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Determination of the maturity and functionality of tumor vasculature by MRI: correlation between BOLD-MRI and DCE-MRI using P792 in experimental fibrosarcoma tumors.

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Baudelet, Christine [UCL] Cron, Gregory O. [UCL] Gallez, Bernard [UCL]

Using hypercapnia and carbogen as functional markers of vessel maturation and function, we compared blood oxygen level-dependent (BOLD) contrast with standard dynamic contrast-enhanced (DCE)-MRI quantitative parameters in murine fibrosarcoma. Our results show that there was no correlation between vessel maturity and contrast-agent uptake rate (K(in) (Trans)) or contrast agent efflux rate (k(ep)). In addition, DCE-MRI provided higher estimates of the fraction of functional tumor compared to BOLD-MRI. The two putative markers of regional vascular density, i.e., the magnitude of BOLD signal change during carbogen challenge (VF) and the fractional plasma volume found by DCE-MRI (V(p)), were only weakly correlated (r(2) = 0.02-0.14). Furthermore, VF showed no correlation with K(in) (Trans). A positive correlation was observed (r(2) = 0.75) between mean tumor VF and k(ep), but only when averaged over the whole tumor (which includes tumor regions completely unperfused by the gadolinium (Gd) contrast agent). This would merely reveal a relationship between perfusion status and the capacity to respond to carbogen breathing. In conclusion, characterizations of tumor microvasculature imaging using BOLD-MRI and DCE-MRI appear to be largely complementary, given the weak correlations between their corresponding derived parameters.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2006
Journal information "Magnetic Resonance in Medicine" - Vol. 56, no. 5, p. 1041-1049 (2006)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 0740-3194
e-issn 1522-2594
Publication status Publié
Affiliations UCL - MD/FARM - Ecole de pharmacie
UCL - (SLuc) Service de médecine nucléaire
MESH Subject Animals ; Cell Line, Tumor ; Contrast Media ; Fibrosarcoma - blood supply - diagnosis - metabolism ; Heterocyclic Compounds - diagnostic use ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; Mice ; Mice, Inbred C3H ; Neovascularization, Pathologic - diagnosis - metabolism ; Organometallic Compounds - diagnostic use ; Oxygen - metabolism ; Reproducibility of Results ; Sensitivity and Specificity ; Statistics as Topic
Keywords Tumor ; DCE-MRI ; BOLD-MRI ; Carbogen ; Vessel maturation ; Vessel permeability
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Bibliographic reference Baudelet, Christine ; Cron, Gregory O. ; Gallez, Bernard. Determination of the maturity and functionality of tumor vasculature by MRI: correlation between BOLD-MRI and DCE-MRI using P792 in experimental fibrosarcoma tumors.. In: Magnetic Resonance in Medicine, Vol. 56, no. 5, p. 1041-1049 (2006)
Permanent URL http://hdl.handle.net/2078.1/10711