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IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect.

Bibliographic reference Couturier, M ; Lamarthée, B ; Arbez, J ; Renauld, Jean-Christophe ; Bossard, C ; et. al. IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect.. In: Leukemia, Vol. 27, p. 1527-1737 (2013)
Permanent URL http://hdl.handle.net/2078.1/126352
  1. Wingard John R., Majhail Navneet S., Brazauskas Ruta, Wang Zhiwei, Sobocinski Kathleen A., Jacobsohn David, Sorror Mohamed L., Horowitz Mary M., Bolwell Brian, Rizzo J. Douglas, Socié Gérard, Long-Term Survival and Late Deaths After Allogeneic Hematopoietic Cell Transplantation, 10.1200/jco.2010.33.7212
  2. Baron F, Labopin M, Niederwieser D, Vigouroux S, Cornelissen J J, Malm C, Vindelov L L, Blaise D, Janssen J J W M, Petersen E, Socié G, Nagler A, Rocha V, Mohty M, Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation, 10.1038/leu.2012.135
  3. Ferrara James LM, Levine John E, Reddy Pavan, Holler Ernst, Graft-versus-host disease, 10.1016/s0140-6736(09)60237-3
  4. Antin JH, Blood, 80, 2964 (1992)
  5. Mohty M., Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation, 10.1182/blood-2005-07-2919
  6. Blazar Bruce R., Murphy William J., Abedi Mehrdad, Advances in graft-versus-host disease biology and therapy, 10.1038/nri3212
  7. Kappel L. W., Goldberg G. L., King C. G., Suh D. Y., Smith O. M., Ligh C., Holland A. M., Grubin J., Mark N. M., Liu C., Iwakura Y., Heller G., van den Brink M. R. M., IL-17 contributes to CD4-mediated graft-versus-host disease, 10.1182/blood-2008-08-172155
  8. Carlson M. J., West M. L., Coghill J. M., Panoskaltsis-Mortari A., Blazar B. R., Serody J. S., In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations, 10.1182/blood-2008-06-162420
  9. Hanash A. M., Kappel L. W., Yim N. L., Nejat R. A., Goldberg G. L., Smith O. M., Rao U. K., Dykstra L., Na I.-K., Holland A. M., Dudakov J. A., Liu C., Murphy G. F., Leonard W. J., Heller G., van den Brink M. R. M., Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL, 10.1182/blood-2010-07-294785
  10. Bossard C, Malard F, Arbez J, Chevallier P, Guillaume T, Delaunay J, Mosnier J-F, Tiberghien P, Saas P, Mohty M, Gaugler B, Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease, 10.1038/leu.2012.41
  11. Renauld Jean-Christophe, Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators, 10.1038/nri1153
  12. Liang Spencer C., Tan Xiang-Yang, Luxenberg Deborah P., Karim Riyez, Dunussi-Joannopoulos Kyriaki, Collins Mary, Fouser Lynette A., Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides, 10.1084/jem.20061308
  13. Spits Hergen, Di Santo James P, The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling, 10.1038/ni.1962
  14. Wolk Kerstin, Kunz Stefanie, Witte Ellen, Friedrich Markus, Asadullah Khusru, Sabat Robert, IL-22 Increases the Innate Immunity of Tissues, 10.1016/j.immuni.2004.07.007
  15. Tachiiri A, Imamura R, Wang Y, Fukui M, Umemura M, Suda T, Genomic structure and inducible expression of the IL-22 receptor α chain in mice, 10.1038/sj.gene.6363934
  16. Boniface K., Bernard F.-X., Garcia M., Gurney A. L., Lecron J.-C., Morel F., IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes, 10.4049/jimmunol.174.6.3695
