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The role of adjuvant hormonal treatment after surgery for localized high-risk prostate cancer: results of a matched multiinstitutional analysis.

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Schubert, Maria Joniau, Steven Gontero, Paolo Kneitz, Susanne Scholz, Claus-Jürgen Tombal, Bertrand [UCL] Van Cangh, Paul [UCL] Spahn, Martin

Introduction. To assess the role of adjuvant androgen deprivation therapy (ADT) in high-risk prostate cancer patients (PCa) after surgery. Materials and Methods. The analysis case matched 172 high-risk PCa patients with positive section margins or non-organ confined disease and negative lymph nodes to receive adjuvant ADT (group 1, n = 86) or no adjuvant ADT (group 2, n = 86). Results. Only 11.6% of the patients died, 2.3% PCa related. Estimated 5-10-year clinical progression-free survival was 96.9% (94.3%) for group 1 and 73.7% (67.0%) for group 2, respectively. Subgroup analysis identified men with T2/T3a tumors at low-risk and T3b margins positive disease at higher risk for progression. Conclusion. Patients with T2/T3a tumors are at low-risk for metastatic disease and cancer-related death and do not need adjuvant ADT. We identified men with T3b margin positive disease at highest risk for clinical progression. These patients benefit from immediate adjuvant ADT.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Advances in Urology" - Vol. 2012, p. 612707 (2012)
Peer reviewed yes
Publisher Hindawi Publishing Corporation ((United States) New York)
issn 1687-6369
e-issn 1687-6377
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'urologie
Links
  1. Carver Brett S., Bianco Fernando J., Scardino Peter T., Eastham James A., Long-Term Outcome Following Radical Prostatectomy in Men With Clinical Stage T3 Prostate Cancer, 10.1016/j.juro.2006.03.093
  2. Petrovich Z., Lieskovsky G., Stein J.P., Huberman M., Skinner D.G., Comparison of surgery alone with surgery and adjuvant radiotherapy for pT3N0 prostate cancer : SURGERY VS SURGERY + RADIOTHERAPY IN pT3N0 PROSTATE CANCER, 10.1046/j.1464-410x.2002.02698.x
  3. ROEHL KIMBERLY A., HAN MISOP, RAMOS CHRISTIAN G., ANTENOR JO ANN V., CATALONA WILLIAM J., CANCER PROGRESSION AND SURVIVAL RATES FOLLOWING ANATOMICAL RADICAL RETROPUBIC PROSTATECTOMY IN 3,478 CONSECUTIVE PATIENTS: LONG-TERM RESULTS, 10.1097/01.ju.0000134888.22332.bb
  4. Nguyen Carvell T., Reuther Alwyn M., Stephenson Andrew J., Klein Eric A., Jones J. Stephen, The Specific Definition of High Risk Prostate Cancer Has Minimal Impact on Biochemical Relapse-Free Survival, 10.1016/j.juro.2008.09.027
  5. Yossepowitch Ofer, Eggener Scott E., Bianco Fernando J., Carver Brett S., Serio Angel, Scardino Peter T., Eastham James A., Radical Prostatectomy for Clinically Localized, High Risk Prostate Cancer: Critical Analysis of Risk Assessment Methods, 10.1016/j.juro.2007.03.105
  6. Pilepich M V, Caplan R, Byhardt R W, Lawton C A, Gallagher M J, Mesic J B, Hanks G E, Coughlin C T, Porter A, Shipley W U, Grignon D, Phase III trial of androgen suppression using goserelin in unfavorable-prognosis carcinoma of the prostate treated with definitive radiotherapy: report of Radiation Therapy Oncology Group Protocol 85-31., 10.1200/jco.1997.15.3.1013
  7. Roach Mack, Bae Kyounghwa, Speight Joycelyn, Wolkov Harvey B., Rubin Phillip, Lee R. Jeffrey, Lawton Colleen, Valicenti Richard, Grignon David, Pilepich Miljenko V., Short-Term Neoadjuvant Androgen Deprivation Therapy and External-Beam Radiotherapy for Locally Advanced Prostate Cancer: Long-Term Results of RTOG 8610, 10.1200/jco.2007.13.9881
  8. Messing Edward M, Manola Judith, Yao Jorge, Kiernan Maureen, Crawford David, Wilding George, di'SantAgnese P Anthony, Trump Donald, Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy, 10.1016/s1470-2045(06)70700-8
  9. ZINCKE HORST, LAU WEBER, BERGSTRALH ERIK, BLUTE MICHAEL L., ROLE OF EARLY ADJUVANT HORMONAL THERAPY AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCER, 10.1016/s0022-5347(05)65536-x
  10. Spahn Martin, Weiss Christel, Bader Pia, Ströbel Philipp, Gerharz Elmar W., Kneitz Burkard, Frohneberg Detlef, Long-Term Outcome of Patients with High-Risk Prostate Cancer following Radical Prostatectomy and Stage-Dependent Adjuvant Androgen Deprivation, 10.1159/000277593
