User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Will isomalto-oligosaccharides, a well-established functional food in Asia, break through the European and American market? : The status of knowledge on these prebiotics.

Primary tabs

Goffin, Dorothee Delzenne, Nathalie M. [UCL] Blecker, Christophe Hanon, Emilien Deroanne, Claude Paquot, Michel

This critical review article presents the current state of knowledge on isomalto-oligosaccharides, some well known functional oligosaccharides in Asia, to evaluate their potential as emergent prebiotics in the American and European functional food market. It includes first a unique inventory of the different families of compounds which have been considered as IMOs and their specific structure. A description has been given of the different production methods including the involved enzymes and their specific activities, the substrates, and the types of IMOs produced. Considering the structural complexity of IMO products, specific characterization methods are described, as well as purification methods which enable the body to get rid of digestible oligosaccharides. Finally, an extensive review of their techno-functional and nutritional properties enables placing IMOs inside the growing prebiotic market. This review is of particular interest considering that IMO commercialization in America and Europe is a topical subject due to the recent submission by Bioneutra Inc. (Canada) of a novel food file to the UK Food Standards Agency, as well as several patents for IMO production.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Critical Reviews in Food Science and Nutrition" - Vol. 51, no. 5, p. 394-409 (2011)
Peer reviewed yes
Publisher Taylor & Francis Inc. ((United States) Philadelphia)
issn 1040-8398
e-issn 1549-7852
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
MESH Subject Americas ; Animals ; Oligosaccharides - chemistry, pharmacology ; Prebiotics ; Anticarcinogenic Agents - pharmacology ; Asia ; Canada ; Europe ; Functional Food ; Health Knowledge, Attitudes, Practice ; Humans ; Immunologic Factors - pharmacology
Keywords Isomalto-oligosaccharides ; Gluco-oligosaccharides ; Functional food ; Prebiotics ; Transglucosylation
Links
  1. Ammeraal Robert N., Delgado Gregory A., Tenbarge Francis L., Friedman Robert B., High-performance anion-exchange chromatography with pulsed amperometric detection of linear and branched glucose oligosaccharides, 10.1016/0008-6215(91)84017-9
  2. Arai S., Global view on functional foods: Asian perspectives, 10.1079/bjn2002678
  3. Argüello-Morales M, Sequence analysis of the gene encoding alternansucrase, a sucrose glucosyltransferase from Leuconostoc mesenteroides NRRL B-1355, 10.1016/s0378-1097(99)00572-8
  4. Barker S. A., Carrington T. R., 721. Studies of Aspergillus niger. Part II. Transglycosidation by Aspergillus niger , 10.1039/jr9530003588
  5. Benson Colm P., Kelly Catherine T., Fogarty William M., Production and quantification of transglucosidase from Aspergillus niger, 10.1002/jctb.5030320715
  6. Berensmeier S, Buchholz K, Separation of isomaltose from high sugar concentrated enzyme reaction mixture by dealuminated β-zeolite, 10.1016/j.seppur.2003.10.012
  7. Berry Joffre M., Dutton Guy G.S., Synthesis of isomaltose and other α-D-glucopyranosides, 10.1016/s0008-6215(00)82368-x
  8. Binder Thomas P., Côté Gregory L., Robyt John F., Disproportionation reactions catalyzed by Leuconostoc and Streptococcus glucansucrases, 10.1016/0008-6215(83)88463-8
  9. Boucher J., Daviaud D., Siméon-Remaud M., Carpéné C., Saulnier-Blache J. S., Monsan P., Valet P., Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in high fat diet fed mice, 10.1007/bf03179912
  10. Bouhnik Y., Am. J Clin Nutr., 80, 1658 (2004)
  11. Cai Yaqi, Liu Jingshen, Shi Yali, Liang Lina, Mou Shifen, Determination of several sugars in serum by high-performance anion-exchange chromatography with pulsed amperometric detection, 10.1016/j.chroma.2004.11.100
  12. Cataldi T. R. I., Campa C., De Benedetto G. E., Carbohydrate analysis by high-performance anion-exchange chromatography with pulsed amperometric detection: The potential is still growing, 10.1007/s002160000588
  13. CHAEN HIROTO, NISHIMOTO TOMOYUKI, NAKADA TETSUYA, FUKUDA SHIGEHARU, KURIMOTO MASASHI, TSUJISAKA YOSHIO, Enzymatic Synthesis of Kojioligosaccharides Using Kojibiose Phosphorylase, 10.1263/jbb.92.177
  14. Charcosset Catherine, Membrane processes in biotechnology: An overview, 10.1016/j.biotechadv.2006.03.002
  15. Chen Hsiao-Ling, Lu Yu-Ho, Lin Jiun-Jr, Ko Lie-Yon, Effects of Isomalto-Oligosaccharides on Bowel Functions and Indicators of Nutritional Status in Constipated Elderly Men, 10.1080/07315724.2001.10719013
  16. Chiang B L, Sheih Y H, Wang L H, Liao C K, Gill H S, Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses, 10.1038/sj.ejcn.1601093
  17. CHIBA Seiya, SAEKI Takeshi, SHIMOMURA Tokuji, Substrate Specificity of Saccharomyces logos α-Glucosidase, 10.1271/bbb1961.37.1831
  18. Chiba S., Handbook of Amylases and Related Enzymes, 104 (1988)
  19. Chiba Seiya, Molecular Mechanism inα-Glucosidase and Glucoamylase, 10.1271/bbb.61.1233
  20. Lee Ching-Ching, Wang Hsueh-Fang, Lin Sheng-Dun, Effect of Isomaltooligosaccharide Syrup on Quality Characteristics of Sponge Cake, 10.1094/cchem-85-4-0515
  21. Chung C. H., A potential nutraceutical from leuconostoc mesenteroïde B-742 (ATCC 13146); production and properties (2002)