  17. Wolk Kerstin, Witte Ellen, Wallace Elizabeth, Döcke Wolf-Dietrich, Kunz Stefanie, Asadullah Khusru, Volk Hans-Dieter, Sterry Wolfram, Sabat Robert, IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis, 10.1002/eji.200535503
  18. Sugimoto K, J Clin Invest, 118, 534 (2008)
  19. Zenewicz Lauren A., Yancopoulos George D., Valenzuela David M., Murphy Andrew J., Stevens Sean, Flavell Richard A., Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease, 10.1016/j.immuni.2008.11.003
  20. Pickert Geethanjali, Neufert Clemens, Leppkes Moritz, Zheng Yan, Wittkopf Nadine, Warntjen Moritz, Lehr Hans-Anton, Hirth Sebastian, Weigmann Benno, Wirtz Stefan, Ouyang Wenjun, Neurath Markus F., Becker Christoph, STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing, 10.1084/jem.20082683
  21. Geboes Lies, Dumoutier Laure, Kelchtermans Hilde, Schurgers Evelien, Mitera Tania, Renauld Jean-Christophe, Matthys Patrick, Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice, 10.1002/art.24220
  22. Caproni M., Antiga E., Melani L., Volpi W., Del Bianco E., Fabbri P., Serum Levels of IL-17 and IL-22 Are Reduced by Etanercept, but not by Acitretin, in Patients with Psoriasis: a Randomized-Controlled Trial, 10.1007/s10875-008-9233-0
  23. Cooke KR, Blood, 88, 3230 (1996)
  24. Lerner KG, Transplant Proc, 6, 367 (1974)
  25. Hill GR, Blood, 90, 3204 (1997)
  26. Pan L, Blood, 93, 4071 (1999)
  27. Liang S. C., Nickerson-Nutter C., Pittman D. D., Carrier Y., Goodwin D. G., Shields K. M., Lambert A.-J., Schelling S. H., Medley Q. G., Ma H.-L., Collins M., Dunussi-Joannopoulos K., Fouser L. A., IL-22 Induces an Acute-Phase Response, 10.4049/jimmunol.0904091
  28. Zheng Yan, Danilenko Dimitry M., Valdez Patricia, Kasman Ian, Eastham-Anderson Jeffrey, Wu Jianfeng, Ouyang Wenjun, Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis, 10.1038/nature05505
  29. Zenewicz Lauren A., Yancopoulos George D., Valenzuela David M., Murphy Andrew J., Karow Margaret, Flavell Richard A., Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation, 10.1016/j.immuni.2007.07.023
  30. Hanash Alan M., Dudakov Jarrod A., Hua Guoqiang, O’Connor Margaret H., Young Lauren F., Singer Natalie V., West Mallory L., Jenq Robert R., Holland Amanda M., Kappel Lucy W., Ghosh Arnab, Tsai Jennifer J., Rao Uttam K., Yim Nury L., Smith Odette M., Velardi Enrico, Hawryluk Elena B., Murphy George F., Liu Chen, Fouser Lynette A., Kolesnick Richard, Blazar Bruce R., van den Brink Marcel R.M., Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease, 10.1016/j.immuni.2012.05.028
  31. Muñoz Melba, Heimesaat Markus M., Danker Kerstin, Struck Daniela, Lohmann Uwe, Plickert Rita, Bereswill Stefan, Fischer André, Dunay Ildikò Rita, Wolk Kerstin, Loddenkemper Christoph, Krell Hans-Willi, Libert Claude, Lund Leif R., Frey Oliver, Hölscher Christoph, Iwakura Yoichiro, Ghilardi Nico, Ouyang Wenjun, Kamradt Thomas, Sabat Robert, Liesenfeld Oliver, Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17, 10.1084/jem.20090900
  32. Shin H.-J., Baker J., Leveson-Gower D. B., Smith A. T., Sega E. I., Negrin R. S., Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells, 10.1182/blood-2010-10-313684
  33. Taylor P. A., The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality, 10.1182/blood.v99.10.3493
