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Are aromatase inhibitors effective in endometriosis treatment?

Bibliographic reference Colette, Sébastien ; Donnez, Jacques. Are aromatase inhibitors effective in endometriosis treatment?. In: Expert opinion on investigational drugs, Vol. 20, no. 7, p. 917-31 (2011)
Permanent URL http://hdl.handle.net/2078.1/82150
  1. Nisolle Michelle, Donnez Jacques, Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities, 10.1016/s0015-0282(97)00191-x
  2. Ferrero Simone, Venturini Pier L., Ragni Nicola, Camerini Giovanni, Remorgida Valentino, Pharmacological Treatment of Endometriosis : Experience with Aromatase Inhibitors, 10.2165/00003495-200969080-00001
  3. Gupta Sajal, Goldberg Jeffrey M., Aziz Nabil, Goldberg Eric, Krajcir Natalie, Agarwal Ashok, Pathogenic mechanisms in endometriosis-associated infertility, 10.1016/j.fertnstert.2008.02.093
  4. Martin JD, Am Surg, 51, 426 (1985)
  5. Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H, Endometriosis: the pathophysiology as an estrogen-dependent disease, 10.1016/s0960-0760(02)00260-1
  6. Guo Sun-Wei, Emerging drugs for endometriosis, 10.1517/14728210802548360
  7. Vercellini Paolo, Pietropaolo Giuliana, De Giorgi Olga, Pasin Roberta, Chiodini Annalisa, Crosignani Pier Giorgio, Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate, 10.1016/j.fertnstert.2005.03.083
  8. Donnez J., The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach, 10.1093/humupd/8.1.89
  9. Giudice Linda C, Kao Lee C, Endometriosis, 10.1016/s0140-6736(04)17403-5
  10. Mihalyi Attila, Simsa Peter, Mutinda Kyama C, Meuleman Christel, Mwenda Jason M, D’Hooghe Thomas M, Emerging drugs in endometriosis, 10.1517/14728214.11.3.503
  11. Guo S.-W., Recurrence of endometriosis and its control, 10.1093/humupd/dmp007
  12. Simpson ER, Endocr Rev, 15, 342 (1994)
  13. SIMPSON EVAN R., CLYNE COLIN, SPEED CAROLINE, RUBIN GARY, BULUN SERDAR, Tissue-Specific Estrogen Biosynthesis and Metabolism, 10.1111/j.1749-6632.2001.tb04002.x
  14. Bulun S. E., Regulation of Aromatase Expression in Estrogen-Responsive Breast and Uterine Disease: From Bench to Treatment, 10.1124/pr.57.3.6
  15. Agarwal VR, J Clin Endocrinol Metab, 81, 3843 (1996)
  16. Harada N., Utsumi T., Takagi Y., Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis., 10.1073/pnas.90.23.11312
  17. Conley A, Hinshelwood M, Mammalian aromatases, 10.1530/rep.0.1210685
  18. Delvoux Bert, Groothuis Patrick, D'Hooghe Thomas, Kyama Cleophas, Dunselman Gerard, Romano Andrea, Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism, 10.1210/jc.2008-2218
  19. Colette S., Lousse J.C., Defrere S., Curaba M., Heilier J.F., Van Langendonckt A., Mestdagt M., Foidart J.M., Loumaye E., Donnez J., Absence of aromatase protein and mRNA expression in endometriosis, 10.1093/humrep/dep199
  20. Noble LS, J Clin Endocrinol Metab, 81, 174 (1996)
  21. Kitawaki Jo, Noguchi Toshifumi, Amatsu Takashi, Maeda Kazunori, Tsukamoto Katsumi, Yamamoto Takara, Fushiki Shinji, Osawa Yoshio, Honjo Hideo, Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1, 10.1095/biolreprod57.3.514
  22. Noble LS, J Clin Endocrinol Metab, 82, 600 (1997)
  23. Kitawaki Jo, Kusuki Izumi, Koshiba Hisato, Tsukamoto Katsumi, Honjo Hideo, Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis, 10.1159/000052865