  22. Chung, C.H. and Day, D. F. 2004. Efficacy ofLeuconostoc mesenteroides(ATCC 13146)
  23. Chung C. H., Day D. F., Efficacy of Leuconostoc mesenteroides (ATCC 13146) isomaltooligosaccharides as a poultry prebiotic, 10.1093/ps/83.8.1302
  24. Conway P. L., Scandinavian J Nutr., 45, 13 (2001)
  25. Côté Gregory L., Robyt John F., Isolation and partial characterization of an extracellular glucansucrase from Leuconostoc mesenteroides NRRL B-1355 that synthesizes an alternating (1→6), (1→3)-α-d-glucan, 10.1016/s0008-6215(00)80795-8
  26. Cote Gregory L, Tao Bernard Y, Oligosaccharide synthesis by enzymatic transglycosylation, 10.1007/bf01050377
  27. Côté G. L., Oligosaccharides in Food and Agriculture, 849, 77 (2003)
  28. Côté Gregory L., Sheng Suzie, Penta-, hexa-, and heptasaccharide acceptor products of alternansucrase, 10.1016/j.carres.2006.04.044
  29. Playne R. Crittenden, M., Purification of food-grade oligosaccharides using immobilised cells of Zymomonas mobilis, 10.1007/s00253-001-0886-3
  30. Crout David HG, Vic Gabin, Glycosidases and glycosyl transferases in glycoside and oligosaccharide synthesis, 10.1016/s1367-5931(98)80041-0
  31. Delzenne Nathalie M., Williams Christine M., Prebiotics and lipid metabolism : , 10.1097/00041433-200202000-00009
  32. Delzenne N. M., Oligosaccharides: state of the art, 10.1079/pns2002225
  33. Demuth Kristin, Jördening Hans-Joachim, Buchholz Klaus, Oligosaccharide synthesis by dextransucrase: new unconventional acceptors, 10.1016/s0008-6215(02)00272-0
  34. Djouzi Z., Andrieux C., Pelenc V., Somarriba S., Popot F., Paul F., Monsan P., Szylit O., Degradation and fermentation of α-gluco-oligosaccharides by bacterial strains from human colon:in vitroandin vivostudies in gnotobiotic rats, 10.1111/j.1365-2672.1995.tb00924.x
  35. Djouzi Zakia, Andlueux Claude, Compared effects of three oligosaccharides on metabolism of intestinal microflora in rats inoculated with a human faecal flora, 10.1079/bjn19970149
  36. Dols Marguerite, Remaud Simeon Magali, Willemot René-Marc, Vignon Michel R., Monsan Pierre F., Structural characterization of the maltose acceptor-products synthesized by Leuconostoc mesenteroides NRRL B-1299 dextransucrase, 10.1016/s0008-6215(97)10063-5
  37. Dols-Lafargue Marguerite, Willemot Ren�-Marc, Monsan Pierre F., Remaud-Simeon Magali, Factors affecting ?,-1,2 glucooligosaccharide synthesis byLeuconostoc mesenteroides NRRL B-1299 dextransucrase, 10.1002/bit.1141
  38. Doudoroff M., J Biol. Chem., 168, 725 (1947)
  39. Douglas Linda C., Sanders Mary E., Probiotics and Prebiotics in Dietetics Practice, 10.1016/j.jada.2007.12.009
  40. Duan Kow Jen, Sheu Dey Chyi, Lin Ming Tse, Hsueh Hsiao Chiang, Reaction mechanism of isomaltooligosaccharides synthesis by ?-glucosidase fromAspergillus carbonarious, 10.1007/bf01020842
  41. DUAN KOW-JEN, SHEU DEY-CHYI, LIN CHI-TSAI, Transglucosylation of a Fungal ?-Glucosidase. The Enzyme Properties and Correlation of Isomaltooligosaccharide Production, 10.1111/j.1749-6632.1995.tb19974.x
  42. Faijes Magda, Planas Antoni, In vitro synthesis of artificial polysaccharides by glycosidases and glycosynthases, 10.1016/j.carres.2007.06.015
  43. Fan J.Q., Kondo A., Kato I., Lee Y.C., High-Performance Liquid Chromatography of Glycopeptides and Oligosaccharides on Graphitized Carbon Columns, 10.1006/abio.1994.1261
  44. Fedorak Richard N., Madsen Karen L., Probiotics and prebiotics in gastrointestinal disorders : , 10.1097/00001574-200403000-00017
  45. Fernández-Arrojo Lucía, Marín Dolores, Gómez De Segura Aranzazu, Linde Dolores, Alcalde Miguel, Gutiérrez-Alonso Patricia, Ghazi Iraj, Plou Francisco J., Fernández-Lobato María, Ballesteros Antonio, Transformation of maltose into prebiotic isomaltooligosaccharides by a novel α-glucosidase from Xantophyllomyces dendrorhous, 10.1016/j.procbio.2007.08.007
  46. Flickinger E. A., J Nutr., 130, 1267 (2000)
  47. Fooks Laura J., Fuller Roy, Gibson Glenn R., Prebiotics, probiotics and human gut microbiology, 10.1016/s0958-6946(99)00044-8
  48. Frandsen Torben P., Svensson Birte, 10.1023/a:1005925819741
  49. Gibson G. R., J Nutr., 125, 1401 (1995)
  50. Gibson Glenn R., Probert Hollie M., Loo Jan Van, Rastall Robert A., Roberfroid Marcel B., Dietary modulation of the human colonic microbiota: updating the concept of prebiotics, 10.1079/nrr200479
  51. Goffin Dorothée, Robert Christelle, Wathelet Bernard, Blecker Christophe, Malmendier Yves, Paquot Michel, A Step-Forward Method of Quantitative Analysis of Enzymatically Produced Isomaltooligosaccharide Preparations by AEC-PAD, 10.1365/s10337-008-0875-0
  52. Goffin, D., Paquot, M., Blecker, C. and Robert, C. Process for the production of a composition, the composition and the use there-of as food additive. European Patent No. 09150869.7, submitted in january 2009
  53. A Systematic NMR Determination of α-D-Glucooligosaccharides, Effect of Linkage Type, Anomeric Configuration and Combination of Different Linkages Type on13C Chemical Shifts for the Determination of Unknown Isomaltooligosaccharides, 10.5012/bkcs.2009.30.11.2535
  54. Goffin, D., Karlsson, N.G., Paquot, M. and Savage, A. V. 2009. Structural analysis of α-gluco-oligosaccharides by negative ion, graphitized carbon micro-liquid chromatography/electrospray ionization mass spectrometry, as a tool to identify unknown Isomalto-oligosaccharides (Under revision).
