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Natural products active against African trypanosomes: a step towards new drugs

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Hoet, Sara [UCL] Opperdoes, Frederik [UCL] Brun, Reto Quetin-Leclercq, Joëlle [UCL]

This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp.,T congolense and T vivax) isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from he mid-1980s up to June 2003 is reviewed and 89 references are cited.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't, Review
Access type Accès libre
Publication date 2004
Language Anglais
Journal information "Natural Product Reports : a journal of current development in bioorganic chemistry" - Vol. 21, no. 3, p. 353-364 (2004)
Peer reviewed yes
Publisher Royal Society of Chemistry ((United Kingdom) Cambridge, England)
issn 0265-0568
e-issn 1460-4752
Publication status Publié
Affiliations UCL - MD/FARM - Ecole de pharmacie
UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Africa ; Alkaloids - chemistry - pharmacology ; Animals ; Biological Products - chemistry - pharmacology ; Molecular Structure ; Phenols - chemistry - pharmacology ; Quinones - chemistry - pharmacology ; Terpenes - chemistry - pharmacology ; Trypanosoma - drug effects
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Bibliographic reference Hoet, Sara ; Opperdoes, Frederik ; Brun, Reto ; Quetin-Leclercq, Joëlle. Natural products active against African trypanosomes: a step towards new drugs. In: Natural Product Reports : a journal of current development in bioorganic chemistry, Vol. 21, no. 3, p. 353-364 (2004)
Permanent URL http://hdl.handle.net/2078.1/9856