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Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.

Bibliographic reference Lesterhuis, W Joost ; Schreibelt, Gerty ; Scharenborg, Nicole M ; Brouwer, H Marylène H ; Gerritsen, Marie-Jeanne P ; et. al. Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.. In: Cancer Immunology Immunotherapy, Vol. 60, no. 2, p. 249-60 (2011)
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  1. Banchereau Jacques, Steinman Ralph M., 10.1038/32588
  2. Lesterhuis W.J., Aarntzen E.H.J.G., De Vries I.J.M., Schuurhuis D.H., Figdor C.G., Adema G.J., Punt C.J.A., Dendritic cell vaccines in melanoma: From promise to proof?, 10.1016/j.critrevonc.2007.12.007
  3. Banchereau J, Palucka AK, Dhodapkar M, Burkeholder S, Taquet N, Rolland A, Taquet S, Coquery S, Wittkowski KM, Bhardwaj N, Pineiro L, Steinman R, Fay J (2001) Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res 61:6451–6458
  4. de Vries IJM, Lesterhuis WJ, Scharenborg NM, Engelen LPH, Ruiter DJ, Gerritsen MJP, Croockewit S, Britten CM, Torensma R, Adema GJ, Figdor CG, Punt CJA (2003) Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients. Clin Cancer Res 9:5091–5100
  5. de Vries IJM, Krooshoop DJEB, Scharenborg NM, Lesterhuis WJ, Diepstra JHS, van Muijen GNP, Strijk SP, Ruers TJ, Boerman OC, Oyen WJG, Adema GJ, Punt CJA, Figdor CG (2003) Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res 63:12–17
  6. de Vries I. Jolanda M., Bernsen Monique R., Lesterhuis W. Joost, Scharenborg Nicole M., Strijk Simon P., Gerritsen Marie-Jeanne P., Ruiter Dirk J., Figdor Carl G., Punt Cornelis J.A., Adema Gosse J., Immunomonitoring Tumor-Specific T Cells in Delayed-Type Hypersensitivity Skin Biopsies After Dendritic Cell Vaccination Correlates With Clinical Outcome, 10.1200/jco.2005.06.478
  7. de Vries I Jolanda M, Lesterhuis W Joost, Barentsz Jelle O, Verdijk Pauline, van Krieken J Han, Boerman Otto C, Oyen Wim J G, Bonenkamp Johannes J, Boezeman Jan B, Adema Gosse J, Bulte Jeff W M, Scheenen Tom W J, Punt Cornelis J A, Heerschap Arend, Figdor Carl G, Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy, 10.1038/nbt1154
  8. Lesterhuis W. J., Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests, 10.1093/annonc/mdl072
  9. Schuler-Thurner Beatrice, Schultz Erwin S., Berger Thomas G., Weinlich Georg, Ebner Susanne, Woerl Petra, Bender Armin, Feuerstein Bernadette, Fritsch Peter O., Romani Nikolaus, Schuler Gerold, Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells, 10.1084/jem.20012100
  10. Figdor Carl G, de Vries I Jolanda M, Lesterhuis W Joost, Melief Cornelis J M, Dendritic cell immunotherapy: mapping the way, 10.1038/nm1039
  11. Van den Eynde Benoît J, van der Bruggen Pierre, T cell defined tumor antigens, 10.1016/s0952-7915(97)80050-7
  12. Bakker Alexander B.H., van der Burg Sjoerd H., Huijbens Richard J.F., Drufhout Jan-Wouter, Melief Cornelis J.M., Adema Gosse J., Figdor Carl G., Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope, 10.1002/(sici)1097-0215(19970127)70:3<302::aid-ijc10>;2-h
  13. Parkhurst MR, Salgaller ML, Southwood S, Robbins PF, Sette A, Rosenberg SA, Kawakami Y (1996) Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues. J Immunol 157:2539–2548
  14. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A, Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, Thompson JA, Thompson JF (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19:3635–3648
