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A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes.

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Morel, Sandra [UCL] Ooms, Annie [ULg] Van Pel, Aline [UCL] Wölfel, Thomas [III Medizinische Klinik and Poliklinik der Johannes Gutenberg-Universität, Mainz, Germany] Brichard, Vincent G. [Département d’Oncologie Médicale, Institut Curie, Paris, France] van der Bruggen, Pierre [UCL] Van den Eynde, Benoît [UCL] Degiovanni, Gérard [ULg]

We previously described different cytotoxic T lymphocyte (CTL) clones isolated from the blood lymphocytes of a melanoma patient after in vitro stimulation with autologous tumor cells. These CTL clones recognized at least 2 distinct antigens on the melanoma cells. Here, we show that one of them consists of a peptide derived from tyrosinase and presented by HLA-B35. The peptide is 9 amino acids long and has the sequence LPSSADVEF. It can be presented by the 2 major B35 allelic subtypes, B*3501 and B*3503. As HLA-B35 is one of the most frequent HLA-B specificities, being present in about 20% of Caucasian individuals, it may be a useful target for peptide-based immunotherapy of melanoma.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 1999
Journal information "International Journal of Cancer" - Vol. 83, no. 6, p. 755-9 (1999)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 0020-7136
e-issn 1097-0215
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Alleles ; Amino Acid Sequence ; Animals ; B-Lymphocytes ; COS Cells ; Cell Line, Transformed ; Cytotoxicity, Immunologic ; HLA-B35 Antigen - genetics - immunology ; Herpesvirus 4, Human ; Humans ; Melanoma - immunology ; Monophenol Monooxygenase - chemistry - immunology ; Peptide Fragments - chemistry - immunology ; Recombinant Proteins - immunology ; T-Lymphocytes, Cytotoxic - immunology ; Transfection ; Tumor Cells, Cultured
Links
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Bibliographic reference Morel, Sandra ; Ooms, Annie ; Van Pel, Aline ; Wölfel, Thomas ; Brichard, Vincent G. ; et. al. A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes.. In: International Journal of Cancer, Vol. 83, no. 6, p. 755-9 (1999)
Permanent URL http://hdl.handle.net/2078.1/8415