User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Transfer of ochratoxin A during lactation: exposure of suckling via the milk of rabbit does fed a naturally-contaminated feed.

Primary tabs

Ferrufino-Guardia, E V Tangni, E K Larondelle, Yvan [UCL] Ponchaut, S.

The transfer of ochratoxin A from the blood to the milk of lactating rabbit does and subsequently the exposure of their sucklings to the mycotoxin were investigated. An effective transfer of ochratoxin A from blood to milk was shown in lactating rabbit does fed a naturally-contaminated diet (10-20 g/kg of body weight/day) throughout a lactation period of 19 days. The ochratoxin A concentrations in plasma and in milk did not significantly change throughout the lactation period with a mean milk/plasma concentration ratio of 0.015. These variables were however significantly correlated (p < 0.05), as were the ingested amounts and milk concentrations. At slaughter, the highest concentration of ochratoxin A accumulated in the body of the rabbit does were found in kidney (1.2 g/kg) followed by liver (158 ng/kg), mammary gland (105 ng/kg) and muscle (38 ng/kg). A linear relationship was found between the ochratoxin A concentrations in milk and in the plasma of the sucklings, indicating an effective transfer of the toxin to the sucklings. If the same is true in humans, the exposure of the breast-fed infant to the toxin, which has been largely reported in the literature, should be a major matter of concern for human health.

Document type Article de périodique (Journal article) – Journal Article
Publication date 2000
Journal information "Food additives and contaminants" - Vol. 17, no. 2, p. 167-75 (2000)
Peer reviewed yes
issn 0265-203X
Publication status Publié
Affiliation UCL - AGRO/BAPA - Département de biologie appliquée et des productions agricoles
MESH Subject Animals ; Animals, Suckling ; Female ; Food Contamination ; Lactation - metabolism ; Milk - metabolism ; Ochratoxins - pharmacokinetics ; Rabbits
Links
  1. Breitholtz-Emanuelsson Anna, Palminger-Hallén Ira, Wohlin Pär Ola, Oskarsson Agneta, Hult Karl, Olsen Monica, Transfer of ochratoxin a from lactating rats to their offspring: A short-term study, 10.1002/nt.2620010605
  2. BREITHOLTZ-EMANUELSSON A., Journal of the Association of Official Analytical Chemists, 76, 842 (1993)
  3. Frisvad Jens C., The connection between the Penicillia and Aspergilli and mycotoxins with special emphasis on misidentified isolates, 10.1007/bf01062373
  4. KOVACS F., Acta Veterinana Hungarica, 43, 393 (1995)
  5. KROGH P., Nordisk Veterinaer Medicin, 29, 402 (1977)
  6. KONTAXI M., Journal of Pharmacology and Experimental Therapeutics, 279, 1507 (1996)
  7. WOOD G. M., Food Additives and Contaminants, 13, 519 (1996)
  8. Mortensen Hans Peder, Hald Benedicte, Larsen Anders Eklundh, Madsen Arne, Ochratoxin A Contaminated Barley for Sows and Piglets : Pig Performance and Residues in Milk and Pigs, 10.1080/00015128309435374
  9. KROGH P., Acta Pathologica et Microbiologica Scandinavica, 246, 1 (1974)
  10. KROGH P., Pathologica et Microbiologica Scandinavica, 84, 215 (1976)
  11. Sharman Matthew, MacDonald Susan, Gilbert John, Automated liquid chromatographic determination of ochratoxin A in cereals and animal products using immunoaffinity column clean-up, 10.1016/0021-9673(92)85373-2
  12. VAN DER MERWE K. J., STEYN P. S., FOURIE L., SCOTT DE B., THERON J. J., Ochratoxin A, a Toxic Metabolite produced by Aspergillus ochraceus Wilh., 10.1038/2051112a0
  13. KROGH P., Pathologica et Microbiologica Scandinavica, Section A, 84, 429 (1976)
  14. LUSKY K., Archiv für Lebensmittelhygiene, 46, 45 (1995)
  15. GALTIER P., Annale de Recherche Vétérinaire, 7, 97 (1977)
  16. Rodgers C. T., Practical aspects of milk collection in the rat, 10.1258/002367795780739980
  17. Schwerdt Gerald, Gekle Michael, Freudinger Ruth, Mildenberger Sigrid, Silbernagl Stefan, Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells, 10.1016/s0005-2736(96)00224-6
  18. PETZINGER E., Mycotox 98: Mycotoxins in Food Chain. Processing and Toxicological Aspects, 580 (1998)
  19. Zimmerli Bernhard, Dick Rudolf, Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data, 10.1016/0378-4347(94)00569-q
  20. Madsen Arne, Hald Benedicte, Lilleh⊘j Eivind, Mortensen Hans Peder, Feeding Experiments with Ochratoxin a Contaminated Barley for Bacon Pigs : 2. Naturally Contaminated Barley given for 6 weeks from 20 kg compared with Normal Barley Supplemented with Crystalline Ochratoxin A and/or Citrinin, 10.1080/00015128209435333
  21. KANE A, CREPPY E, ROSCHENTHALER R, DIRHEIMER G, Changes in urinary and renal tubular enzymes caused by subchronic administration of ochratoxin A in rats, 10.1016/0300-483x(86)90012-0
  22. MICCO C., Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours, 105 (1991)
  23. Micco C., Miraglia M., Brera C., Corneli S., Ambruzzi A., Evaluation of ochratoxin A level in human milk in Italy, 10.1080/02652039509374314
  24. Gareis Manfred, M�rtlbauer Erwin, Bauer Johann, Gedek Brigitte, Bestimmung von Ochratoxin A in Muttermilch, 10.1007/bf01042703
  25. Jonsyn Felixtina E., Maxwell Sheila M., Hendrickse Ralph G., Ochratoxin A and aflatoxins in breast milk samples from Sierra Leone, 10.1007/bf01102890
  26. Galtier P., Alvinerie M., Charpenteau J.L., The pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens, 10.1016/0015-6264(81)90528-9
  27. Krogh P., Elling F., Hald Benedicte, Larsen A.E., Lillehoj E.B., Madsen A., Mortensen H.P., Time-dependent disappearance of ochratoxin a residues in tissues of bacon pigs, 10.1016/0300-483x(76)90025-1
  28. Berndt William O., Hayes A. Wallace, Phillips Richard D., Effects of mycotoxins on renal function: Mycotoxic nephropathy, 10.1038/ki.1980.183
  29. Breitholtz-Emanuelsson Anna, Fuchs Radovan, Hult Karl, Appelgren Lars-Erik, Syntheses of14C-Ochratoxin A and14C-Ochratoxin B and a Comparative Study of their Distribution in Rats Using Whole Body Autoradiography, 10.1111/j.1600-0773.1992.tb00467.x
Bibliographic reference Ferrufino-Guardia, E V ; Tangni, E K ; Larondelle, Yvan ; Ponchaut, S.. Transfer of ochratoxin A during lactation: exposure of suckling via the milk of rabbit does fed a naturally-contaminated feed.. In: Food additives and contaminants, Vol. 17, no. 2, p. 167-75 (2000)
Permanent URL http://hdl.handle.net/2078.1/8509