  11. Thompson Ian M., Tangen Catherine M., Paradelo Jorge, Lucia M. Scott, Miller Gary, Troyer Dean, Messing Edward, Forman Jeffrey, Chin Joseph, Swanson Gregory, Canby-Hagino Edith, Crawford E. David, Adjuvant Radiotherapy for Pathological T3N0M0 Prostate Cancer Significantly Reduces Risk of Metastases and Improves Survival: Long-Term Followup of a Randomized Clinical Trial, 10.1016/j.juro.2008.11.032
  12. Heidenreich Axel, Bellmunt Joaquim, Bolla Michel, Joniau Steven, Mason Malcolm, Matveev Vsevolod, Mottet Nicolas, Schmid Hans-Peter, van der Kwast Theo, Wiegel Thomas, Zattoni Filliberto, EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Treatment of Clinically Localised Disease, 10.1016/j.eururo.2010.10.039
  13. Vis André N., Schröder Fritz H., van der Kwast Theodorus H., The Actual Value of the Surgical Margin Status as a Predictor of Disease Progression in Men with Early Prostate Cancer, 10.1016/j.eururo.2005.11.030
  14. Dorff Tanya B., Flaig Thomas W., Tangen Catherine M., Hussain Maha H.A., Swanson Gregory P., Wood David P., Sakr Wael A., Dawson Nancy A., Haas Naomi B., Crawford E. David, Vogelzang Nicholas J., Thompson Ian M., Glode L. Michael, Adjuvant Androgen Deprivation for High-Risk Prostate Cancer After Radical Prostatectomy: SWOG S9921 Study, 10.1200/jco.2010.32.2776
  15. Spahn Martin, Joniau Steven, Gontero Paolo, Fieuws Steffen, Marchioro Giansilvio, Tombal Bertrand, Kneitz Burkhard, Hsu Chao-Yu, Van Der Eeckt Katie, Bader Pia, Frohneberg Detlef, Tizzani Alessandro, Van Poppel Hein, Outcome Predictors of Radical Prostatectomy in Patients With Prostate-Specific Antigen Greater Than 20 ng/ml: A European Multi-Institutional Study of 712 Patients, 10.1016/j.eururo.2010.03.001
  16. Hsu Chao-Yu, Joniau Steven, Oyen Raymond, Roskams Tania, Van Poppel Hein, Outcome of Surgery for Clinical Unilateral T3a Prostate Cancer: A Single-Institution Experience, 10.1016/j.eururo.2006.05.024
  17. Bolla Michel, Collette Laurence, Blank Léo, Warde Padraig, Dubois Jean Bernard, Mirimanoff René-Olivier, Storme Guy, Bernier Jacques, Kuten Abraham, Sternberg Cora, Mattelaer Johan, Torecilla José Lopez, Pfeffer J Rafael, Cutajar Carmel Lino, Zurlo Alfredo, Pierart Marianne, Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial, 10.1016/s0140-6736(02)09408-4
  18. Collette Laurence, van Poppel Hein, Bolla Michel, van Cangh Paul, Vekemans Kris, Da Pozzo Luigi, de Reijke Theo M., Verbaeys Antony, Bosset Jean-François, Piérart Marianne, Patients at high risk of progression after radical prostatectomy: Do they all benefit from immediate post-operative irradiation? (EORTC trial 22911), 10.1016/j.ejca.2005.06.024
  19. Van Poppel Hendrik, Cardiovascular risk during hormonal treatment in patients with prostate cancer, 10.2147/cmr.s16893
  20. Freedland Stephen J., Humphreys Elizabeth B., Mangold Leslie A., Eisenberger Mario, Dorey Frederick J., Walsh Patrick C., Partin Alan W., Risk of Prostate Cancer–Specific Mortality Following Biochemical Recurrence After Radical Prostatectomy, 10.1001/jama.294.4.433
  21. Antonarakis Emmanuel S., Chen Yongmei, Elsamanoudi Sally I., Brassell Stephen A., Da Rocha Mario V., Eisenberger Mario A., McLeod David G., Long-term overall survival and metastasis-free survival for men with prostate-specific antigen-recurrent prostate cancer after prostatectomy: analysis of the Center for Prostate Disease Research National Database : DETERMINANTS OF SURVIVAL IN PSA-RECURRENT PROSTATE CANCER AFTER PROSTATECTOMY, 10.1111/j.1464-410x.2010.09878.x
  22. Siddiqui Sameer A., Boorjian Stephen A., Inman Brant, Bagniewski Stephanie, Bergstralh Eric J., Blute Michael L., Timing of Androgen Deprivation Therapy and its Impact on Survival After Radical Prostatectomy: A Matched Cohort Study, 10.1016/j.juro.2008.01.022
  23. Spahn Martin, Kneitz Susanne, Scholz Claus-Jürgen, Nico Stenger, Rüdiger Thomas, Ströbel Philipp, Riedmiller Hubertus, Kneitz Burkhard, Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence, 10.1002/ijc.24715
Bibliographic reference Schubert, Maria ; Joniau, Steven ; Gontero, Paolo ; Kneitz, Susanne ; Scholz, Claus-Jürgen ; et. al. The role of adjuvant hormonal treatment after surgery for localized high-risk prostate cancer: results of a matched multiinstitutional analysis.. In: Advances in Urology, Vol. 2012, p. 612707 (2012)
Permanent URL http://hdl.handle.net/2078.1/126184