  55. Goffin D., BASE (2010)
  56. Goulas Athanasios K, Grandison Alistair S, Rastall Robert A, Fractionation of oligosaccharides by nanofiltration, 10.1002/jsfa.1335
  57. Goulas Athanasios K, Fisher Don A, Grimble George K, Grandison Alistair S, Rastall Robert A, Synthesis of isomaltooligosaccharides and oligodextrans by the combined use of dextransucrase and dextranase, 10.1016/j.enzmictec.2004.05.008
  58. Goulas Athanasios K., Cooper Julian M., Grandison Alistair S., Rastall Robert A., Synthesis of isomaltooligosaccharides and oligodextrans in a recycle membrane bioreactor by the combined use of dextransucrase and dextranase, 10.1002/bit.20257
  59. Grandison A. S., Songklanakarin J Sci. Technol., 24, 915 (2002)
  60. Grizard Damien, Barthomeuf Chantal, Non-digestible oligosaccharides used as prebiotic agents: mode of production and beneficial effects on animal and human health, 10.1051/rnd:19990505
  61. Gu Q., J Hyg. Res., 32, 54 (2003)
  62. Guddat Sven, Thevis Mario, Schänzer Wilhelm, Identification and quantification of the plasma volume expander dextran in human urine by liquid chromatography-tandem mass spectrometry of enzymatically derived Isomaltose, 10.1002/bmc.509
  63. Hamada S., J General Microbiol., 116, 51 (1980)
  64. Hamada Shigeyuki, Role of sweeteners in the etiology and prevention of dental caries, 10.1351/pac200274071293
  65. Hasler Clare M., Functional Foods: The Western Perspective, 10.1111/j.1753-4887.1996.tb03810.x
  66. Hasler Clare M., The Changing Face of Functional Foods, 10.1080/07315724.2000.10718972
  67. Hayakawa Kazuichi, Ando Kyoko, Yoshida Natsue, Yamamoto Atsushi, Matsunaga Akinobu, Nishimura Masayuki, Kitaoka Mitsuo, Matsui Keizo, Determination of saccharides in sake by high-performance liquid chromatography with polarized photometric detection, 10.1002/(sici)1099-0801(200004)14:2<72::aid-bmc927>3.0.co;2-s
  68. HINO Keiko, KUROSE Mayumi, SAKURAI Takeo, INOUE Shin-ichiro, OKU Kazuyuki, CHAEN Hiroto, KOHNO Keizo, FUKUDA Shigeharu, Effect of Dietary Cyclic Nigerosylnigerose on Intestinal Immune Functions in Mice, 10.1271/bbb.60215
  69. Holtkamp M., Erhardt F.A., Jördening H.-J., Scholl S., Reaction-integrated separation of isomaltose by ad- and desorption on zeolite, 10.1016/j.cep.2008.11.001
  70. Imai S., Takeuchi K., Shibata K., Yoshikawa S., Kitahata S., Okada S., Araya S., Nisizawa T., Screening of Sugars Inhibitory against Sucrose-dependent Synthesis and Adherence of Insoluble Glucan and Acid Production by Streptococcus mutans, 10.1177/00220345840630110801
  71. Inan Mehmet Sait, Rasoulpour Reza J., Yin Lei, Hubbard Andrea K., Rosenberg Daniel W., Giardina Charles, The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line, 10.1016/s0016-5085(00)70142-9
  72. Jahnel J. B., Ilieva P., Frimmel F. H., HPAE-PAD - a sensitive method for the determination of carbohydrates, 10.1007/s002160050819
  73. Jeanes Allene, Haynes W. C., Wilham C. A., Rankin J. C., Melvin E. H., Austin Marjorie J., Cluskey J. E., Fisher B. E., Tsuchiya H. M., Rist C. E., Characterization and Classification of Dextrans from Ninety-six Strains of Bacteria1b, 10.1021/ja01649a011
  74. Kaneko T., Journal of the Japan Society for Bioscience Biotechnology and Agrochemistry, 66, 1211 (1992)
  75. Kaneko Toshiyuki, Kohmoto Takanobu, Kikuchi Hiroe, Shiota Masao, Iino Hisakazu, Mitsuoka Tomotari, Effects of Isomaltooligosaccharides with Different Degrees of Polymerization on Human Fecal Bifidobactcria, 10.1271/bbb.58.2288
  76. Kaneko Toshiyuki, Yokoyama Aki, Suzuki Masabumi, Digestibility Characteristics of Isomaltooligosaccharides in Comparison with Several Saccharides Using the Rat Jejunum Loop Method, 10.1271/bbb.59.1190
  77. Kaneko Toshiyuki, Matsukubo Takashi, Yatake Tsuneya, Muramatsu Yasuko, Takaesu Yoshinori, Evaluation of Acidogenicity of Commercial Isomaltooligosaccharides Mixture and Its Hydrogenated Derivative by Measurement of pH Response under Human Dental Plaque, 10.1271/bbb.59.372
  78. Kanno T., Denpun Kagaku, 37, 87 (1990)
  79. Kato N., Suyama S., Shirokane M., Kato M., Kobayashi T., Tsukagoshi N., Novel  -Glucosidase from Aspergillus nidulans with Strong Transglycosylation Activity, 10.1128/aem.68.3.1250-1256.2002
  80. Karlsson Niclas G., Wilson Nicole L., Wirth Hans-J�rgen, Dawes Peter, Joshi Hiren, Packer Nicolle H., Negative ion graphitised carbon nano-liquid chromatography/mass spectrometry increases sensitivity for glycoprotein oligosaccharide analysis, 10.1002/rcm.1626
  81. Khalikova E., Susi P., Korpela T., Microbial Dextran-Hydrolyzing Enzymes: Fundamentals and Applications, 10.1128/mmbr.69.2.306-325.2005