  24. Zeitoun Khaled, Takayama Kazuto, Michael M. Dod, Bulun Serdar E., Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Samecis-Acting Element, 10.1210/mend.13.2.0229
  25. Dheenadayalu Kavitha, Mak Ian, Gordts Stephan, Campo Rudi, Higham Jenny, Puttemans Patrick, White John, Christian Mark, Fusi Luca, Brosens Jan, Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis, 10.1016/s0015-0282(02)03324-1
  26. Yang S, J Clin Endocrinol Metab, 87, 2336 (2002)
  27. Ishihara H, Lung Cancer, 79 (2003)
  28. Brosens J., High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome, 10.1093/humrep/deh075
  29. Wolfler M.M., A predictive model for endometriosis, 10.1093/humrep/deh796
  30. Heilier Jean-François, Donnez Jacques, Defrere Sylvie, Van Kerckhove Valérie, Donnez Olivier, Lison Dominique, Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues, 10.1016/j.toxlet.2006.10.005
  31. Heilier Jean-François, Donnez Olivier, Van Kerckhove Valérie, Lison Dominique, Donnez Jacques, Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum, 10.1016/j.fertnstert.2005.10.041
  32. Matsuzaki Sachiko, Canis Michel, Pouly Jean-Luc, Déchelotte Pierre J., Mage Gérard, Analysis of aromatase and 17β-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection, 10.1016/j.fertnstert.2005.08.017
  33. Murakami Koichi, Nomura Kazuhito, Shinohara Kazunori, Kasai Tadayuki, Shozu Makio, Inoue Masaki, Danazol inhibits aromatase activity of endometriosis-derived stromal cells by a competitive mechanism, 10.1016/j.fertnstert.2005.12.074
  34. Dassen H., Punyadeera C., Kamps R., Delvoux B., Van Langendonckt A., Donnez J., Husen B., Thole H., Dunselman G., Groothuis P., Estrogen metabolizing enzymes in endometrium and endometriosis, 10.1093/humrep/dem310
  35. Šmuc Tina, Pucelj Martina Ribič, Šinkovec Jasna, Husen Bettina, Thole Hubert, Rižner Tea Lanišnik, Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis, 10.1080/09513590601152219
  36. Bukulmez Orhan, Hardy Daniel B., Carr Bruce R., Word R. Ann, Mendelson Carole R., Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis, 10.1210/en.2007-0665
  37. Bukulmez Orhan, Hardy Daniel B., Carr Bruce R., Auchus Richard J., Toloubeydokhti Tannaz, Word R. Ann, Mendelson Carole R., Androstenedione Up-Regulation of Endometrial Aromatase Expression via Local Conversion to Estrogen: Potential Relevance to the Pathogenesis of Endometriosis, 10.1210/jc.2008-0248
  38. Izawa Masao, Harada Tasuku, Taniguchi Fuminori, Ohama Yoko, Takenaka Yasuko, Terakawa Naoki, An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells, 10.1016/j.fertnstert.2007.03.078
  39. Kyama Cleophas M., Overbergh Lutgart, Mihalyi Attila, Meuleman Christel, Mwenda Jason M., Mathieu Chantal, D'Hooghe Thomas M., Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis, 10.1016/j.fertnstert.2007.02.057
  40. Toloubeydokhti Tannaz, Qun Pan, Xiaoping Luo, Bukulmez Orhan, Chegini Nasser, RETRACTED: The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs, 10.1177/1933719108324132
  41. Aghajanova L., Hamilton A., Kwintkiewicz J., Vo K.C., Giudice L.C., Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1, 10.1095/biolreprod.108.070300
