User menu

Genetics of lupus nephritis.

Bibliographic reference Lauwerys, Bernard ; Wakeland, E K. Genetics of lupus nephritis.. In: Lupus, Vol. 14, no. 1, p. 2-12 (2005)
Permanent URL http://hdl.handle.net/2078.1/10114
  1. Walport Mark J, 10.1186/ar586
  2. Pickering M.C., Botto M., Taylor P.R., Lachmann P.J., Walport M.J., Systemic Lupus Erythematosus, Complement Deficiency, and Apoptosis, Advances in Immunology (2001) ISBN:9780120224760 p.227-324, 10.1016/s0065-2776(01)76021-x
  3. Taylor Philip R., Carugati Anna, Fadok Valerie A., Cook H. Terence, Andrews Mark, Carroll Michael C., Savill John S., Henson Peter M., Botto Marina, Walport Mark J., A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo, 10.1084/jem.192.3.359
  4. Rupert K. L., Moulds J. M., Yang Y., Arnett F. C., Warren R. W., Reveille J. D., Myones B. L., Blanchong C. A., Yu C. Y., The Molecular Basis of Complete Complement C4A and C4B Deficiencies in a Systemic Lupus Erythematosus Patient with Homozygous C4A and C4B Mutant Genes, 10.4049/jimmunol.169.3.1570
  5. Sullivan KE, J Rheumatol, 21, 1128 (1994)
  6. Gaffney P. M., Kearns G. M., Shark K. B., Ortmann W. A., Selby S. A., Malmgren M. L., Rohlf K. E., Ockenden T. C., Messner R. P., King R. A., Rich S. S., Behrens T. W., A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families, 10.1073/pnas.95.25.14875
  7. Moser K. L., Neas B. R., Salmon J. E., Yu H., Gray-McGuire C., Asundi N., Bruner G. R., Fox J., Kelly J., Henshall S., Bacino D., Dietz M., Hogue R., Koelsch G., Nightingale L., Shaver T., Abdou N. I., Albert D. A., Carson C., Petri M., Treadwell E. L., James J. A., Harley J. B., Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees, 10.1073/pnas.95.25.14869
  8. Lindqvist Anna-Karin B, Steinsson Kristján, Johanneson Bo, Kristjánsdóttir Helga, Àrnasson Alfred, Gröndal Gerdur, Jonasson Inger, Magnusson Veronica, Sturfelt Gunnar, Truedsson Lennart, Svenungsson Elisabet, Lundberg Ingrid, Terwilliger Joseph D, Gyllensten Ulf B, Alarcón-Riquelme Marta E, A Susceptibility Locus for Human Systemic Lupus Erythematosus (hSLE1) on Chromosome 2q, 10.1006/jaut.1999.0357
  9. Moser Kathy L., Gray-McGuire Courtney, Kelly Jennifer, Asundi Neeraj, Yu Hua, Bruner Gail R., Mange Monique, Hogue Robert, Neas Barbara R., Harley John B., Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41, 10.1002/1529-0131(199909)42:9<1902::aid-anr16>3.0.co;2-g
  10. Quintero-Del-Rio A I, Kelly J A, Kilpatrick J, James J A, Harley J B, The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3), 10.1038/sj.gene.6363901
  11. Namjou B, Nath S K, Kilpatrick J, Kelly J A, Reid J, Reichlin M, James J A, Harley J B, Genome scan stratified by the presence of anti-double-stranded DNA (dsDNA) autoantibody in pedigrees multiplex for systemic lupus erythematosus (SLE) establishes linkages at 19p13.2 (SLED1) and 18q21.1 (SLED2), 10.1038/sj.gene.6363905
  12. Graham Robert R, Langefeld Carl D, Gaffney Patrick M, Ortmann Ward A, Selby Scott A, Baechler Emily C, Shark Katherine B, Ockenden Theresa C, Rohlf Kristine E, Moser Kathleen L, Brown William M, Gabriel Sherine E, Messner Ronald P, King Richard A, Horak Pavel, Elder James T, Stuart Philip E, Rich Steven S, Behrens Timothy W, 10.1186/ar319
