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Desloratadine 5 mg once daily improves the quality of life of patients with chronic idiopathic urticaria.

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Lachapelle, Jean-Marie [UCL] Decroix, J. Henrijean, A Roquet-Gravy, P P De Swerdt, A Vastesaeger, N.

BACKGROUND: Chronic urticaria is known to debilitate a person's quality of life via sleep disruption, itching lesions, fatigue, social isolation, energy loss and emotional/sexual difficulties. Once-daily desloratadine significantly improved the signs and symptoms of CIU. OBJECTIVE: Assess the effect of desloratadine 5 mg once daily on the quality of life of patients suffering of chronic idiopathic urticaria (CIU). Study population One-hundred twenty-one consecutive patients with CIU present for at least 6 weeks prior to inclusion and with a current flare of at least 3 weeks, were included in the study in 24 Belgian centres. RESULTS: The mean dermatology life quality index (DLQI) significantly decreased from baseline to day 7 and further to day 42. Sixty per cent and 77% of patients had a clinically significant change (i.e. a decrease of at least 2 points) at day 7 or day 42, respectively, as compared with that of day 0. Change in pruritus and size of the hives significantly correlated with the change in the score of the quality of life. One-third of patients experienced complete relief whereas in 1 of 10 patients no effect was experienced. CONCLUSIONS: Desloratadine significantly improves the quality of life of patients with chronic idiopathic urticaria as reflected by the dermatology life quality index (DLQI).

Document type Article de périodique (Journal article) – Clinical Trial, Journal Article, Multicenter Study
Publication date 2006
Journal information "Journal of the European Academy of Dermatology and Venereology : JEADV" - Vol. 20, no. 3, p. 288-92 (2006)
Peer reviewed yes
issn 0926-9959
Publication status Publié
Affiliation UCL
MESH Subject Administration, Oral ; Adult ; Belgium ; Chronic Disease ; Drug Administration Schedule ; Female ; Histamine H1 Antagonists, Non-Sedating - administration & dosage - therapeutic use ; Humans ; Loratadine - administration & dosage - analogs & derivatives - therapeutic use ; Male ; Quality of Life ; Severity of Illness Index ; Treatment Outcome ; Urticaria - drug therapy - pathology - psychology
Links
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Bibliographic reference Lachapelle, Jean-Marie ; Decroix, J. ; Henrijean, A ; Roquet-Gravy, P P ; De Swerdt, A ; et. al. Desloratadine 5 mg once daily improves the quality of life of patients with chronic idiopathic urticaria.. In: Journal of the European Academy of Dermatology and Venereology : JEADV, Vol. 20, no. 3, p. 288-92 (2006)
Permanent URL http://hdl.handle.net/2078.1/10497