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Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?

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Kadhim, Hazim [UCL] Kahn, André Sébire, Guillaume

Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 2003
Journal information "Neurology" - Vol. 61, no. 9, p. 1256-1259 (2003)
Peer reviewed yes
issn 0028-3878
e-issn 1526-632X
Affiliation UCL - MD/NOPS - Département de neurologie et de psychiatrie
MESH Subject Arcuate Nucleus - pathology ; Brain - pathology ; Brain Chemistry ; Brain Stem - pathology ; Cytokines - analysis ; Female ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Interleukin-1 - analysis ; Interleukin-6 - analysis ; Male ; Neurons - pathology ; Organ Size ; Sudden Infant Death - etiology - pathology ; Syndrome ; Tumor Necrosis Factor-alpha - analysis
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Bibliographic reference Kadhim, Hazim ; Kahn, André ; Sébire, Guillaume. Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?. In: Neurology, Vol. 61, no. 9, p. 1256-1259 (2003)
Permanent URL http://hdl.handle.net/2078.1/9660