  13. Gray-McGuire C., Moser K.L., Gaffney P.M., Kelly J., Yu H., Olson J.M., Jedrey C.M., Jacobs K.B., Kimberly R.P., Neas B.R., Rich S.S., Behrens T.W., Harley J.B., Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p16-15.2, 10.1086/316891
  14. Gaffney Patrick M., Ortmann Ward A., Selby Scott A., Shark Katherine B., Ockenden Theresa C., Rohlf Kristine E., Walgrave Nichole L., Boyum Wade P., Malmgren Michelle L., Miller Michael E., Kearns Grainne M., Messner Ronald P., King Richard A., Rich Stephen S., Behrens Timothy W., Genome Screening in Human Systemic Lupus Erythematosus: Results from a Second Minnesota Cohort and Combined Analyses of 187 Sib-Pair Families, 10.1086/302767
  15. Moser Kathy L., Gray-McGuire Courtney, Kelly Jennifer, Asundi Neeraj, Yu Hua, Bruner Gail R., Mange Monique, Hogue Robert, Neas Barbara R., Harley John B., Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41, 10.1002/1529-0131(199909)42:9<1902::aid-anr16>3.0.co;2-g
  16. Su K, Wu J, Edberg J C, McKenzie S E, Kimberly R P, Genomic organization of classical human low-affinity Fcγ receptor genes, 10.1038/sj.gene.6363879
  17. Zu�iga Ricardo, Ng Sonia, Peterson Margaret G. E., Reveille John D., Baethge Bruce A., Alarc�n Graciela S., Salmon Jane E., Low-binding alleles of Fc? receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients, 10.1002/1529-0131(200102)44:2<361::aid-anr54>3.0.co;2-g
  18. Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, Juji T, Tokunaga K, Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese, 10.1038/sj.gene.6363639
  19. Manger K, Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms, 10.1136/ard.61.9.786
  20. Dijstelbloem Hilde M., Bijl Marc, Fijnheer Rob, Scheepers Ronald H. M., Oost Wia W., Jansen Marc D., Sluiter Wim J., Limburg Pieter C., Derksen Ronald H. W. M., Van De Winkel Jan G. J., Kallenberg Cees G. M., Fcγ receptor polymorphisms in systemic lupus erythematosus: Association with disease and in vivo clearance of immune complexes, 10.1002/1529-0131(200012)43:12<2793::aid-anr20>3.0.co;2-6
  21. Edberg Jeffrey C., Langefeld Carl D., Wu Jianming, Moser Kathy L., Kaufman Kenneth M., Kelly Jennifer, Bansal Vipin, Brown W. Mark, Salmon Jane E., Rich Stephen S., Harley John B., Kimberly Robert P., Genetic linkage and association of Fc? receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus, 10.1002/art.10438
  22. Kyogoku Chieko, Dijstelbloem Hilde M., Tsuchiya Naoyuki, Hatta Yoko, Kato Hitoshi, Yamaguchi Akihiro, Fukazawa Toru, Jansen Marc D., Hashimoto Hiroshi, van de Winkel Jan G. J., Kallenberg Cees G. M., Tokunaga Katsushi, Fc? receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution ofFCGR2B to genetic susceptibility, 10.1002/art.10257
  23. Brundula Veronika, Rivas Liliana J., Blasini Ana M., Salazar Susana, Stekman Ivan L., Rodr�guez Mart�n A., Diminished levels of T cell receptor ? chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus, 10.1002/1529-0131(199909)42:9<1908::aid-anr17>3.0.co;2-7
  24. Liossis S N, Ding X Z, Dennis G J, Tsokos G C, Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain., 10.1172/jci1457
  25. Nambiar Madhusoodana P., Enyedy Edith J., Warke Vishal G., Krishnan Sandeep, Dennis Gregory, Wong Henry K., Kammer Gary M., Tsokos George C., T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor ? chain messenger RNA, 10.1002/1529-0131(200106)44:6<1336::aid-art226>3.0.co;2-8
