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Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer's disease.

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Ivanoiu, Adrian [UCL] Adam, Stéphane [UCL] Van der Linden, Martial Salmon, Eric Juillerat, Anne-Claude Seron, Xavier [UCL]

Free delayed recall is considered the memory measure with the greatest sensitivity for the early diagnosis of dementia. However, its specificity for dementia could be lower, as deficits other than those of pure memory might account for poor performance in this difficult and effortful task. Cued recall is supposed to allow a better distinction between poor memory due to concurrent factors and impairments related to the neurodegenerative process. The available cued recall tests suffer from a ceiling effect. This is a prospective, longitudinal study aiming to assess the utility of a new memory test based on cued recall that avoids the ceiling effect in the early diagnosis of Alzheimer's disease (AD). Twenty-five patients with mild cognitive impairment (MCI), 22 probable AD patients (NINCDS-ADRDA) at a mild stage, 22 elderly patients with subjective memory complaints (SMC) and 38 normal age-matched controls took part in the study. The patients underwent a thorough cognitive evaluation and the recommended screening procedure for the diagnosis of dementia. All patients were re-examined 12-18 months later. A newly devised delayed cued recall test using semantic cues (The RI48 Test) was compared with three established memory tests: the Ten Word-List Recall from CERAD, the "Doors" and the "Shapes" Tests from "The Doors and People Test Battery". Forty-four % of the MCI patients fulfilled criteria for probable AD at follow-up. The RI48 Test classified correctly 88% of the MCI and SMC participants and was the best predictor of the status of MCI and mild AD as well as the outcome of the MCI patients. Poor visual memory was the second best predictor of those MCI patients who evolved to AD. A cued recall test which avoids the ceiling effect is at least as good as the delayed free recall tests in the early detection of AD.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Journal of Neurology : official journal of the European Neurological Society" - Vol. 252, no. 1, p. 47-55 (2005)
Peer reviewed yes
Publisher Dr. DietrichSteinkopff Verlag ((Germany) Heidelberg)
issn 0340-5354
e-issn 1432-1459
Publication status Publié
Affiliations UCL - MD/NOPS - Département de neurologie et de psychiatrie
UCL - (SLuc) Service de neurologie
MESH Subject Aged ; Alzheimer Disease - diagnosis - physiopathology - psychology ; Cognition Disorders - diagnosis - physiopathology - psychology ; Cues ; Female ; Humans ; Male ; Memory Disorders - diagnosis - physiopathology - psychology ; Neuropsychological Tests - standards ; Predictive Value of Tests ; Reproducibility of Results
Links
  1. Adam S, Van der Linden M, Poitrenaud J, Kalafat M, et les membres du GREMEM (2004) L?épreuve de rappel indicé à 48 items (RI-48). In: Van der Linden M, Adam S, Agniel A, Baisset Mouly C, et al. (eds) L?évaluation des troubles de la mémoire: Présentation de quatres tests de mémoire épisodique (avec leur étalonnage). Marseille: Solal
  2. Albert MS (1996) Cognitive and neurobiological markers of early Alzheimer disease. Proc Natl Acad Sci USA 93:13547?13551
  3. Baddeley A, Emslie H, Nimmo-Smith I (1994) Doors and People. Thames Valley Test Company
  4. Buschke H, Sliwinski MJ, Kuslansky G, Lipton RB (1997) Diagnosis of early dementia by the Double Memory Test: Encoding specificity improves diagnostic sensitivity and specificity. Neurology 48:989?997
  5. Buschke H (1984) Cued recall in amnesia. J Clin Exp Neuropsychol 6:433?440
  6. de Partz MP, Bilocq V, De Wilde V, Seron X, Pillon A (2001) LEXIS: Tests pour l?évaluation des troubles lexicaux chez la personne aphasique. Marseille: Solal
  7. Elias MF, Beiser A, Wolf PA, Au R, White RF, D?Agostino RB (2000) The preclinical phase of Alzheimer disease. A 22-year prospective study of the Framingham Cohort. Arch Neurol 57:808?813
  8. Ergis AM, Van der Linden M, Deweer B (1994) L?exploration des troubles de la mémoire épisodique dans la maladie d?Alzheimer débutante au moyen d?une épreuve de rappel indicé. Rev Neuropsychol 4:47?68
