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Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockade.

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Sorrentino, Sajoscha A. Doerries, Carola Manes, Costantina Speer, Thimoteus Dessy, Chantal [UCL] Lobysheva, Irina [UCL] Balligand, Jean-Luc [UCL] Landmesser, Ulf

The aim of this study was to investigate whether nebivolol has added effects on left ventricular (LV) dysfunction and remodeling early after myocardial infarction (MI) beyond its β₁-receptor-blocking properties.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Journal of the american college of cardiology : JACC" - Vol. 57, no. 5, p. 601-611 (2011)
Peer reviewed yes
Publisher Elsevier Science ((United States) [S.l.])
issn 0735-1097
e-issn 1558-3597
Publication status Publié
Affiliations UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
MESH Subject Adrenergic beta-1 Receptor Antagonists - therapeutic use ; Animals ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardial Infarction - complications, drug therapy, physiopathology ; Neovascularization, Physiologic - drug effects, physiology ; Random Allocation ; Rats ; Time Factors ; Ventricular Dysfunction, Left - drug therapy, etiology, physiopathology ; Benzopyrans - therapeutic use ; Cells, Cultured ; Endothelium, Vascular - drug effects, physiology ; Ethanolamines - therapeutic use ; Hematopoietic Stem Cells - drug effects, physiology ; Humans ; Male ; Mice
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Bibliographic reference Sorrentino, Sajoscha A. ; Doerries, Carola ; Manes, Costantina ; Speer, Thimoteus ; Dessy, Chantal ; et. al. Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockade.. In: Journal of the american college of cardiology : JACC, Vol. 57, no. 5, p. 601-611 (2011)
Permanent URL http://hdl.handle.net/2078.1/82369