  26. Nambiar Madhusoodana P, Enyedy Edith J, Warke Vishal G, Krishnan Sandeep, Dennis Gregory, Kammer Gary M, Tsokos George C, Polymorphisms/Mutations of TCR-ζ-Chain Promoter and 3′ Untranslated Region and Selective Expression of TCR ζ-Chain with an Alternatively Spliced 3′ Untranslated Region in Patients with Systemic Lupus Erythematosus, 10.1006/jaut.2000.0475
  27. Kyogoku Chieko, Ortmann Ward A., Lee Annette, Selby Scott, Carlton Victoria E.H., Chang Monica, Ramos Paula, Baechler Emily C., Batliwalla Franak M., Novitzke Jill, Williams Adrienne H., Gillett Clarence, Rodine Peter, Graham Robert R., Ardlie Kristin G., Gaffney Patrick M., Moser Kathy L., Petri Michelle, Begovich Ann B., Gregersen Peter K., Langefeld Carl D., Behrens Timothy W., Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE, 10.1086/423790
  28. Jury Elizabeth C., Kabouridis Panagiotis S., Flores-Borja Fabian, Mageed Rizgar A., Isenberg David A., Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus, 10.1172/jci200420345
  29. Tsao Betty P., Cantor Rita M., Grossman Jennifer M., Shen Nan, Teophilov Nickolay T., Wallace Daniel J., Arnett Frank C., Hartung Klaus, Goldstein Rose, Kalunian Kenneth C., Hahn Bevra H., Rotter Jerome I., PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus, 10.1172/jci5967
  30. Criswell LA, J Clin Invest, 105, 1501 (2000)
  31. Delrieu O., Michel M., Franc�s C., Meyer O., Michel C., Wittke F., Crassard I., Bach J. F., Tournier-Lasserve E., Piette J. C., , Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome, 10.1002/1529-0131(199910)42:10<2194::aid-anr22>3.0.co;2-u
  32. Komata T., Tsuchiya N., Matsushita M., Hagiwara K., Tokunaga K., Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus, 10.1034/j.1399-0039.1999.530602.x
  33. Morita Chika, Horiuchi Takahiko, Tsukamoto Hiroshi, Hatta Nobuaki, Kikuchi Yuji, Arinobu Yojiro, Otsuka Takeshi, Sawabe Takuya, Harashima Shin-Ichi, Nagasawa Kohei, Niho Yoshiyuki, Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: Molecular and functional analysis, 10.1002/1529-0131(200112)44:12<2819::aid-art469>3.0.co;2-2
  34. Tsuchiya N, Komata T, Matsushita M, Ohashi J, Tokunaga K, New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus, 10.1038/sj.gene.6363700
  35. Takahashi M., Hashimoto H., Akizuki M., Sasazuki T., Nishikimi N., Ouchi H., Kobayashi Y., Numano F., Kimura A., Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese, 10.1034/j.1399-0039.2001.057001066.x
  36. Lee E.B, Yoo J.E, Lee Y.J, Choi Y.J, Park K.S, Song Y.W, Tumor necrosis factor receptor 2 polymorphism in systemic lupus erythematosus: no association with disease, 10.1016/s0198-8859(01)00280-4
  37. Tsuchiya N, Kawasaki A, Tsao B P, Komata T, Grossman J M, Tokunaga K, Analysis of the association of HLA-DRB1, TNFα promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test, 10.1038/sj.gene.6363783
  38. Houssiau FA, Lefebvre C., Vanden Berghe M., Lambert M., Devogelaer J-P., Renauld J-C., Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity, 10.1177/096120339500400510
  39. Llorente Luis, Richaud-Patin Yvonne, García-Padilla Carlos, Claret Emmanuel, Jakez-Ocampo Juan, Cardiel Mario H., Alcocer-Varela Jorge, Grangeot-Keros Liliane, Alarcón-Segovia Donato, Wijdenes John, Galanaud Pierre, Emilie Dominique, Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus, 10.1002/1529-0131(200008)43:8<1790::aid-anr15>3.0.co;2-2