  9. Flicker C, Ferris SH, Reisberg B (1993) A longitudinal study of cognitive function in elderly persons with subjective memory complaints. J Am Geriatr Soc 41:1029?1032
  10. Folstein MF, Folstein SE, McHugh PR (1975) ?Mini Mental State?. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189?198
  11. Gifford D. R., Cummings J. L., Evaluating dementia screening tests, 10.1212/wnl.52.2.224
  12. Greene JDW, Baddeley AD, Hodges JR (1996) Analysis of the episodic memory deficit in early Alzheimer?s disease: evidence from the doors and people test. Neuropsychologia 34:537?551
  13. Grober E, Buschke H, Crystal H, Bang S, Dresner R (1988) Screening for dementia by memory testing. Neurology 38:900?903
  14. Grober E, Lipton RB, Hall C, Crystal H (2000) Memory impairment on free and cued selective reminding predicts dementia. Neurology 54:827?832
  15. Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143:29?36
  16. Hogrefe CJ (1962) Test d2. Göttingen: Verlag für Psychologie
  17. Hughes CP, Berg L, Danziger WL, Cohen LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:566?572
  18. Ivanoiu A, Adam S, Van der Linden M, et al. (2000) The episodic memory evaluation in incipient Alzheimer?s disease. J Neurol 247(Suppl 3):III/13 (Abstract)
  19. Ivanoiu A, Vanderlinden M, Seron X, Sindic CJM (1999) Contribution of free and cued recall to the early diagnosis of Alzheimer?s disease. J Neurol 246 (Suppl 1):I/122 (Abstract)
  20. Jonker C, Geerlings MI, Schmand B (2000) Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry 15:983?991
  21. Kertesz A, Mohs RC (1999) Cognition. In: Gauthier S (ed) Clinical Diagnosis and Management of Alzheimer?s Disease, 2nd ed. London: Martin Dunitz, Ltd., pp 179?196
  22. Mattis S (1988) Dementia Rating Scale: Professional manual. Odessa, FL: Psychological Assessment Resources
  23. McKhann G, Drachman D, Folstein M, et al. (1984) Clinical Diagnosis of Alzheimer?s disease. Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer?s disease. Neurology 34:939?944
  24. Meiran N, Stuss D, Guzman A, Lafleche G, Willmer J (1996) Diagnosis of dementia. Methods for interpretation of scores of 5 neuropsychological tests. Arch Neurol 53:1043?1054
  25. Morris JC, Mohs RC, Rogers H, Fillenbaum G, Heyman A (1988) Consortium to establish a registry for Alzheimer?s disease (CERAD). Clinical and neuropsychological assessment of Alzheimer?s disease. Psychopharmacol Bull 24:641?644
  26. Petersen RC, Smith GE, Ivnik RJ, Kokmen E, Tangalos EG (1994) Memory function in very early Alzheimer?s disease. Neurology 44:867?872
  27. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment. Clinical characterization and outcome. Arch Neurol 56:303?308
  28. Quality Standards Subcommittee of the American Academy of Neurology (1994) Practice parameter for diagnosis and evaluation of dementia (summary statement). Neurology 44:2203?2206
  29. Ritchie K, Fuhrer R (1992) A comparative study of the performance of screening tests for senile dementia using receiver operating characteristics analysis. J Clin Epidemiol 45:627?637
  30. Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K (1992) Quantitative and Qualitative Analyses of Clock Drawings in Alzheimer?s and Huntington Disease. Brain Cogn 18:70?87
  31. Small BJ, Fratiglioni L, Viitanen M, Winblad B, Backman L (2000) The course of cognitive impairment in preclinical Alzheimer disease. Three- and 6-year follow-up of a population-based sample. Arch Neurol 57:839?844
  32. StatView (1992?1994) Abacus Concepts, Inc.
  33. Tuokko H, Vernon-Wilkinson R, Weir J, Beattie BL (1991) Cued recall and early identification of dementia. J Clin Exp Neuropsychol 13:871?879
  34. Welsh K, Butters N, Hughes J, Mohs R, Heyman A (1991) Detection of abnormal memory decline in mild cases of Alzheimer?s disease using CERAD neuropsychological measures. Arch Neurol 48:278?281
Bibliographic reference Ivanoiu, Adrian ; Adam, Stéphane ; Van der Linden, Martial ; Salmon, Eric ; Juillerat, Anne-Claude ; et. al. Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer's disease.. In: Journal of Neurology : official journal of the European Neurological Society, Vol. 252, no. 1, p. 47-55 (2005)
Permanent URL http://hdl.handle.net/2078.1/12815