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Myocardial microangiopathy associated with antiphospholipid antibodies.

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Lauwerys, Bernard [UCL] Lambert, Michel [UCL] Vanoverschelde, Jean-Louis [UCL] Cosyns, Jean-Pierre [UCL] Houssiau, Frédéric [UCL]

Myocardial thrombotic microangiopathy is a well described post-mortem finding in patients with the catastrophic antiphospholipid (APL) syndrome. However, it has been only very rarely imaged in living patients. Here, we report two patients with APL antibodies presenting with scintigraphic, electrocardiographic and/or echocardiographic evidence of (sub)acute myocardial ischaemia, despite a normal coronary angiography. Formal proof of a thrombotic microangiopathy was obtained by a kidney biopsy in one patient. We emphasize the value of 99mTc-MIBI (2-methoxy isobutyl isonitrile) exercise stress myocardial scintigraphy for the detection of cardiac microangiopathy associated with the APL syndrome.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2001
Journal information "Lupus" - Vol. 10, no. 2, p. 123-125 (2001)
Peer reviewed yes
Publisher Sage Publications Ltd. (London)
issn 0961-2033
e-issn 1477-0962
Publication status Publié
Affiliations UCL - MD/MNOP - Département de morphologie normale et pathologique
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de cardiologie
UCL - (SLuc) Service de rhumatologie
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
UCL - (SLuc) Centre des cardiopathies congénitales de l'adulte
UCL - (SLuc) Service d'anatomie pathologique
MESH Subject Adult ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome ; Coronary Disease ; Female ; Humans
Keywords Thrombotic microangiopathy ; Antiphospholipid syndrome ; Heart ; Imaging ; Scintigraphy ; SLE
Links
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Bibliographic reference Lauwerys, Bernard ; Lambert, Michel ; Vanoverschelde, Jean-Louis ; Cosyns, Jean-Pierre ; Houssiau, Frédéric. Myocardial microangiopathy associated with antiphospholipid antibodies.. In: Lupus, Vol. 10, no. 2, p. 123-125 (2001)
Permanent URL http://hdl.handle.net/2078.1/8776