  40. Llorente Luis, Richaud-Patin Yvonne, Couderc Jacques, Alarcon-Segovia Donato, Ruiz-Soto Rodrigo, Alcocer-Castillejos Natasha, Alcocer-Varela Jorge, Granados Julio, Bahena Susana, Galanaud Pierre, Emilie Dominique, Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus, 10.1002/art.1780400810
  41. Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J. C., Alarcon-Segovia D., Galanaud P., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus, 10.1084/jem.181.3.839
  42. Lauwerys Bernard R., Garot Nathalie, Renauld Jean‐Christophe, Houssiau Frédéric A., Interleukin‐10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients, 10.1002/1529-0131(200009)43:9<1976::aid-anr8>3.0.co;2-v
  43. Gibson A. W., Edberg J. C., Wu J., Westendorp R. G. J., Huizinga T. W. J., Kimberly R. P., Novel Single Nucleotide Polymorphisms in the Distal IL-10 Promoter Affect IL-10 Production and Enhance the Risk of Systemic Lupus Erythematosus, 10.4049/jimmunol.166.6.3915
  44. Prokunina Ludmila, Castillejo-López Casimiro, Öberg Fredrik, Gunnarsson Iva, Berg Louise, Magnusson Veronica, Brookes Anthony J., Tentler Dmitry, Kristjansdóttir Helga, Gröndal Gerdur, Bolstad Anne Isine, Svenungsson Elisabet, Lundberg Ingrid, Sturfelt Gunnar, Jönssen Andreas, Truedsson Lennart, Lima Guadalupe, Alcocer-Varela Jorge, Jonsson Roland, Gyllensten Ulf B., Harley John B., Alarcón-Segovia Donato, Steinsson Kristján, Alarcón-Riquelme Marta E., A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans, 10.1038/ng1020
  45. Ferreiros-Vidal Isabel, Gomez-Reino Juan J., Barros Francisco, Carracedo Angel, Carreira Patricia, Gonzalez-Escribano Francisca, Liz Myriam, Martin Javier, Ordi Josep, Vicario Jose L., Gonzalez Antonio, Association of PDCD1 with susceptibility to systemic lupus erythematosus : Evidence of population-specific effects, 10.1002/art.20436
  46. Drappa Jörn, Vaishnaw Akshay K., Sullivan Kathleen E., Chu Jia-Li, Elkon Keith B., FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity, 10.1056/nejm199611283352204
  47. Izui Shozo, Merino RamÓN, Fossati Liliane, Iwamoto Masahiro, The Role of the Yaa Gene in Lupus Syndrome, 10.3109/08830189409061728
  48. Mohan Chandra, Morel Laurence, Yang Ping, Wakeland Edward K., Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice, 10.1002/1529-0131(199809)41:9<1652::aid-art17>3.0.co;2-w
  49. Morel Laurence, Rudofsky Ulrich H., Longmate Jeffrey A., Schiffenbauer Joel, Wakeland Edward K., Polygenic control of susceptibility to murine systemic lupus erythematosus, 10.1016/1074-7613(94)90100-7
  50. Drake C. G., Babcock S. K., Palmer E., Kotzin B. L., Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice., 10.1073/pnas.91.9.4062
  51. Kono D. H., Burlingame R. W., Owens D. G., Kuramochi A., Balderas R. S., Balomenos D., Theofilopoulos A. N., Lupus susceptibility loci in New Zealand mice., 10.1073/pnas.91.21.10168
  52. Vyse T J, Drake C G, Rozzo S J, Roper E, Izui S, Kotzin B L, Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice., 10.1172/jci118975
  53. Rozzo S. J., Vyse T. J., Drake C. G., Kotzin B. L., Effect of genetic background on the contribution of New Zealand Black loci to autoimmune lupus nephritis, 10.1073/pnas.93.26.15164
  54. Vyse TJ, J Immunol, 158, 5566 (1997)
  55. Hogarth MB, J Immunol, 161, 2753 (1998)
