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Massive amoxycillin crystalluria causing anuric acute renal failure.

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Labriola, Laura [UCL] Jadoul, Michel [UCL] Daudon, M Pirson, Yves [UCL] Lambert, Michel [UCL]

The authors report the case of a 45-year-old woman admitted for pneumonia who presented anuric acute renal failure after 12 days of intravenous amoxycillin-clavulanate treatment. Acute renal failure resolved rapidly and completely after antibiotic withdrawal. Analysis of the first post-anuric urine specimen showed many crystals. Infrared spectrophotometry revealed that the crystals were composed of trihydrated amoxycillin. The possibility of intrarenal obstruction due to massive drug crystalluria should not be overlooked in the face of abrupt anuria.

Document type Article de périodique (Journal article) – Article de recherche – Case Reports, Journal Article
Access type Accès interdit
Publication date 2003
Language Anglais
Journal information "Clinical Nephrology" - Vol. 59, no. 6, p. 455-457 (2003)
Peer reviewed yes
Publisher Dustri-Verlag Dr. Karl Feistle ((Germany) Oberhaching)
issn 0301-0430
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
MESH Subject Amoxicillin - urine ; Amoxicillin-Potassium Clavulanate Combination - adverse effects - therapeutic use ; Anuria - chemically induced ; Crystallization ; Drug Therapy, Combination - adverse effects - therapeutic use ; Female ; Humans ; Kidney Failure, Acute - chemically induced ; Middle Aged ; Pneumonia - drug therapy
Keywords Amoxycillin ; Anuria ; Crystalluria ; Acute renal ; Failure
Links
Bibliographic reference Labriola, Laura ; Jadoul, Michel ; Daudon, M ; Pirson, Yves ; Lambert, Michel. Massive amoxycillin crystalluria causing anuric acute renal failure.. In: Clinical Nephrology, Vol. 59, no. 6, p. 455-457 (2003)
Permanent URL http://hdl.handle.net/2078.1/9505