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Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity.

Bibliographic reference Lauwerys, Bernard ; Van Snick, Jacques ; Houssiau, Frédéric. Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity.. In: Lupus, Vol. 11, no. 6, p. 384-7 (2002)
Permanent URL http://hdl.handle.net/2078.1/9205
  1. Gillessen Silke, Carvajal Daisy, Ling Ping, Podlaski Frank J., Stremlo Donna L., Familletti Philip C., Gubler Ueli, Presky David H., Stern Alvin S., Gately Maurice K., Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist, 10.1002/eji.1830250133
  2. Heinzel FP, J Immunol, 158, 4381 (1997)
  3. Ling P, J Immunol, 154, 116 (1995)
  4. Liu Tie Fu, Jones Brian M., IMPAIRED PRODUCTION OF IL-12 SYSTEMIC LUPUS ERYTHEMATOSUS. I. EXCESSIVE PRODUCTION OF IL-10 SUPPRESSES PRODUCTION OF IL-12 BY MONOCYTES, 10.1006/cyto.1997.0268
  5. Liu Tie Fu, Jones Brian M., IMPAIRED PRODUCTION OF IL-12 IN SYSTEM LUPUS ERYTHEMATOSUS. II: IL-12 PRODUCTION IN VITRO IS CORRELATED NEGATIVELY WITH SERUM IL-10, POSITIVELY WITH SERUM IFN-γ AND NEGATIVELY WITH DISEASE ACTIVITY IN SLE, 10.1006/cyto.1997.0269
  6. Liu Tie Fu, Jones Brian M., Wong Raymond W.S., Srivastava Gopesh, IMPAIRED PRODUCTION OF IL-12 IN SYSTEMIC LUPUS ERYTHEMATOSUS. III: DEFICIENT IL-12p40 GENE EXPRESSION AND CROSS-REGULATION OF IL-12, IL-10 AND IFN-γ GENE EXPRESSION, 10.1006/cyto.1999.0512
  7. Wong C K, Ho CY Y, Li EK, Lam CWK, Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus, 10.1191/096120300678828703
  8. Wong C. K., Li E. K., Ho C. Y., Lam C. W. K., Elevation of plasma interleukin‐18 concentration is correlated with disease activity in systemic lupus erythematosus, 10.1093/rheumatology/39.10.1078
  9. TOKANO, MORIMOTO, KANEKO, AMANO, NOZAWA, TAKASAKI, HASHIMOTO, Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)-relation to Th1- and Th2-derived cytokines, 10.1046/j.1365-2249.1999.00862.x
  10. Oppmann Birgit, Lesley Robin, Blom Bianca, Timans Jackie C, Xu Yuming, Hunte Brisdell, Vega Felix, Yu Nancy, Wang Jing, Singh Komal, Zonin Francesca, Vaisberg Elena, Churakova Tatyana, Liu Man-ru, Gorman Daniel, Wagner Janet, Zurawski Sandra, Liu Yong-Jun, Abrams John S, Moore Kevin W, Rennick Donna, de Waal-Malefyt Rene, Hannum Charles, Bazan J.Fernando, Kastelein Robert A, Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12, 10.1016/s1074-7613(00)00070-4
  11. Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J. C., Alarcon-Segovia D., Galanaud P., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus, 10.1084/jem.181.3.839
  12. HOUSSIAU F. A., MASCART-LEMONE F., STEVENS M., LIBIN M., DEVOGELAER J.-P., GOLDMAN M., RENAULD J.-C., IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC), 10.1046/j.1365-2249.1997.d01-1009.x
  13. Lauwerys Bernard R., Garot Nathalie, Renauld Jean‐Christophe, Houssiau Frédéric A., Interleukin‐10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients, 10.1002/1529-0131(200009)43:9<1976::aid-anr8>3.0.co;2-v
  14. Kalinski P., Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer, 10.1182/blood.v97.11.3466
  15. Ha SJ, J Immunol, 163, 2902 (1999)