  56. Santiago Marie-Laure, Mary Charles, Parzy Daniel, Jacquet Chantal, Montagutelli Xavier, Parkhouse R. Michael E., Lemoine Robert, Izui Shozo, Reininger Luc, Linkage of a major quantitative trait locus toYaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice, 10.1002/(sici)1521-4141(199812)28:12<4257::aid-immu4257>3.0.co;2-h
  57. Morel *, † , Chandra Mohan Laurence, Yu Ying, Schiffenbauer †, ‡ , Ulri Joel, Tian Nana, Longmate Jeff A., Multiplex inheritance of component phenotypes in a murine model of lupus, 10.1007/s003359900964
  58. Wither Joan E., Paterson Andrew D., Vukusic Brian, Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage toNba2, 10.1002/1521-4141(200002)30:2<356::aid-immu356>3.0.co;2-h
  59. Haywood Michelle E. K., Hogarth Maxine B., Slingsby Jason H., Rose S. Jane, Allen Penny J., Thompson E. Mary, Maibaum Michael A., Chandler Phillip, Davies Kevin A., Simpson Elizabeth, Walport Mark J., Morley Bernard J., Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice, 10.1002/1529-0131(200002)43:2<349::aid-anr14>3.0.co;2-m
  60. Rozzo S. J., Vyse T. J., Menze K., Izui S., Kotzin B. L., Enhanced Susceptibility to Lupus Contributed from the Nonautoimmune C57BL/10, But Not C57BL/6, Genome, 10.4049/jimmunol.164.10.5515
  61. Xie S., Chang S., Yang P., Jacob C., Kaliyaperumal A., Datta S. K., Mohan C., Genetic Contributions of Nonautoimmune SWR Mice Toward Lupus Nephritis, 10.4049/jimmunol.167.12.7141
  62. Rahman Z. S., Tin S.-K., Buenaventura P.-N. L., Ho C.-H., Yap E. P. H., Yong R. Y. Y., Koh D.-R., A Novel Susceptibility Locus On Chromosome 2 in the (New Zealand Black x New Zealand White)F1 Hybrid Mouse Model of Systemic Lupus Erythematosus, 10.4049/jimmunol.168.6.3042
  63. Kamogawa Junji, Terada Miho, Mizuki Shinichi, Nishihara Miyuki, Yamamoto Haruyasu, Mori Shiro, Abe Yoriko, Morimoto Koji, Nakatsuru Syuichi, Nakamura Yusuke, Nose Masato, Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains, 10.1002/art.10193
  64. Bolland Silvia, Yim Young-Sun, Tus Katalin, Wakeland Edward K., Ravetch Jeffrey V., Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/−Mice, 10.1084/jem.20020165
  65. Haywood M. E. K., Rogers N. J., Rose S. J., Boyle J., McDermott A., Rankin J. M., Thiruudaian V., Lewis M. R., Fossati-Jimack L., Izui S., Walport M. J., Morley B. J., Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease, 10.4049/jimmunol.173.7.4277
  66. Rozzo Stephen J, Allard John D, Choubey Divaker, Vyse Timothy J, Izui Shozo, Peltz Gary, Kotzin Brian L, Evidence for an Interferon-Inducible Gene, Ifi202, in the Susceptibility to Systemic Lupus, 10.1016/s1074-7613(01)00196-0
  67. Morel L., Yu Y., Blenman K. R., Caldwell R. A., Wakeland E. K., Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain, 10.1007/s003359900098
  68. Morel L, J Immunol, 158, 6019 (1997)
  69. Funk J L, Cordaro L A, Wei H, Benjamin J B, Yocum D E, Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis., 10.1172/jci728
  70. Sobel ES, J Immunol, 162, 2415 (1999)
  71. Mohan Chandra, Morel Laurence, Yang Ping, Watanabe Hiroshi, Croker Byron, Gilkeson Gary, Wakeland Edward K., Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies, 10.1172/jci5827
  72. Sobel E. S., Satoh M., Chen Y., Wakeland E. K., Morel L., The Major Murine Systemic Lupus Erythematosus Susceptibility Locus Sle1 Results in Abnormal Functions of Both B and T Cells, 10.4049/jimmunol.169.5.2694
  73. Mohan C, J Immunol, 159, 454 (1997)
