovskis Juris, Renström Erik, Rorsman Patrik, Activation of Ca2+-Dependent K+Channels Contributes to Rhythmic Firing of Action Potentials in Mouse Pancreatic β Cells, 10.1085/jgp.114.6.759
  20. Nguyen Khanh T., García-Chacón Luis E., Barrett John N., Barrett Ellen F., David Gavriel, The Ψmdepolarization that accompanies mitochondrial Ca2+uptake is greater in mutant SOD1 than in wild-type mouse motor terminals, 10.1073/pnas.0810934106
  21. De Stefani Diego, Raffaello Anna, Teardo Enrico, Szabò Ildikò, Rizzuto Rosario, A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter, 10.1038/nature10230
  22. Baughman Joshua M., Perocchi Fabiana, Girgis Hany S., Plovanich Molly, Belcher-Timme Casey A., Sancak Yasemin, Bao X. Robert, Strittmatter Laura, Goldberger Olga, Bogorad Roman L., Koteliansky Victor, Mootha Vamsi K., Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter, 10.1038/nature10234
  23. Perocchi Fabiana, Gohil Vishal M., Girgis Hany S., Bao X. Robert, McCombs Janet E., Palmer Amy E., Mootha Vamsi K., MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake, 10.1038/nature09358
  24. Palty R., Silverman W. F., Hershfinkel M., Caporale T., Sensi S. L., Parnis J., Nolte C., Fishman D., Shoshan-Barmatz V., Herrmann S., Khananshvili D., Sekler I., NCLX is an essential component of mitochondrial Na+/Ca2+ exchange, 10.1073/pnas.0908099107
  25. Filippin Luisa, Abad Maria Cano, Gastaldello Stefano, Magalhães Paulo J., Sandonà Dorianna, Pozzan Tullio, Improved strategies for the delivery of GFP-based Ca2+ sensors into the mitochondrial matrix, 10.1016/j.ceca.2004.08.002
  26. Horn Richard, Korn Stephen J., [8] Prevention of rundown in electrophysiological recording, Methods in Enzymology (1992) ISBN:9780121821081 p.149-155, 10.1016/0076-6879(92)07010-l
  27. Eliasson L., Renstrom E., Ammala C., Berggren P.-O., Bertorello A. M., Bokvist K., Chibalin A., Deeney J. T., Flatt P. R., Gabel J., Gromada J., Larsson O., Lindstrom P., Rhodes C. J., Rorsman P., PKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic beta Cells, 10.1126/science.271.5250.813
  28. Berg Jim, Hung Yin Pun, Yellen Gary, A genetically encoded fluorescent reporter of ATP:ADP ratio, 10.1038/nmeth.1288
  29. Tarasov Andrei I., Girard Christophe A.J., Ashcroft Frances M., ATP Sensitivity of the ATP-Sensitive K+Channel in Intact and Permeabilized Pancreatic β-Cells, 10.2337/db06-0360
  30. MK Park (2001)
  31. Lee B., Miles P. D., Vargas L., Luan P., Glasco S., Kushnareva Y., Kornbrust E. S., Grako K. A., Wollheim C. B., Maechler P., Olefsky J. M., Anderson C. M., Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets, 10.2337/diabetes.52.4.965
  32. Luciani Dan S., Misler Stanley, Polonsky Kenneth S., Ca2+controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets : NAD(P)H and Ca2+oscillations in intact pancreatic islets, 10.1113/jphysiol.2005.101766
  33. Molina A. J.A., Wikstrom J. D., Stiles L., Las G., Mohamed H., Elorza A., Walzer G., Twig G., Katz S., Corkey B. E., Shirihai O. S., Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis, 10.2337/db07-1781
  34. , Mei Jie, Park Miejung, York David A., Erlanson-Albertsson Charlotte, Fatty acids and glucose in high concentration down-regulates ATP synthase β-subunit protein expression in INS-1 cells, 10.1080/10284150701745910
  35. Gremlich Sandrine, Bonny Christophe, Waeber Gerard, Thorens Bernard, Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels, 10.1074/jbc.272.48.30261
  36. P Gilon, J Biol Chem, 267, 20713 (1992)
  37. RH Chow, J Physiol 485 ( Pt, 3), 607 (1995)
  38. Gilon Patrick, Arredouani Abdelilah, Gailly Philippe, Gromada Jesper, Henquin Jean-Claude, Uptake and Release of Ca2+by the Endoplasmic Reticulum Contribute to the Oscillations of the Cytosolic Ca2+Concentration Triggered by Ca2+Influx in the Electrically Excitable Pancreatic B-cell, 10.1074/jbc.274.29.20197
  39. Jouaville L. S., Pinton P., Bastianutto C., Rutter G. A., Rizzuto R., Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming, 10.1073/pnas.96.24.13807
  40. AINSCOW Edward K., RUTTER Guy A., Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets, 10.1042/bj3530175
  41. Harris D A, Das A M, Control of mitochondrial ATP synthesis in the heart, 10.1042/bj2800561
  42. Takahashi N., Kadowaki T., Yazaki Y., Ellis-Davies G. C. R., Miyashita Y., Kasai H., Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells, 10.1073/pnas.96.2.760
  43. Tsuboi Takashi, da Silva Xavier Gabriela, Leclerc Isabelle, Rutter Guy A., 5′-AMP-activated Protein Kinase Controls Insulin-containing Secretory Vesicle Dynamics, 10.1074/jbc.m307800200
  44. Parton L. E., McMillen P. J., Shen Y., Docherty E., Sharpe E., Diraison F., Briscoe C. P., Rutter G. A., Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis, 10.1152/ajpendo.00067.2006
  45. Rutter Guy A., Tsuboi Takashi, Ravier Magalie A., Ca2+ microdomains and the control of insulin secretion, 10.1016/j.ceca.2006.08.015
  46. Ravier M. A., Rutter G. A., Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic  -Cells, 10.2337/diabetes.54.6.1789
  47. Luo Jinyong, Deng Zhong-Liang, Luo Xiaoji, Tang Ni, Song Wen-Xin, Chen Jin, Sharff Katie A, Luu Hue H, Haydon Rex C, Kinzler Kenneth W, Vogelstein Bert, He Tong-Chuan, A protocol for rapid generation of recombinant adenoviruses using the AdEasy system, 10.1038/nprot.2007.135
  48. Fink Charles, Morgan Frank, Loew Leslie M., Intracellular Fluorescent Probe Concentrations by Confocal Microscopy, 10.1016/s0006-3495(98)77607-6
  49. Tarasov A. I., Welters H. J., Senkel S., Ryffel G. U., Hattersley A. T., Morgan N. G., Ashcroft F. M., A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1  -Cells, 10.2337/db06-0637