  15. Keilholz U, Goey SH, Punt CJ, Proebstle TM, Salzmann R, Scheibenbogen C, Schadendorf D, Liénard D, Enk A, Dummer R, Hantich B, Geueke AM, Eggermont AM (1997) Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. J Clin Oncol 15:2579–2588
  16. Tsuchida Yoshiaki, Therasse Patrick, Response evaluation criteria in solid tumors (RECIST): New guidelines, 10.1002/mpo.1154
  17. de Vries I. Jolanda M., Eggert Andreas A. O., Scharenborg Nicole M., Vissers Joost L. M., Lesterhuis W. Joost, Boerman Otto C., Punt Cornelis J. A., Adema Gosse J., Figdor Carl G., Phenotypical and Functional Characterization of Clinical Grade Dendritic Cells : , 10.1097/00002371-200209000-00007
  18. Thurner Beatrice, Röder Claudia, Dieckmann Detlef, Heuer Marion, Kruse Monika, Glaser Anke, Keikavoussi Petra, Kämpgen Eckhart, Bender Armin, Schuler Gerold, Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application, 10.1016/s0022-1759(98)00208-7
  19. Barker Alexander B. H., Schreurs Marco W. J., Tafazzul Gaalda, De Boer Annemiek J., Kawakami Yutaka, Adema Gosse J., Figdor Carl G., Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1-restricted anti-melanoma CTL line, 10.1002/ijc.2910620118
  20. Cox A., Skipper J, Chen Y, Henderson R., Darrow T., Shabanowitz J, Engelhard V., Hunt D., Slingluff C., Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines, 10.1126/science.7513441
  21. Wölfel Thomas, Schneider Jörg, Zum Büschenfelde Karl-Hermann Meyer, Rammensee Hans-Georg, Rötzschke Olaf, Falk Kirsten, Isolation of naturally processed peptides recognized by cytolytic T lymphocytes (CTL) on human melanoma cells in association with HLA-A2.1, 10.1002/ijc.2910570320
  22. Haanen John B. A. G., Toebes Mireille, Cordaro Tanina A., Wolkers Monika C., Kruisbeek Ada M., Schumacher Ton N. M., Systemic T cell expansion during localized viral infection, 10.1002/(sici)1521-4141(199904)29:04<1168::aid-immu1168>;2-j
  23. Bakker A. B., Melanocyte lineage-specific antigen gp100 is recognized by melanoma- derived tumor-infiltrating lymphocytes, 10.1084/jem.179.3.1005
  24. Karanikas V., Lurquin C., Colau D., van Baren N., De Smet C., Lethe B., Connerotte T., Corbiere V., Demoitie M.-A., Lienard D., Dreno B., Velu T., Boon T., Coulie P. G., Monoclonal Anti-MAGE-3 CTL Responses in Melanoma Patients Displaying Tumor Regression after Vaccination with a Recombinant Canarypox Virus, 10.4049/jimmunol.171.9.4898
  25. Speiser D. E., Baumgaertner P., Voelter V., Devevre E., Barbey C., Rufer N., Romero P., Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen, 10.1073/pnas.0800080105
  26. Coulie P. G., Karanikas V., Colau D., Lurquin C., Landry C., Marchand M., Dorval T., Brichard V., Boon T., A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3, 10.1073/pnas.161260098
  27. Stuge Tor B, Holmes Susan P, Saharan Sahdev, Tuettenberg Andrea, Roederer Mario, Weber Jeffrey S, Lee Peter P, Diversity and Recognition Efficiency of T Cell Responses to Cancer, 10.1371/journal.pmed.0010028
  28. Clay TM, Custer MC, Mckee MD, Parkhurst M, Robbins PF, Kerstann K, Wunderlich J, Rosenberg SA, Nishimura MI (1999) Changes in the fine specificity of gp100(209–217)-reactive T cells in patients following vaccination with a peptide modified at an HLA-A2.1 anchor residue. J Immunol 162:1749–1755