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Comparison of FEV1 and specific airway conductance in assessing airway response to occupational agents.

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Larbanois, Alexandra [UCL] Delwiche, J-P [UCL] Jamart, Jacques [UCL] Vandenplas, Olivier [UCL]

BACKGROUND: There is theoretical evidence that specific airway conductance (SGaw) could be more reliable than forced expiratory volume in 1 s (FEV1) for assessing changes in airway calibre. We investigated the changes in FEV1 and SGaw when assessing bronchial responses to occupational agents. METHODS: SGaw and FEV1 were measured during inhalation challenges with various occupational agents in 174 consecutive subjects investigated for possible occupational asthma. RESULTS: A decline in SGaw of 50% or greater was documented in 77 of 90 subjects (86%) who showed a >/=20% fall in FEV1 and in 11 of 84 subjects (13%) who failed to demonstrate such a fall in FEV1. Among subjects who developed a >/=20% fall in FEV1, those who failed to develop a >/=50% decline in SGaw had a lower baseline SGaw than those who did. Among the group without a >/=20% fall in FEV1, a >/=50% decrease in SGaw was associated with either an 'intermediate' fall in FEV1 (between 15 and 17% from baseline value) (n = 4), a significant postchallenge increase in nonspecific bronchial hyper-responsiveness to histamine (n = 2), or both features (n = 3). CONCLUSIONS: A decline in SGaw of 50% or greater may provide useful complementary evidence of a bronchial response during challenges that produce equivocal results in FEV1.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Journal information "Allergy" - Vol. 58, no. 12, p. 1256-60 (2003)
Peer reviewed yes
issn 0105-4538
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
MESH Subject Adolescent ; Adult ; Asthma - etiology - physiopathology ; Bronchi - physiology ; Bronchial Provocation Tests - methods ; Female ; Forced Expiratory Volume - drug effects ; Functional Residual Capacity - drug effects ; Humans ; Male ; Middle Aged ; Occupational Diseases - etiology ; Occupational Exposure - adverse effects
Keywords Airway conductance ; Asthma ; Bronchial provocation tests ; Occupational disease
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Bibliographic reference Larbanois, Alexandra ; Delwiche, J-P ; Jamart, Jacques ; Vandenplas, Olivier. Comparison of FEV1 and specific airway conductance in assessing airway response to occupational agents.. In: Allergy, Vol. 58, no. 12, p. 1256-60 (2003)
Permanent URL http://hdl.handle.net/2078.1/9663