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Human herpesvirus 8 and Epstein-Barr virus-related monotypic large B-cell lymphoproliferative disorder coexisting with mixed variant of Castleman's disease in a lymph node of a renal transplant recipient.

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Théate, Ivan [UCL] Michaux, Lucienne [UCL] Squifflet, Jean-Paul [UCL] Martin, Antoine Raphael, Martine

Human herpesvirus 8 (HHV8) has been related to some malignant lymphoproliferations, including post-transplant lymphoproliferative disorders (PTLD). We describe a case of a HHV8 and Epstein-Barr virus (EBV) positive large B-cell lymphoproliferation coexisting with Castleman's disease in the same lymph node of a long-term renal transplant recipient. Biopsy revealed mixed type of Castleman's disease and anaplastic cells showing IgA restriction, although molecular analysis failed to detect monoclonality. Only large cells were co-infected by both EBV and HHV8. After reduction of immunosuppression, the lesion partially regressed. After 1 yr, local evolution required surgery followed by irradiation. The present case represents a unique form of localized monotypic but polyclonal large cell PTLD associated with Castleman's disease. It can be added to PTLD with HHV8 and EBV co-infection.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Journal information "Clinical transplantation" - Vol. 17, no. 5, p. 451-4 (2003)
Peer reviewed yes
issn 0902-0063
Affiliations UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - MD/MINT - Département de médecine interne
MESH Subject Adult ; B-Lymphocytes - pathology ; Epstein-Barr Virus Infections - complications - pathology ; Giant Lymph Node Hyperplasia - complications - pathology - virology ; Herpesviridae Infections - complications - pathology ; Herpesvirus 8, Human ; Humans ; Immunocompromised Host ; Kidney Transplantation ; Lymph Nodes - pathology - virology ; Male
Links
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Bibliographic reference Théate, Ivan ; Michaux, Lucienne ; Squifflet, Jean-Paul ; Martin, Antoine ; Raphael, Martine. Human herpesvirus 8 and Epstein-Barr virus-related monotypic large B-cell lymphoproliferative disorder coexisting with mixed variant of Castleman's disease in a lymph node of a renal transplant recipient.. In: Clinical transplantation, Vol. 17, no. 5, p. 451-4 (2003)
Permanent URL http://hdl.handle.net/2078.1/9703