  42. Attar Erkut, Tokunaga Hideki, Imir Gonca, Yilmaz M. Bertan, Redwine David, Putman Michael, Gurates Bilgin, Attar Rukset, Yaegashi Nobuo, Hales Dale B., Bulun Serdar E., Prostaglandin E2Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis, 10.1210/jc.2008-1180
  43. Morsch Debora M., Carneiro Marcia M., Lecke Sheila B., Araújo Fabiano C., Camargos Aroldo F., Reis Fernando M., Spritzer Poli Mara, c-fos gene and protein expression in pelvic endometriosis: a local marker of estrogen action, 10.1007/s10735-009-9212-7
  44. Šmuc Tina, Hevir Neli, Ribič-Pucelj Martina, Husen Bettina, Thole Hubert, Rižner Tea Lanišnik, Disturbed estrogen and progesterone action in ovarian endometriosis, 10.1016/j.mce.2008.07.020
  45. WANG Qing, ZHAO Hong, XIANG Qing, HAN Shu-min, WANG Ling-yan, XU Bo, JU Hai, Effect of Yikun Neiyi Wan on the Expression of Aromatase P450, COX-2, and ER Related Receptor in Endometrial Cells in Vitro from Patients with Endometriosis, 10.1016/s0254-6272(09)60088-1
  46. Hatok J, Gynecol Endocrinol (2010)
  47. Izawa Masao, Taniguchi Fuminori, Uegaki Takashi, Takai Eri, Iwabe Tomio, Terakawa Naoki, Harada Tasuku, Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues, 10.1016/j.fertnstert.2010.06.024
  48. Shimizu Yutaka, Mita Shizuka, Takeuchi Takashi, Notsu Tatsuto, Mizuguchi Kiyoshi, Kyo Satoru, Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system, 10.1016/j.steroids.2010.08.010
  49. Kitawaki Jo, Kusuki Izumi, Koshiba Hisato, Tsukamoto Katsumi, Fushiki Shinji, Honjo Hideo, Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis, 10.1016/s0015-0282(99)00424-0
  50. Velasco I., Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis, 10.1093/molehr/gal041
  51. Acién Pedro, Velasco Irene, Gutiérrez Mercedes, Martínez-Beltrán Monserrat, Aromatase expression in endometriotic tissues and its relationship to clinical and analytical findings, 10.1016/j.fertnstert.2006.11.188
  52. Hudelist G., Czerwenka K., Keckstein J., Haas C., Fink-Retter A., Gschwantler-Kaulich D., Kubista E., Singer C.F., Expression of Aromatase and Estrogen Sulfotransferase in Eutopic and Ectopic Endometrium: Evidence for Unbalanced Estradiol Production in Endometriosis, 10.1177/1933719107309120
  53. Maia Hugo, Casoy Julio, Correia Tânia, Freitas Luis A., Pimentel Kleber, Athayde Célia, The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis, 10.1080/09513590801890816
  54. Kim Young Ah, Kim Mi Ran, Lee Jae Hoon, Kim Ji Yeon, Hwang Kyung Joo, Kim Han Seong, Lee Eung Soo, Gonadotropin-Releasing Hormone Agonist Reduces Aromatase Cytochrome P450 and Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium of Patients with Endometriosis, 10.1159/000214844
  55. Velasco Irene, Acién Pedro, Campos Adolfo, Acién María Isabel, Ruiz-Maciá Eva, Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression, 10.1016/j.jri.2009.11.004
  56. Holloway Alison C., Stys Katie A., Foster Warren G., DDE-Induced Changes in Aromatase Activity in Endometrial Stromal Cells in Culture, 10.1385/endo:27:1:045
  57. Takemura Yuri, Osuga Yutaka, Yoshino Osamu, Hasegawa Akiko, Hirata Tetsuya, Hirota Yasushi, Nose Emi, Morimoto Chieko, Harada Miyuki, Koga Kaori, Tajima Toshiki, Yano Tetsu, Taketani Yuji, Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells, 10.1210/jc.2006-2486
  58. Purohit A., Fusi L., Brosens J., Woo L.W.L., Potter B.V.L., Reed M.J., Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy, 10.1093/humrep/dem308