  82. Killey Mary, Dimler R. J., Cluskey J. E., Preparation of Panose by the Action of NRRL B-512 Dextransucrase on a Sucrose-Maltose Mixture2, 10.1021/ja01617a048
  83. Kim A. S., Gast., 134, 694 (2008)
  84. Kim Young-Min, Seo Mi-Young, Kang Hee-Kyoung, Atsuo Kimura, Kim Doman, Construction of a fusion enzyme of dextransucrase and dextranase: Application for one-step synthesis of isomalto-oligosaccharides, 10.1016/j.enzmictec.2008.10.007
  85. KITA Akihiko, MATSUI Hirokazu, SOMOTO Akishige, KIMURA Atsuo, TAKATA Masuhiro, CHIBA Seiya, Substrate Specificity and Subsite Affinities of Crystalline .ALPHA.-Glucosidase from Aspergillus niger., 10.1271/bbb1961.55.2327
  86. Kitahata S., J Biol. Chem., 256, 6017 (1981)
  87. Kitaoka Motomitsu, Robyt John F., Mechanism of the action of Leuconostoc mesenteroides B-512FMC dextransucrase: kinetics of the transfer of d-glucose to maltose and the effects of enzyme and substrate concentrations, 10.1016/s0008-6215(99)00155-x
  88. KOBAYASHI Isao, TOKUDA Masahiro, HASHIMOTO Hiroyuki, KONDA Takashi, NAKANO Hirofumi, KITAHATA Sumio, Purification and Characterization of a New Type of α-Glucosidase fromPaecilomyces lilacinusThat Has Transglucosylation Activity to Produce α-1,3- and α-1,2-Linked…, 10.1271/bbb.67.29
  89. Koepsell H. J., J Biol. Chem., 200, 793 (1953)
  90. Koga Toshihiko, Horikoshi Toshio, Fujiwara Taku, Hamada Shigeyuki, Effects of Panose on Glucan Synthesis and Cellular Adherence byStreptococcus mutans, 10.1111/j.1348-0421.1988.tb01362.x
  91. KOHMOTO Takanobu, FUKUI Fumio, TAKAKU Hajime, MACHIDA Yoshiaki, ARAI Masaaki, MITSUOKA Tomotari, Effect of Isomalto-oligosaccharides on Human Fecal Flora, 10.12938/bifidus1982.7.2_61
  92. KOHMOTO Takanobu, FUKUI Fumio, TAKAKU Hajime, MITSUOKA Tomotari, Dose-response Test of Isomaltooligosaccharides for Increasing Fecal Bifidobacteria., 10.1271/bbb1961.55.2157
  93. Kohmoto Takanobu, Tsuji Keisuke, Kaneko Toshiyuki, Shiota Masao, Fukui Fumio, Takaku Hajime, Nakagawa Yasue, Ichikawa Tomio, Kobayash Syuuhei, Metabolism of13C-Isomaltooligosaccharides in Healthy Men, 10.1271/bbb.56.937
  94. Koizumi Kyoko, Kubota Yoko, Tanimoto Toshiko, Okada Yasuyo, High-performance anion-exchange chromatography of homogeneous d-gluco-oligosaccharides and -polysaccharides (polymerization degree ⩾ 50) with pulsed amperometric detection, 10.1016/s0021-9673(00)94254-7
  95. Koizumi Kyoko, Okada Yasuyo, Fukuda Masako, High-performance liquid chromatography of mono- and oligo-saccharides on a graphitized carbon column, 10.1016/0008-6215(91)84008-3
  96. Koizumi Kyoko, High-performance liquid chromatographic separation of carbohydrates on graphitized carbon columns, 10.1016/0021-9673(94)01274-1
  97. Kolida Sofia, Tuohy K., Gibson Glenn R., The human gut flora in nutrition and approaches for its dietary modulation, 10.1046/j.1467-3010.2000.00050.x
  98. Konishi Yutaka, Shindo Kazutoshi, Production of Nigerose, Nigerosyl Glucose, and Nigerosyl Maltose byAcremoniumsp. S4G13, 10.1271/bbb.61.439
  99. Kubik Celina, Sikora Barbara, Bielecki Stanisław, Immobilization of dextransucrase and its use with soluble dextranase for glucooligosaccharides synthesis, 10.1016/j.enzmictec.2003.11.022
  100. Kuriki Takashi, Tsuda Manabu, Imanaka Tadayuki, Continuous production of panose by immobilized neopullulanase, 10.1016/0922-338x(92)90160-v
  101. Kuriki Takashi, Yanase Michiyo, Takata Hiroki, Imanaka Tadayuki, Okada Shigetaka, Highly branched oligosaccharides produced by the transglycosylation reaction of neopullulanase, 10.1016/0922-338x(93)90005-s
  102. Kuriki T., Appl Environ. Microbiol., 59, 953 (1993)
  103. Kuriki T., Biologia, Bratislava, 60, 13 (2005)
  104. Lamothe J. P., Compositions cosmétiques contenant des glucooligosaccharides (1991)
  105. Lee Shiow-Ling, Chen Wen-Chang, Optimization of medium composition for the production of glucosyltransferase by Aspergillus niger with response surface methodology, 10.1016/s0141-0229(97)00016-1
  106. Improving Effects of Fructooligosaccharide and Isomaltooligosaccharide Contained in Sponge Cakes on the Constipation of Female College Students, 10.3746/jkfn.2003.32.4.621
  107. Li F., Grain compositions containing pre-biotic isomalto-oligosaccharides and methods of making and using same (2004)
  108. Li Jiqiu, Tan Beiping, Mai Kangsen, Dietary probiotic Bacillus OJ and isomaltooligosaccharides influence the intestine microbial populations, immune responses and resistance to white spot syndrome virus in shrimp (Litopenaeus vannamei), 10.1016/j.aquaculture.2009.03.005
  109. Loo Jan Van, Cummings John, Delzenne Nathalie, Englyst Hans, Franck Anne, Hopkins Mark, Kok Nadine, Macfarlane George, Newton Dorothy, Quigley Michael, Roberfroid Marcel, van Vliet Trinette, van den Heuvel Ellen, Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project (DGXII AIRII-CT94-1095), 10.1017/s0007114599000252
