| Authors |
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| Document type |
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Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
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| Abstract |
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OBJECTIVE: A high prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) RNA and E2 antibodies is observable in human immunodeficiency virus type 1 (HIV-1)-infected individuals in Belgium, including intravenous drug users (IDUs), in whom the highest prevalence is observed. A molecular analysis of GBV-C/HGV could give indications on the origin of this infection in IDUs. METHODS: We directly sequenced 7 GBV-C/HGV isolates from this IDU population and performed a phylogenetic analysis comparing the results to known GBV-C/HGV sequences. RESULTS: All 7 isolates were GBV-C/HGV genome type 2. Three were found to be subtype 2a, and 4 belonged to the 2b subtype. No specific clustering was observed for strains obtained from IDUs in Belgium, and they were interspersed between other sequences with long branch lengths. CONCLUSION: Based on our results, it is unlikely that the IDUs were infected recently by GBV-C/HGV from a common ancestral virus. |
| Publication date |
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1999 |
| Journal information |
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"Journal of human virology" - Vol. 2, no. 2, p. 115-20 (1999) |
| Peer reviewed |
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yes |
| issn |
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1090-9508 |
| Publication status |
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Publié |
| Affiliation |
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UCL
- MD/MIGE - Département de microbiologie, d'immunologie et de génétique
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| MESH Subject |
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Adult ; Antibodies, Viral - blood - immunology ; Antigens, Viral - immunology ; Belgium - epidemiology ; Female ; Flaviviridae - classification - genetics ; Genome, Viral ; HIV Infections - complications - virology ; HIV-1 ; Hepatitis, Viral, Human - complications - epidemiology - immunology - virology ; Humans ; Male ; Molecular Sequence Data ; Phylogeny ; Prevalence ; RNA, Viral - blood - genetics ; Sequence Analysis, DNA ; Substance Abuse, Intravenous - complications - virology ; Variation (Genetics) - genetics ; Viral Envelope Proteins - immunology
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