  74. Mohan C, J Immunol, 162, 6492 (1999)
  75. Morel L., Croker B. P., Blenman K. R., Mohan C., Huang G., Gilkeson G., Wakeland E. K., Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains, 10.1073/pnas.97.12.6670
  76. Morel Laurence, Tian Xiang-Hong, Croker Byron P, Wakeland Edward K, Epistatic Modifiers of Autoimmunity in a Murine Model of Lupus Nephritis, 10.1016/s1074-7613(00)80088-6
  77. Waters Samuel T., McDuffie Marcia, Bagavant Harini, Deshmukh Umesh S., Gaskin Felicia, Jiang Chao, Tung Kenneth S.K., Fu Shu Man, Breaking Tolerance to Double Stranded DNA, Nucleosome, and Other Nuclear Antigens Is Not Required for the Pathogenesis of Lupus Glomerulonephritis, 10.1084/jem.20031519
  78. Xie Chun, Zhou Xin J., Liu Xuebin, Mohan Chandra, Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain, 10.1002/art.10887
  79. Morel L., Blenman K. R., Croker B. P., Wakeland E. K., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes, 10.1073/pnas.98.4.1787
  80. Boackle Susan A, Holers V.Michael, Chen Xiaojiang, Szakonyi Gerda, Karp David R, Wakeland Edward K, Morel Laurence, Cr2, a Candidate Gene in the Murine Sle1c Lupus Susceptibility Locus, Encodes a Dysfunctional Protein, 10.1016/s1074-7613(01)00228-x
  81. Wu X., Jiang N., Deppong C., Singh J., Dolecki G., Mao D., Morel L., Molina H. D., A Role for the Cr2 Gene in Modifying Autoantibody Production in Systemic Lupus Erythematosus, 10.4049/jimmunol.169.3.1587
  82. Giraldo P, Transgenic Res, 50, 26 (2001)
  83. Kyogoku Chieko, Ortmann Ward A., Lee Annette, Selby Scott, Carlton Victoria E.H., Chang Monica, Ramos Paula, Baechler Emily C., Batliwalla Franak M., Novitzke Jill, Williams Adrienne H., Gillett Clarence, Rodine Peter, Graham Robert R., Ardlie Kristin G., Gaffney Patrick M., Moser Kathy L., Petri Michelle, Begovich Ann B., Gregersen Peter K., Langefeld Carl D., Behrens Timothy W., Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE, 10.1086/423790
  84. Bennett Lynda, Palucka A. Karolina, Arce Edsel, Cantrell Victoria, Borvak Josef, Banchereau Jacques, Pascual Virginia, Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood, 10.1084/jem.20021553
  85. Han G-M, Chen S-L, Shen N, Ye S, Bao C-D, Gu Y-Y, Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray, 10.1038/sj.gene.6363966
  86. Peterson Karin S., Huang Jing-Feng, Zhu Jessica, D’Agati Vivette, Liu Xuejun, Miller Nancy, Erlander Mark G., Jackson Michael R., Winchester Robert J., Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli, 10.1172/jci200419139
  87. Mitchell D. A., Pickering M. C., Warren J., Fossati-Jimack L., Cortes-Hernandez J., Cook H. T., Botto M., Walport M. J., C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression, 10.4049/jimmunol.168.5.2538
  88. Botto Marina, Dell' Agnola Chiara, Bygrave Anne E., Thompson E. Mary, Cook H. Terence, Petry Franz, Loos Michael, Pandolfi Pier Paolo, Walport Mark J., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies, 10.1038/ng0598-56
  89. Möröy Tarik, Napirei Markus, Karsunky Holger, Zevnik Branko, Stephan Harald, Mannherz Hans Georg, 10.1038/76032
  90. Pepys M.B., Bickerstaff M.C.M., Botto M., Hutchinson W.L., Herbert J., Tennent G.A., Bybee A., Mitchell D.A., Cook H.T., Butler P.J.G., Walport M.J., 10.1038/9544
