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Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome.

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Van den Eynde, Benoît [UCL] Morel, Sandra [UCL]

Upon exposure to IFN-gamma, the standard proteasome is replaced by the immunoproteasome, which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing antigenic peptides presented to CD8(+) T cells. This view has been challenged this year by reports showing that some epitopes, mainly of self origin, are not processed by the immunoproteasome and that mature dendritic cells constitutively express immunoproteasomes and therefore cannot efficiently present such epitopes.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2001
Journal information "Current Opinion in Immunology" - Vol. 13, no. 2, p. 147-153 (2001)
Peer reviewed yes
Publisher Elsevier Science ((United Kingdom) London)
issn 0952-7915
e-issn 1879-0372
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Amino Acid Sequence ; Animals ; Antigen Presentation ; Antigens, Neoplasm - immunology - metabolism ; Cysteine Endopeptidases - immunology - metabolism ; Epitopes, T-Lymphocyte - chemistry - immunology - metabolism ; Gene Expression Profiling ; Humans ; Molecular Sequence Data ; Multienzyme Complexes - immunology - metabolism ; Proteasome Endopeptidase Complex ; Protein Processing, Post-Translational ; Proteins - immunology - metabolism
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Bibliographic reference Van den Eynde, Benoît ; Morel, Sandra. Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome.. In: Current Opinion in Immunology, Vol. 13, no. 2, p. 147-153 (2001)
Permanent URL http://hdl.handle.net/2078.1/8773