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Increase in the survival time of mice exposed to ionizing radiation by a new class of free radical scavengers.

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Buc Calderon, Pedro [UCL] Roberfroid, Marcel [UCL]

N-acyl dehydroalanines react with and scavenge mainly superoxide radical (O-2.) and hydroxyl radical (HO.). The ortho-methoxyphenylacetyl dehydroalanine derivative, indexed as AD-20, protects mice against damage resulting from total body X-irradiation, as measured by the increase in their survival time. AD-20 increases the LD50 at 30 days from 6.1 to 7.3 Gy in animals exposed to a wide range of X-rays (6 to 10 Gy). The dose reduction factor (D R F) of AD-20 is 1.20. We postulate that such radioprotective effect may result from its free radical scavenging activity.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès restreint
Publication date 1990
Journal information "Experientia" - Vol. 46, no. 7, p. 708-10 (1990)
issn 0014-4754
Publication status Publié
Affiliation UCL
MESH Subject Alanine - analogs & derivatives - pharmacology ; Animals ; Dose-Response Relationship, Radiation ; Female ; Free Radicals ; Mice ; Radiation Injuries, Experimental - drug therapy ; Radiation-Protective Agents ; Superoxides ; Survival Analysis ; X-Rays
Links
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Bibliographic reference Buc Calderon, Pedro ; Roberfroid, Marcel. Increase in the survival time of mice exposed to ionizing radiation by a new class of free radical scavengers.. In: Experientia, Vol. 46, no. 7, p. 708-10 (1990)
Permanent URL http://hdl.handle.net/2078.1/11483