  110. Lucas J., European Union-funded research on probiotics, prebiotics and new foods, 10.1016/s1590-8658(02)80175-x
  111. MACFARLANE S., MACFARLANE G. T., CUMMINGS J. H., Review article: prebiotics in the gastrointestinal tract, 10.1111/j.1365-2036.2006.03042.x
  112. Malá Šárka, Dvořáková Hana, Hrabal Richard, Králová Blanka, Towards regioselective synthesis of oligosaccharides by use of α-glucosidases with different substrate specificity, 10.1016/s0008-6215(99)00222-0
  113. Manning Thea Scantlebury, Gibson Glenn R, Prebiotics, 10.1016/j.bpg.2003.10.008
  114. McCleary Barry V., Gibson Trevor S., Sheehan Helen, Casey Ailin, Horgan Liam, O'Flaherty John, Purification, properties, and industrial significance of transglucosidase from Aspergillus niger, 10.1016/0008-6215(89)84030-3
  115. Milner J. A., Am. J Clin Nutr., 71, 1654 (2000)
  116. Minami T., Shoni Shikagaku Zasshi, 27, 1010 (1989)
  117. Mirmira S. R., Schreiber M. A., Guessford S. A., High Performance Ion Chromatographic Analysis of Glucose, Isomaltose, and Maltose in Hydroxyethyl Starch, 10.1080/10826079308019598
  118. Mizubuchi H., J Nutr., 135, 2857 (2005)
  119. Monchois Vincent, Willemot René-Marc, Monsan Pierre, Glucansucrases: mechanism of action and structure–function relationships, 10.1111/j.1574-6976.1999.tb00394.x
  120. Monsan Pierre, Paul François, Enzymatic synthesis of oligosaccharides, 10.1111/j.1574-6976.1995.tb00165.x
  121. Monsan Pierre, Bozonnet Sophie, Albenne Cécile, Joucla Gilles, Willemot René-Marc, Remaud-Siméon Magali, Homopolysaccharides from lactic acid bacteria, 10.1016/s0958-6946(01)00113-3
  122. Mooser G., The Enzymes, 20, 187 (1992)
  123. Mountzouris K.C., Gilmour S.G., Grandison A.S., Rastall R.A., Modeling of oligodextran production in an ultrafiltration stirred-cell membrane reactor, 10.1016/s0141-0229(98)00093-3
  124. Mountzouris K.C., Gilmour S.G., Rastall R.A., Continuous Production of Oligodextrans via Controlled Hydrolysis of Dextran in an Enzyme Membrane Reactor, 10.1111/j.1365-2621.2002.tb08720.x
  125. Moynihan P.J., Update on the nomenclature of carbohydrates and their dental effects, 10.1016/s0300-5712(97)00010-9
  126. Mu X., A method for the removal of monosaccharide in oligosaccharides production (2005)
  127. Mu X., A method to control the distribution of the starch sugars molecular weight in oligosaccharides production (2005)
  128. Mukai K., Watanabe H., Kubota M., Chaen H., Fukuda S., Kurimoto M., Purification, Characterization, and Gene Cloning of a Novel Maltosyltransferase from an Arthrobacter globiformis Strain That Produces an Alternating  -1,4- and  -1,6-Cyclic Tetrasaccharide from Starch, 10.1128/aem.72.2.1065-1071.2006
  129. Murase Hironobu, Yamauchi Ryo, Kato Koji, Kunieda Tsutomu, Terao Junji, Synthesis of a novel vitamin E derivative, 2-(α-d-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, by α-glucosidase-catalyzed transglycosylation, 10.1007/s11745-997-0011-6
  130. MUROSAKI Shinji, MUROYAMA Koutarou, YAMAMOTO Yoshihiro, KUSAKA Hiroaki, LIU Tiei, YOSHIKAI Yasunobu, Immunopotentiating Activity of Nigerooligosaccharides for the T Helper 1-Like Immune Response in Mice, 10.1271/bbb.63.373
  131. Murosaki Shinji, Muroyama Koutarou, Yamamoto Yoshihiro, Liu Tiei, Yoshikai Yasunobu, Nigerooligosaccharides augments natural killer activity of hepatic mononuclear cells in mice, 10.1016/s1567-5769(01)00152-7
  132. Mussatto Solange I., Mancilha Ismael M., Non-digestible oligosaccharides: A review, 10.1016/j.carbpol.2006.12.011
  133. Nakakuki T., Japanese Technology Reviews Vol. 3, No. 2, 204 (1993)
  134. Nakakuki Teruo, Development of Functional Oligosaccharides in Japan, 10.4052/tigg.15.57
  135. Nakakuki Teruo, Present Status and Future Prospects of Functional Oligosaccharide Development in Japan, 10.5458/jag.52.267
  136. Nakanishi Kazuhiro, Matsuno Ryuichi, Torii Kazuyuki, Yamamoto Kazuhiro, Kamikubo Tadashi, Properties of immobilized β-d-galactosidase from Bacillus circulans, 10.1016/0141-0229(83)90044-3
  137. Nakanishi Taisuke, Nomura Satoru, Takeda Yasuhito, An Improved Method for the Quantitative Analysis of Commercial Isomaltooligosaccharide Products Using the Calibration Curve of Standard Reagents, 10.5458/jag.53.215
  138. NISHIMOTO Tomoyuki, AGA Hajime, MUKAI Kazuhisa, HASHIMOTO Takaharu, WATANABE Hikaru, KUBOTA Michio, FUKUDA Shigeharu, KURIMOTO Masashi, TSUJISAKA Yoshio, Purification and Characterization of Glucosyltransferase and Glucanotransferase Involved in the Production of Cyclic Tetrasaccharide inBacillus globisporusC11, 10.1271/bbb.66.1806