  91. Bao L., Haas M., Boackle S. A., Kraus D. M., Cunningham P. N., Park P., Alexander J. J., Anderson R. K., Culhane K., Holers V. M., Quigg R. J., Transgenic Expression of a Soluble Complement Inhibitor Protects Against Renal Disease and Promotes Survival in MRL/lpr Mice, 10.4049/jimmunol.168.7.3601
  92. Kuo Philip, Bynoe Margaret S., Wang Chuansheng, Diamond Betty, Bcl-2 leads to expression of anti-DNA B cells but no nephritis: a model for a clinical subset, 10.1002/(sici)1521-4141(199910)29:10<3168::aid-immu3168>3.0.co;2-h
  93. Zhang Y., Schlossman S. F., Edwards R. A., Ou C.-N., Gu J., Wu M. X., Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice, 10.1073/pnas.022326699
  94. Drappa Jorn, Kamen Lynn A., Chan Elena, Georgiev Maria, Ashany Dalit, Marti Francesc, King Philip D., Impaired T Cell Death and Lupus-like Autoimmunity in T Cell–specific Adapter Protein–deficient Mice, 10.1084/jem.20021358
  95. Gross Jane A., Johnston Janet, Mudri Sherri, Enselman Rachel, Dillon Stacey R., Madden Karen, Xu Wenfeng, Parrish-Novak Julia, Foster Don, Lofton-Day Cathy, Moore Margaret, Littau Alisa, Grossman Angelika, Haugen Harald, Foley Kevin, Blumberg Hal, Harrison Kim, Kindsvogel Wayne, Clegg Christopher H., 10.1038/35010115
  96. Khare S. D., Sarosi I., Xia X.-Z., McCabe S., Miner K., Solovyev I., Hawkins N., Kelley M., Chang D., Van G., Ross L., Delaney J., Wang L., Lacey D., Boyle W. J., Hsu H., Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice, 10.1073/pnas.97.7.3370
  97. Moore P. A., BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator, 10.1126/science.285.5425.260
  98. Zhang J., Roschke V., Baker K. P., Wang Z., Alarcon G. S., Fessler B. J., Bastian H., Kimberly R. P., Zhou T., Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus, 10.4049/jimmunol.166.1.6
  99. Cheema Gurtej S., Roschke Viktor, Hilbert David M., Stohl William, Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases, 10.1002/1529-0131(200106)44:6<1313::aid-art223>3.0.co;2-s
  100. Iizuka J, Lab Invest, 78, 1523 (1998)
  101. Seery JP, J Immunol, 162, 7241 (1999)
  102. Seery J. P., Carroll J. M., Cattell V., Watt F. M., Antinuclear Autoantibodies and Lupus Nephritis in Transgenic Mice Expressing Interferon   in the Epidermis, 10.1084/jem.186.9.1451
  103. Cornall Richard J, Cyster Jason G, Hibbs Margaret L, Dunn Ashley R, Otipoby Kevin L, Clark Edward A, Goodnow Christopher C, Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection, 10.1016/s1074-7613(00)80554-3
  104. Zeng Defu, Dick Michael, Cheng Lirong, Amano Masahiko, Dejbakhsh-Jones Sussan, Huie Philip, Sibley Richard, Strober Samuel, Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines, 10.1084/jem.187.4.525
  105. Nishimura Hiroyuki, Nose Masato, Hiai Hiroshi, Minato Nagahiro, Honjo Tasuku, Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor, 10.1016/s1074-7613(00)80089-8
  106. Johansson C, Castillejo-López C, Johanneson B, Svenungsson E, Gunnarsson I, Frostegård J, Sturfelt G, Truedsson L, Löfström B, Alcocer-Varela J, Lundberg I, Gyllensten U B, Alarcón-Segovia D, Alarcón-Riquelme M E, Association analysis with microsatellite and SNP markers does not support the involvement of BCL-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families, 10.1038/sj.gene.6363688
  107. Jiang Yi, Ohtsuji Mareki, Abe Masaaki, Li Na, Xiu Yan, Wen Xiang, Shirai Toshikazu, Hirose Sachiko, Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype, 10.1007/s00251-001-0396-6