  59. Attar E., Aromatase and other steroidogenic genes in endometriosis: translational aspects, 10.1093/humupd/dmi034
  60. Colette S, N Engl J Med, 360, 1911 (2009)
  61. Simpson E.R, Sources of estrogen and their importance, 10.1016/s0960-0760(03)00360-1
  62. Absenger Y., Cyr61, a deregulated gene in endometriosis, 10.1093/molehr/gah053
  63. Konno Ryo, Fujiwara Hiroyuki, Netsu Sachiho, Odagiri Kohei, Shimane Miyuki, Nomura Hitoshi, Suzuki Mitsuaki, Gene Expression Profiling of the Rat Endometriosis Model, 10.1111/j.1600-0897.2007.00507.x
  64. Fabian C. J., The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer : Hormonal agents for treatment and prevention of breast cancer, 10.1111/j.1742-1241.2007.01587.x
  65. Howell A, ATAC trial update, 10.1016/s0140-6736(05)74803-0
  66. Bonneterre J., Thürlimann B., Robertson J.F. R., Krzakowski M., Mauriac L., Koralewski P., Vergote I., Webster A., Steinberg M., von Euler M., Anastrozole Versus Tamoxifen as First-Line Therapy for Advanced Breast Cancer in 668 Postmenopausal Women: Results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability Study, 10.1200/jco.2000.18.22.3748
  67. Nabholtz J.M., Buzdar A., Pollak M., Harwin W., Burton G., Mangalik A., Steinberg M., Webster A., von Euler M., Anastrozole Is Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer in Postmenopausal Women: Results of a North American Multicenter Randomized Trial, 10.1200/jco.2000.18.22.3758
  68. Takayama K, Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor, 10.1016/s0015-0282(98)00022-3
  69. D'Hooghe T.M., Kyama C.M., Chai D., Fassbender A., Vodolazkaia A., Bokor A., Mwenda J.M., Nonhuman Primate Models for Translational Research in Endometriosis, 10.1177/1933719108322430
  70. Yano S, Arzneimittelforschung, 46, 192 (1996)
  71. Altintas Devrim, Kokcu Arif, Kandemir Bedri, Tosun Migraci, Cetinkaya Mehmet B., Comparison of the effects of raloxifene and anastrozole on experimental endometriosis, 10.1016/j.ejogrb.2010.02.004
  72. Ceyhan ST, Eur J Obstet Gynecol Reprod Biol (2010)
  73. Oner G., Ozcelik B., Ozgun M. T., Serin I. S., Ozturk F., Basbug M., The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model, 10.1093/humrep/deq016
  74. Fang Zongjuan, Yang Sijun, Gurates Bilgin, Tamura Mitsutoshi, Simpson Evan, Evans Dean, Bulun Serdar E., Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue, 10.1210/jcem.87.7.8683
  75. Fechner Sabine, Husen Bettina, Thole Hubert, Schmidt Markus, Gashaw Isabella, Kimmig Rainer, Winterhager Elke, Grümmer Ruth, Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue, 10.1016/j.fertnstert.2006.11.153
  76. Bilotas Mariela, Meresman Gabriela, Stella Inés, Sueldo Carlos, Barañao Rosa Inés, Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis, 10.1016/j.fertnstert.2009.08.058
  77. Erbayraktar S, J Reprod Med, 47, 955 (2002)
  78. Razzi Sandro, Fava Antonio, Sartini Annalisa, Simone Simona, Cobellis Luigi, Petraglia Felice, Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman, 10.1046/j.1471-0528.2003.00038.x
  79. Fatemi HM, Al-Turki HA, Papanikolaou EG, Kosmas L, De Sutter P, Devroey P, Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor, 10.1016/s1472-6483(10)61140-6
