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The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude

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Lechner-Scott, J Spencer, B de Malmanche, T Attia, J Fitzgerald, M Van Pesch, Vincent [UCL] MSBase study group

Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) statusfor the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power. Methods: In order to further investigate variation of OCB positivity in patients with MS, we utilized MSBase, a longitudinal, Web-based collaborative MS outcomes registry following clinical cohorts in several continents and latitudes. We also assessed whether OCB positivity affects long-term disability outcome. Results: A total of 13,242 patient records were obtained from 37 MS specialist centres in 19 different countries. OCB status was documented in 4481 (34%) patients and 80% of these were OCB positive. The presence of OCB was associated with degree of latitude (p = 0.02). Furthermore, the outcome of patients negative for CSF-specific OCB was significantly better in comparison to the OCB positive patients, as assessed by Expanded Disability Status Scale change (p < 0.001). Conclusions: The results of this study indicate that latitude could explain some of the inconsistencies in OCB status reported in different populations. The study confirms that OCB positivity in MS is associated with a worse long-term prognosis

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Multiple Sclerosis : clinical and laboratory research" - Vol. 18, no. 7, p. 974-982 (2012)
Peer reviewed yes
Publisher SAGE Publications ((United Kingdom) London)
issn 1352-4585
e-issn 1477-0970
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - (SLuc) Service de neurologie
MESH Subject Adult ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Male ; Multiple Sclerosis ; Oligoclonal Bands ; Registries
Links
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Bibliographic reference Lechner-Scott, J ; Spencer, B ; de Malmanche, T ; Attia, J ; Fitzgerald, M ; et. al. The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude. In: Multiple Sclerosis : clinical and laboratory research, Vol. 18, no. 7, p. 974-982 (2012)
Permanent URL http://hdl.handle.net/2078.1/124780