  34. Atarashi K., Tanoue T., Shima T., Imaoka A., Kuwahara T., Momose Y., Cheng G., Yamasaki S., Saito T., Ohba Y., Taniguchi T., Takeda K., Hori S., Ivanov I. I., Umesaki Y., Itoh K., Honda K., Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species, 10.1126/science.1198469
  35. Jenq Robert R., Ubeda Carles, Taur Ying, Menezes Clarissa C., Khanin Raya, Dudakov Jarrod A., Liu Chen, West Mallory L., Singer Natalie V., Equinda Michele J., Gobourne Asia, Lipuma Lauren, Young Lauren F., Smith Odette M., Ghosh Arnab, Hanash Alan M., Goldberg Jenna D., Aoyama Kazutoshi, Blazar Bruce R., Pamer Eric G., R.M. van den Brink Marcel, Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation, 10.1084/jem.20112408
  36. Eriguchi Y., Takashima S., Oka H., Shimoji S., Nakamura K., Uryu H., Shimoda S., Iwasaki H., Shimono N., Ayabe T., Akashi K., Teshima T., Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of  -defensins, 10.1182/blood-2011-12-401166
  37. Ke Y., Sun D., Jiang G., Kaplan H. J., Shao H., IL-22-Induced Regulatory CD11b+ APCs Suppress Experimental Autoimmune Uveitis, 10.4049/jimmunol.1100482
  38. Teshima Takanori, Ordemann Rainer, Reddy Pavan, Gagin Svetlana, Liu Chen, Cooke Kenneth R., Ferrara James L. M., Acute graft-versus-host disease does not require alloantigen expression on host epithelium, 10.1038/nm0602-575
  39. Koyama Motoko, Kuns Rachel D, Olver Stuart D, Raffelt Neil C, Wilson Yana A, Don Alistair L J, Lineburg Katie E, Cheong Melody, Robb Renee J, Markey Kate A, Varelias Antiopi, Malissen Bernard, Hämmerling Günter J, Clouston Andrew D, Engwerda Christian R, Bhat Purnima, MacDonald Kelli P A, Hill Geoffrey R, Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease, 10.1038/nm.2597
  40. Toubai T., Tawara I., Sun Y., Liu C., Nieves E., Evers R., Friedman T., Korngold R., Reddy P., Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells, 10.1182/blood-2011-10-384057
  41. Wolk Kerstin, Haugen Harald S., Xu Wenfeng, Witte Ellen, Waggie Kim, Anderson Monica, vom Baur Elmar, Witte Katrin, Warszawska Katarzyna, Philipp Sandra, Johnson-Leger Caroline, Volk Hans-Dieter, Sterry Wolfram, Sabat Robert, IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not, 10.1007/s00109-009-0457-0
  42. Ferrara J. L. M., Harris A. C., Greenson J. K., Braun T. M., Holler E., Teshima T., Levine J. E., Choi S. W. J., Huber E., Landfried K., Akashi K., Vander Lugt M., Reddy P., Chin A., Zhang Q., Hanash S., Paczesny S., Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease, 10.1182/blood-2011-08-375006
  43. Paczesny S., Braun T. M., Levine J. E., Hogan J., Crawford J., Coffing B., Olsen S., Choi S. W., Wang H., Faca V., Pitteri S., Zhang Q., Chin A., Kitko C., Mineishi S., Yanik G., Peres E., Hanauer D., Wang Y., Reddy P., Hanash S., Ferrara J. L. M., Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin, 10.1126/scitranslmed.3000406
  44. Van Belle A. B., de Heusch M., Lemaire M. M., Hendrickx E., Warnier G., Dunussi-Joannopoulos K., Fouser L. A., Renauld J.-C., Dumoutier L., IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice, 10.4049/jimmunol.1102224
  45. Dudakov J. A., Hanash A. M., Jenq R. R., Young L. F., Ghosh A., Singer N. V., West M. L., Smith O. M., Holland A. M., Tsai J. J., Boyd R. L., van den Brink M. R. M., Interleukin-22 Drives Endogenous Thymic Regeneration in Mice, 10.1126/science.1218004