  80. Mousa Noha A., Bedaiwy Mohamed A., Casper Robert F., Aromatase Inhibitors in the Treatment of Severe Endometriosis : , 10.1097/01.aog.0000265807.19397.6d
  81. Bohrer Justin, Chen Chi Chiung Grace, Falcone Tommaso, Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor, 10.1016/j.fertnstert.2008.03.040
  82. Sasson Isaac E., Taylor Hugh S., Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman, 10.1016/j.fertnstert.2009.05.071
  83. Shippen Eugene R, West William J, Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor, 10.1016/j.fertnstert.2003.11.027
  84. Takai N, Clin Exp Obstet Gynecol, 35, 295 (2008)
  85. Verma Alka, Konje Justin C., Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients, 10.1016/j.ejogrb.2008.12.002
  86. Ferrero S, Gynecol Endocrinol (2010)
  87. Gurates Bilgin, Parmaksiz Cem, Kilic Gokhan, Celik Husnu, Kumru Selahattin, Simsek Mehmet, Treatment of symptomatic uterine leiomyoma with letrozole, 10.1016/s1472-6483(10)60246-5
  88. Parsanezhad Mohammad Ebrahim, Azmoon Mina, Alborzi Saeed, Rajaeefard Abdoreza, Zarei Afsun, Kazerooni Talieh, Frank Vivian, Schmidt Ernst Hienrich, A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status, 10.1016/j.fertnstert.2008.09.064
  89. Ailawadi Radhika K, Jobanputra Smeeta, Kataria Meera, Gurates Bilgin, Bulun Serdar E, Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study, 10.1016/j.fertnstert.2003.09.029
  90. Remorgida Valentino, Abbamonte Helena Luiza, Ragni Nicola, Fulcheri Ezio, Ferrero Simone, Letrozole and norethisterone acetate in rectovaginal endometriosis, 10.1016/j.fertnstert.2006.12.027
  91. Ferrero S., Camerini G., Seracchioli R., Ragni N., Venturini P.L., Remorgida V., Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis, 10.1093/humrep/dep302
  92. Ferrero Simone, Camerini Giovanni, Ragni Nicola, Venturini Pier L., Biscaldi Ennio, Seracchioli Renato, Remorgida Valentino, Letrozole and norethisterone acetate in colorectal endometriosis, 10.1016/j.ejogrb.2010.02.023
  93. Evers Johannes L.H., Dunselman Gerard A.J., Groothuis Patrick, Now you see them, now you don’t, 10.1016/j.fertnstert.2005.01.122
  94. Amsterdam Lisa L., Gentry William, Jobanputra Smeta, Wolf Michael, Rubin Stephen D., Bulun Serdar E., Anastrazole and oral contraceptives: a novel treatment for endometriosis, 10.1016/j.fertnstert.2005.02.018
  95. REMORGIDA Valentino, ABBAMONTE Luiza Helena, RAGNI Nicola, FULCHERI Ezio, FERRERO Simone, Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis, 10.1111/j.1479-828x.2007.00722.x
  96. Lossl Kristine, Loft Anne, Freiesleben Nina L.C., Bangsbøll Susanne, Andersen Claus Yding, Pedersen Anette T., Hartwell Dorthe, Andersen Anders Nyboe, Combined down-regulation by aromatase inhibitor and GnRH-agonist in IVF patients with endometriomas—A pilot study, 10.1016/j.ejogrb.2009.02.001
  97. HEFLER L, GRIMM C, VANTROTSENBURG M, NAGELE F, Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study, 10.1016/j.fertnstert.2005.04.059
  98. Soysal S., The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial, 10.1093/humrep/deh035
  99. Alborzi S, Arch Gynecol Obstet (2010)
  100. Roghaei MA, IJFS, 4, 67 (2010)
  101. Patwardhan S, Nawathe A, Yates D, Harrison GR, Khan KS, Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis, 10.1111/j.1471-0528.2008.01740.x