  139. Oguma Tetsuya, Tobe Kouichiro, Kobayashi Mikihiko, Purification and properties of a novel enzyme fromBacillusspp. T-3040, which catalyses the conversion of dextran to cyclic isomaltooligosaccharides, 10.1016/0014-5793(94)00418-8
  140. Olano-Martin E., Brit J Nutr., 83, 247 (2000)
  141. Ooshima Takashi, Fujiwara Taku, Takei Tsutomu, Izumitani Akira, Sobue Shizuo, Hamada Shigeyuki, The Caries Inhibitory Effects of GOS-Sugarin vitroand in Rat Experiments, 10.1111/j.1348-0421.1988.tb01474.x
  142. Ouwehand A.C., Curr Opin Microbiol., 16, 212 (2005)
  143. Palframan Richard J., Gibson Glenn R., Rastall Robert A., Effect of pH and Dose on the Growth of Gut Bacteria on Prebiotic Carbohydrates in vitro, 10.1006/anae.2002.0434
  144. Palframan R., Gibson G.R., Rastall R.A., Development of a quantitative tool for the comparison of the prebiotic effect of dietary oligosaccharides, 10.1046/j.1472-765x.2003.01398.x
  145. Pan S. C., Andreasen A. A., Kolachov P., Enzymic Conversion of Maltose into Unfermentable Carbohydrate, 10.1126/science.112.2900.115
  146. Pan Yen-Chung, Lee Wen-Chien, Production of high-purity isomalto-oligosaccharides syrup by the enzymatic conversion of transglucosidase and fermentation of yeast cells, 10.1002/bit.20402
  147. Pastuch G., Pol J Chem., 77, 995 (2003)
  148. Paul F., Oriol E., Auriol D., Monsan P., Acceptor reaction of a highly purified dextransucrase with maltose and oligosaccharides. Application to the synthesis of controlled-molecular-weight dextrans, 10.1016/s0008-6215(00)90063-6
  149. Paul F., Procédé de préparation enzymatique d'oligodextranes utiles dans la fabrication de substituts de sucre, et nouveaux oligodextranes (1992)
  150. Paul F., Method for the production of α-(1,2) oligodextrans using Leuconostoc mesenteroides B-1299 (1992)
  151. Paskach Thomas J., Lieker Heinz-Peter, Reilly Peter J., Thielecke Klaus, High-performance anion-exchange chromatography of sugars and sugar alcohols on quaternary ammonium resins under alkaline conditions, 10.1016/0008-6215(91)84002-v
  152. Pazur John H., French Dexter, THE TRANSGLUCOSIDASE OF ASPERGILLUS ORYZAE1, 10.1021/ja01151a541
  153. Pazur J., J Biol Chem., 196, 265 (1952)
  154. Pazur John H., Cepure Austra, Okada Shigetaka, Forsberg L.Scott, Comparison of the action of glucoamylase and glucosyltransferase on D-glucose, maltose, and malto-oligosaccharides, 10.1016/s0008-6215(00)83415-1
  155. Pazur John H., Tominaga Yoshio, DeBrosse Charles W., Jackman Lloyd M., The synthesis of 1,6-anhydro-β-d-glucopyranose and d-glucosyl oligosaccharides from maltose by a fungal glucosyltransferase, 10.1016/s0008-6215(00)84488-2
  156. Perlné M. I., Acta Pharma Hung., 70, 231 (2000)
  157. Perugino G, Oligosaccharide synthesis by glycosynthases, 10.1016/j.tibtech.2003.10.008
  158. Playne M. J., Bioprocesses and Biotechnology for Functional Foods and Nutraceuticals, 120 (2004)
  159. Plou Francisco J, Martín M Teresa, de Segura Aránzazu Gomez, Alcalde Miguel, Ballesteros Antonio, Glucosyltransferases acting on starch or sucrose for the synthesis of oligosaccharides, 10.1139/v02-104
  160. Plou Francisco J., Segura Aránzazu Gómez de, Ballesteros Antonio, Application of Glycosidases and Transglycosidases in the Synthesis of Oligosaccharides, Industrial Enzymes ISBN:9781402053764 p.141-157, 10.1007/1-4020-5377-0_9
  161. Pratt Vera C., Tappenden Kelly A., McBurney Michael I., Field Catherine J., Short-Chain Fatty Acid-Supplemented Total Parenteral Nutrition Improves Nonspecific Immunity After Intestinal Resection in Rats, 10.1177/0148607196020004264
  162. Rastall Robert A., Maitin Vatsala, Prebiotics and synbiotics: towards the next generation, 10.1016/s0958-1669(02)00365-8
  163. Rastall Robert A., Hotchkiss Arland T., Potential for the Development of Prebiotic Oligosaccharides from Biomass, ACS Symposium Series (2003) ISBN:084123826X p.44-53, 10.1021/bk-2003-0849.ch004
  164. Rastall Robert A., Gibson Glenn R., Gill Harsharnjit S., Guarner Fransisco, Klaenhammer Todd R., Pot Bruno, Reid Gregor, Rowland Ian R., Sanders Mary Ellen, Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications, 10.1016/j.femsec.2005.01.003
  165. REHMAN H., VAHJEN W., KOHL-PARISINI A., IJAZ A., ZENTEK J., Influence of fermentable carbohydrates on the intestinal bacteria and enteropathogens in broilers, 10.1017/s0043933909000006
  166. Remaud-Slmeon M., Lopez-Munguia A., Pelenc V., Paul F., Monsan P., Production and use of glucosyltransferases fromLeuconostoc mesenteroides NRRL B-1299 for the synthesis of oligosaccharides containing α-(1→2) linkages, 10.1007/bf02921648
  167. Remaud-Simeon Magali, Willemot René-Marc, Sarçabal Patricia, Potocki de Montalk Gabrielle, Monsan Pierre, Glucansucrases: molecular engineering and oligosaccharide synthesis, 10.1016/s1381-1177(00)00119-3
