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Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis.

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Huart, Caroline [UCL] Eloy, Philippe [UCL] Collet, Stéphanie [Mont-Godinne] Rombaux, Philippe [UCL]

Atrophic rhinitis (AR) is a chronic inflammation of the nose characterized by an atrophy of the nasal mucosa. This is typically associated with an impaired sense of smell and a subjective sensation of poor nasal breathing. The aim of this study is to assess chemosensory function in patients suffering from AR using psychophysical testings and event-related potentials (ERP) responses. A cohort of nine patients was extensively studied. Eight out of nine had secondary AR sequela of a bilateral total inferior turbinectomy whereas one patient had a primary AR. All the patients had a clinical evaluation using Sniffin' Sticks test and a retro-olfaction test and an electrophysiological evaluation based upon ERPs obtained after both olfactory and trigeminal stimuli. All the patients complained of a poor nasal breathing and presented a distortion of the chemosensory function. Actually, the orthonasal psychophysical testing showed that four patients out of nine had anosmia, three out of nine had hyposmia and two out of nine were normosmic. All the patients demonstrated retro-olfaction scores inferior to the normal values. The chemosensory ERP showed that seven patients had no olfactory response whereas six had no trigeminal response. Four patients had neither olfactory nor trigeminal ERP response. In conclusion, this study demonstrates that most patients with AR secondary to a total bilateral inferior turbinectomy have a reduction of the chemosensory function measured objectively by psychophysical testings and ERP [corrected].

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "European Archives of Oto-Rhino-Laryngology" - Vol. 269, no. 1, p. 135-141 (2012)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0937-4477
e-issn 1434-4726
Publication status Publié
Affiliations UCL - (SLuc) Service d'oto-rhino-laryngologie
UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Service d'oto-rhino-laryngologie
MESH Subject Adult ; Olfactory Pathways ; Pulmonary Ventilation ; Rhinitis, Atrophic ; Sensory Thresholds ; Smell ; Trigeminal Nerve ; Evoked Potentials ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nose ; Olfaction Disorders
Links
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Bibliographic reference Huart, Caroline ; Eloy, Philippe ; Collet, Stéphanie ; Rombaux, Philippe. Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis.. In: European Archives of Oto-Rhino-Laryngology, Vol. 269, no. 1, p. 135-141 (2012)
Permanent URL http://hdl.handle.net/2078.1/120563