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Genetics of lupus nephritis.

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Lauwerys, Bernard [UCL] Wakeland, E K

Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcgammaRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of congenic mice, bearing in a normal genetic background one single disease-associated locus, greatly improved our understanding of the mechanisms mediating the genetic contribution to the disease. In the future, the identification of disease-associated genes will open new perspectives for the development of more targeted therapies of lupus nephritis.

Document type Article de périodique (Journal article) – Journal Article, Review
Access type Accès restreint
Publication date 2005
Journal information "Lupus" - Vol. 14, no. 1, p. 2-12 (2005)
Peer reviewed yes
issn 0961-2033
Publication status Publié
Affiliations UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de rhumatologie
MESH Subject Animals ; Genetic Predisposition to Disease - genetics ; Genetic Screening ; Humans ; Lupus Nephritis - genetics - immunology ; Mice ; Models, Animal
Links
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Permanent URL http://hdl.handle.net/2078.1/10114