  168. Roberfroid M. B., Health Benefits of Non-Digestible Oligosaccharides, Advances in Experimental Medicine and Biology (1997) ISBN:9781461377351 p.211-219, 10.1007/978-1-4615-5967-2_22
  169. Roberfroid Marcel, Slavin Joanne, Nondigestible Oligosaccharides, 10.1080/10408690091189239
  170. Roberfroid M. B., Global view on functional foods: European perspectives, 10.1079/bjn2002677
  171. Roberfroid M., Functional food concept and its application to prebiotics, 10.1016/s1590-8658(02)80176-1
  172. Roberfroid M. B., Handbook of Prebiotics, 40 (2008)
  173. Robyt John F., Walseth Timothy F., The mechanism of acceptor reactions of leuconostoc mesenteroides B-512F dextransucrase, 10.1016/s0008-6215(00)84503-6
  174. Robyt John F., Eklund Steven H., Relative, quantitative effects of acceptors in the reaction of Leuconostoc mesenteroides B-512F dextransucrase, 10.1016/0008-6215(83)84024-5
  175. Robyt John F., Mukerjea Rupendra, Separation and quantitative determination of nanogram quantities of maltodextrins and isomaltodextrins by thin-layer chromatography, 10.1016/0008-6215(94)84285-x
  176. Röper H., Koch H., New Carbohydrate Derivatives from Biotechnical and Chemical Processes, 10.1002/star.19880401203
  177. Ruhaak L. Renee, Deelder André M., Wuhrer Manfred, Oligosaccharide analysis by graphitized carbon liquid chromatography–mass spectrometry, 10.1007/s00216-009-2664-5
  178. Rycroft C.E., Jones M.R., Gibson G.R., Rastall R.A., A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides, 10.1046/j.1365-2672.2001.01446.x
  179. Saarela M, Lähteenmäki L, Crittenden R, Salminen S, Mattila-Sandholm T, Gut bacteria and health foods—the European perspective, 10.1016/s0168-1605(02)00235-0
  180. Santos A., San Mauro M., Díaz D. Marquina, Prebiotics and their long-term influence on the microbial populations of the mouse bowel, 10.1016/j.fm.2005.07.004
  181. Sanz María Luz, Gibson Glenn R., Rastall Robert A., Influence of Disaccharide Structure on Prebiotic Selectivity in Vitro, 10.1021/jf050276w
  182. Sasaki Makoto, Joh Takashi, Koikeda Satoshi, Kataoka Hiromi, Tanida Satoshi, Oshima Tadayuki, Ogasawara Naotaka, Ohara Hirotaka, Nakao Haruhisa, Kamiya Takeshi, A Novel Strategy in Production of Oligosaccharides in Digestive Tract: Prevention of Postprandial Hyperglycemia and Hyperinsulinemia, 10.3164/jcbn.2007027
  183. SAWAI Teruo, NIWA Yasuro, Transisomaltosylation activity of a bacterial isomalto-dextranase., 10.1271/bbb1961.39.1077
  184. Seo Eun-Seong, Nam Seung-Hee, Kang Hee-Kyung, Cho Jae-Yong, Lee Hee-Seon, Ryu Hwa-Won, Kim Doman, Synthesis of thermo- and acid-stable novel oligosaccharides by using dextransucrase with high concentration of sucrose, 10.1016/j.enzmictec.2006.08.017
  185. Smiley Karl L., Slodki Morey E., Boundy Joyce A., Plattner Ronald D., A simplified method for preparing linear isomalto-oligosaccharides, 10.1016/s0008-6215(00)81798-x
  186. Schmidt Finn, Stig Enevoldsen Bent, Comparative studies of malto- and isomalto-oligosaccharides and their corresponding alditols, 10.1016/s0008-6215(00)84480-8
  187. Swennen Katrien, Courtin Christophe M., Delcour Jan A., Non-digestible Oligosaccharides with Prebiotic Properties, 10.1080/10408390500215746
  188. Takaku H., Handbook of Amylases and Related Enzymes: Their Sources, Isolation Methods, Properties and Applications, 215 (1988)
  189. Takata H., J Biol Chem., 267, 18447 (1992)
  190. Tanriseven Aziz, Doğan Şenay, Production of isomalto-oligosaccharides using dextransucrase immobilized in alginate fibres, 10.1016/s0032-9592(01)00319-3
  191. Thitaram S. N., Chung C.- H., Day D. F., Hinton A., Bailey J. S., Siragusa G. R., Isomaltooligosaccharide increases cecal Bifidobacterium population in young broiler chickens, 10.1093/ps/84.7.998
  192. Tomomatsu H., Food Technol., 48, 61 (1994)
  193. Tsukahara T., J Nutr., 132, 2229 (2002)
  194. Tsunehiro Jun, Matsukubo Takashi, Shiota Masao, Takaesu Yoshinori, Caries-inducing Activity of the Hydrogenated Derivative of an Isomaltooligosaccharide Mixture in Rats, 10.1271/bbb.61.1317
  195. TSUNEHIRO Jun, OKAMOTO Katsuyuki, FURUYAMA Yasuo, YATAKE Tsuneya, KANEKO Toshiyuki, Digestibility of the Hydrogenated Derivative of an Isomaltooligosaccharide Mixture by Rats, 10.1271/bbb.63.1515
  196. Tuohy K., Rouzaud G., Bruck W., Gibson G., Modulation of the Human Gut Microflora Towards Improved Health Using Prebiotics - Assessment of Efficacy, 10.2174/1381612053382331
  197. Valette Pascale, Pelenc Vincent, Djouzi Zakia, Andrieux Claude, Paul François, Monsan Pierre, Szylit Odette, Bioavailability of new synthesised glucooligosaccharides in the intestinal tract of gnotobiotic rats, 10.1002/jsfa.2740620204
