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Shaping the nervous system: role of the core planar cell polarity genes.

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Tissir, Fadel [UCL] Goffinet, André [UCL]

Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and refers to the global coordination of cell behaviour in the plane of a tissue, and by extension to the signalling pathways that control it. PCP is most evident in cell sheets and research into PCP was for years confined to studies in Drosophila. However, PCP has more recently emerged as an important phenomenon in vertebrates where it regulates various developmental processes and is associated with multiple disorders. In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "Nature Reviews Neuroscience" - Vol. 14, p. 525–535 (2013)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1471-003X
e-issn 1471-0048
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Links
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Bibliographic reference Tissir, Fadel ; Goffinet, André. Shaping the nervous system: role of the core planar cell polarity genes.. In: Nature Reviews Neuroscience, Vol. 14, p. 525–535 (2013)
Permanent URL http://hdl.handle.net/2078.1/130050