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Effects of sertraline on depressive symptoms and attentional and executive functions in major depression.

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Constant, Eric [UCL] Adam, Stéphane Gillain, Benoît [UCL] Seron, Xavier [UCL] Bruyer, Raymond [UCL] Seghers, Arlette [UCL]

Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of unipolar major depression without psychotic or melancholic characteristics and all being treated with the same psychopharmacological treatment (sertraline) to investigate the changes in potential attentional and executive loss during a subacute period of treatment of 7 weeks. We compared their performance with a group of 26 control subjects who were administered the same cognitive tests. This study confirmed psychomotor slowing associated with attentional and executive disturbance in adults with major depression. Conscious attentional interference for words with a negative emotional valence also was shown. After the first weeks of treatment, the effect of the antidepressant treatment with sertraline was accompanied by a beneficial effect on psychomotor slowing on attentional and executive functions.

  1. Abas, Psychol Med, 20, 507 (1990)
  2. Austin, Psychol Med, 29, 73 (1999)
  3. Austin, J Affect Disord, 25, 21 (1992)
  4. Basso, Neuropsychology, 13, 557 (1999)
  5. Baxter Lewis R., Reduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression, 10.1001/archpsyc.1989.01810030049007
  6. BECK A. T., An Inventory for Measuring Depression, 10.1001/archpsyc.1961.01710120031004
  7. Bench, Psychol Med, 22, 607 (1992)
  8. Depression and memory in major depressive disorder, 10.1176/jnp.3.1.78
  9. Bradley, Behav Res Ther, 33, 755 (1995)
  10. Bradley, J Abnorm Psychol, 1043, 532 (1995)
  11. Buchsbaum, Biol Psychiatry, 41, 15 (1997)
  12. BYRNE D. G., Choice Reaction Times in Depressive States, 10.1111/j.2044-8260.1976.tb00020.x
  13. Calev, Psychopathology, 29, 71 (1996)
  14. Cattell, J Nerv Ment Dis, 146, 147 (1968)
  15. Content, L'Année Psychologique, 90, 551 (1990)
  16. Cornblatt, Psychiatry Res, 29, 65 (1989)
  17. Delay, L'éncéphale, 6, 497 (1963)
  18. Dolan, Psychol Med, 24, 849 (1994)
  19. 1999. Mood and memory. In: editors. Handbook of Cognition and Emotion. Chichester: Wiley. p. 193-210.
  20. 1996. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID), Clinical Version. Washington, DC: American Psychiatric Press.
  21. Fossati, Psychiatry Res, 89, 171 (1999)
  22. Furlan, Am J Geriatr Psychiatry, 9, 429 (2001)
  23. Gotlib, J Abnorm Psychol, 963, 199 (1987)
  24. Gotlib Ian H., McLachlan Anne L., Katz Albert N., Biases in Visual Attention in Depressed and Nondepressed Individuals, 10.1080/02699938808410923
  25. Grant, Biol Psychiatry, 50, 35 (2001)
  26. Krishnan, Eur Arch Psychiatry Clin Neurosci, 243, 41 (1993)
  27. Martin, J Clin Psychol, 47, 684 (1991)
  28. Left prefrontal glucose hypometabolism in the depressed state: a confirmation, 10.1176/ajp.147.10.1313
  29. Mathews, Behav Res Ther, 349, 695 (1996)
  30. Merriam, Am J Psychiatry, 156, 780 (1999)
  31. Miller, Psychiatry Res, 37, 219 (1991)
  32. Mogg Karin, Bradley Brendan P., Williams Rachel, Attentional bias in anxiety and depression: The role of awareness, 10.1111/j.2044-8260.1995.tb01434.x
  33. Nelson Erik B., Sax Kenji W., Strakowski Stephen M., Attentional Performance in Patients With Psychotic and Nonpsychotic Major Depression and Schizophrenia, 10.1176/ajp.155.1.137
  34. Purcell, Psychol Med, 27, 1277 (1997)
  35. Riedel, Drugs, 3, 245 (1995)
  36. Schmitt, J Psychopharmacol, 16, 207 (2002)
  37. 2002. E-Prime User's Guide. Pittsburgh, PA: Psychology Software Tools Inc.
  38. Siepmann, Psychopharmacology, 1683, 293 (2003)
  39. Silberman Edward K., Thinking Disorder in Depression : Logic and Strategy in an Abstract Reasoning Task, 10.1001/archpsyc.1983.01790060073009
  40. 1983. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
  41. Stroop, J Exp Psychol, 18, 643 (1935)
  42. Sweeny, Biol Psychiatry, 48, 674 (2000)
  43. Sweeny, Biol Psychiatry, 43, 584 (1998)
  44. Sweeny, J Clin Psychol, 45, 836 (1989)
  45. Trichard, Psychol Med, 25, 79 (1995)
  46. Widlocher, Eur Bull Cogn Psychol, 9, 583 (1989)
  47. Wolfe, J Affect Disord, 13, 83 (1987)
  48. 1994. Tests d'évalution de l'attention (TEA)-Version 1.02C [Tests for attention assessment]. French adaptation by North P, Leclercq M, Cremel N, Tassi P, Jeromin D, Ed. Psytest.
  49. Zuckerman, J Consult Psych, 24, 457 (1960)
Bibliographic reference Constant, Eric ; Adam, Stéphane ; Gillain, Benoît ; Seron, Xavier ; Bruyer, Raymond ; et. al. Effects of sertraline on depressive symptoms and attentional and executive functions in major depression.. In: Depression and anxiety, Vol. 21, no. 2, p. 78-89 (2005)
Permanent URL http://hdl.handle.net/2078.1/10185