  198. Vasiljevic T., Shah N.P., Probiotics—From Metchnikoff to bioactives, 10.1016/j.idairyj.2008.03.004
  199. Verbeke K., Gast, 134, 692 (2008)
  200. Vernazza Claire L., Gibson Glenn R., Rastall Robert A., Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium, 10.1111/j.1365-2672.2006.02832.x
  201. Vetere Amedeo, Gamini Amelia, Campa Cristiana, Paoletti Sergio, Regiospecific Transglycolytic Synthesis and Structural Characterization of 6-O-α-Glucopyranosyl– Glucopyranose (Isomaltose), 10.1006/bbrc.2000.3068
  202. Vinogradov Evgeny, Bock Klaus, Structural determination of some new oligosaccharides and analysis of the branching pattern of isomaltooligosaccharides from beer, 10.1016/s0008-6215(98)00119-0
  203. Vítek Vladimír, Vítek KvChromatography of sugars in body fluids, 10.1016/0006-2944(73)90107-5
  204. Vulevic Jelena, Rastall Robert A, Gibson Glenn R, Developing a quantitative approach for determining the in vitro prebiotic potential of dietary oligosaccharides, 10.1111/j.1574-6968.2004.tb09641.x
  205. J. Walker Gwen, Preparation of isomaltose oligosaccharides labelled with 14C in the non-reducing terminal unit, and their use in studies of dextranase activity, 10.1016/s0008-6215(00)82167-9
  206. Walker Gwen J., Synthesis of oligosaccharides of the isomaltose series labelled with 14C at the reducing end, 10.1016/s0008-6215(00)88097-0
  207. Wang Xiao-Dong, Rakshit S.K, Iso-oligosaccharide production by multiple forms of transferase enzymes from Aspergillus foetidus, 10.1016/s0032-9592(99)00139-9
  208. Wang Hsueh-Fang, Lim Paik-Seong, Kao Mei-Ding, Chan Elsie-C, Lin Lung-Chin, Wang Nan-Phong, Use of isomalto-oligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients, 10.1016/s1051-2276(01)92591-9
  209. Wang Yanbo, Prebiotics: Present and future in food science and technology, 10.1016/j.foodres.2008.09.001
  210. Watanabe T., Prophylactic or ameliorating agent for immunological dysfunction, Prophylactic or ameliorating agent for microbism, tumor immunological enhancer and Prophylactic or ameliorating agent for in vivo various dysfunctions and functional food comprising α(1→6)-bonded chain glucose oligomer as active ingredient (2002)
  211. Watt Gregory M, Lowden Philip AS, Flitsch Sabine L, Enzyme-catalyzed formation of glycosidic linkages, 10.1016/s0959-440x(97)80074-7
  212. Wichienchot S., Curr Issues Intestinal Microbiol., 7, 7 (2003)
  213. Wolfrom M.L., Schwab G., Quantitative analysis of gentiobiose and isomaltose in admixture, and its application to the characterization of dextrins, 10.1016/s0008-6215(00)80025-7
  214. Wong J. M.W., J Nutr., 137, 2539S (2007)
  215. Yamamoto I., Biochim Biophys Acta, 1035, 44 (1990)
  216. Yamamoto T., Biochim Biophys Acta, 1700, 189 (2004)
  217. Yamasaki Y., Agric Biol Chem., 37, 251 (1973)
  218. Yamasaki Y., Agric Biol Chem., 40, 669 (1976)
  219. YANG Y., IJI P.A., CHOCT M., Dietary modulation of gut microflora in broiler chickens: a review of the role of six kinds of alternatives to in-feed antibiotics, 10.1017/s0043933909000008
  220. Yasuda, E.H, Takaku, H. and Matsumoto, H. 1986. 61–212296. Japanese Patent, JP.
  221. Yatake T., Production, Properties and Application, 79 (1993)
  222. Yoneyama M., Saccharides sous forme de poudre, préparation et utilisations (1992)
  223. YOO SANG-HO, KWEON MEE-RA, KIM MYO-JUNG, AUH JOONG-HYUCK, JUNG DONG-SUN, KIM JEONG-RYUL, YOOK CHEOL, KIM JUNG-WAN, PARK KWAN-HWA, Branched Oligosaccharides Concentrated by Yeast Fermentation and Effectiveness as a Low Sweetness Humectant, 10.1111/j.1365-2621.1995.tb09816.x
  224. Yoo, S. K. 1997. The production of glucooligosaccharides byLeuconostoc mesenteroides
  225. ATCC 13146 and Lipomyces starkeyi ATCC 74054 (1992)
  226. Yoon Seung-Heon, Mukerjea Rupendra, Robyt John F., Specificity of yeast (Saccharomyces cerevisiae) in removing carbohydrates by fermentation, 10.1016/s0008-6215(03)00097-1
  227. Yun Jong Won, Lee Min Gyu, Song Seung Koo, Continuous production of isomalto-oligosaccharides from maltose syrup by immobilized cells of permeabilizedAureobasidium pullulans, 10.1007/bf01020841
  228. Yun J., J Korean Inst Chem Eng., 32, 875 (1994)
  229. Zhang F., Poultry Sci., 82, 657 (2003)
Bibliographic reference Goffin, Dorothee ; Delzenne, Nathalie M. ; Blecker, Christophe ; Hanon, Emilien ; Deroanne, Claude ; et. al. Will isomalto-oligosaccharides, a well-established functional food in Asia, break through the European and American market? : The status of knowledge on these prebiotics.. In: Critical Reviews in Food Science and Nutrition, Vol. 51, no. 5, p. 394-409 (2011)
Permanent URL http://hdl.handle.net/2078.1/105175