User menu

Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery

Bibliographic reference Driessens, Gregory ; Nuttin, Lise ; Gras, Alain ; Maetens, Julie ; Mievis, Stephane ; et. al. Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery. In: Cancer Immunology, Immunotherapy, Vol. 60, no. 2, p. 273-281 (2011)
Permanent URL
  1. Andersen Mads Hald, Sørensen Rikke Bæk, Schrama David, Svane Inge Marie, Becker Jürgen C., thor Straten Per, Cancer treatment: the combination of vaccination with other therapies, 10.1007/s00262-008-0480-y
  2. Driessens Gregory, Hamdane Malika, Cool Vincent, Velu Thierry, Bruyns Catherine, Highly Successful Therapeutic Vaccinations Combining Dendritic Cells and Tumor Cells Secreting Granulocyte Macrophage Colony-stimulating Factor, 10.1158/0008-5472.can-04-0774
  3. Driessens Gregory, Hoffmann Paul, Pouwels Michael, Zlotta Alexandre, Schulman Claude, Velu Thierry, Bruyns Catherine A., Synergy Between Dendritic Cells and GM–CSF-secreting Tumor Cells for the Treatment of a Murine Renal Cell Carcinoma : , 10.1097/cji.0b013e3181920275
  4. Driessens Gregory, Gordower Laurence, Nuttin Lise, Stordeur Patrick, Blocklet Didier, Egrise Dominique, Velu Thierry, Bruyns Catherine, Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration, 10.1007/s00262-008-0500-y
  5. Steinman Ralph M., Banchereau Jacques, Taking dendritic cells into medicine, 10.1038/nature06175
  6. Banchereau Jacques, Palucka A. Karolina, Dendritic cells as therapeutic vaccines against cancer, 10.1038/nri1592
  7. Albert Matthew L., Sauter Birthe, Bhardwaj Nina, 10.1038/32183
  8. Hoffmann TK, Meidenbauer N, Dworacki G, Kanaya H, Whiteside TL (2000) Generation of tumor specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells. Cancer Res 60:3542–3549
  9. Sauter B., Albert M. L., Francisco L., Larsson M., Somersan S., Bhardwaj N., Consequences of Cell Death: Exposure to Necrotic Tumor Cells, but Not Primary Tissue Cells or Apoptotic Cells, Induces the Maturation of Immunostimulatory Dendritic Cells, 10.1084/jem.191.3.423
  10. Steinman R. M., The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells, 10.1084/jem.191.3.411
  11. Milas L, Hunter NR, Mason KA, Kurdoglu B, Peters LJ (1994) Enhancement of tumor radioresponse of a murine mammary-carcinoma by paclitaxel. Cancer Res 54:3506–3510
  12. Dewey William C., Ling Clifton C., Meyn Raymond E., Radiation-induced apoptosis: Relevance to radiotherapy, 10.1016/0360-3016(95)00214-8
  13. Nikitina Ekaterina Yu., Gabrilovich Dmitry I., Combination of ?-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: Approach to treatment of advanced stage cancer, 10.1002/1097-0215(20011215)94:6<825::aid-ijc1545>;2-5
  14. Teitz-Tennenbaum S, Li Q, Rynkiewicz S, Ito F, Davis M, McGinn C, Chang AE (2003) Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration. Cancer Res 63:8466–8475
  15. Dranoff Glenn, GM-CSF-based cancer vaccines, 10.1034/j.1600-065x.2002.18813.x
  16. Nemunaitis J., Sterman D., Jablons D., Smith J. W., Fox B., Maples P., Hamilton S., Borellini F., Lin A., Morali S., Hege K., Granulocyte-Macrophage Colony-Stimulating Factor Gene-Modified Autologous Tumor Vaccines in Non-Small-Cell Lung Cancer, 10.1093/jnci/djh028
  17. Huang A., Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D, Levitsky H, Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens, 10.1126/science.7513904
  18. Vuylsteke Ronald J. C. L. M., Molenkamp Barbara G., Gietema Hester A., van Leeuwen Paul A. M., Wijnands Pepijn G. J. T. B., Vos Wim, van Diest Paul J., Scheper Rik J., Meijer Sybren, de Gruijl Tanja D., Local Administration of Granulocyte/Macrophage Colony-stimulating Factor Increases the Number and Activation State of Dendritic Cells in the Sentinel Lymph Node of Early-Stage Melanoma, 10.1158/0008-5472.can-03-3251
  19. Perales Miguel-Angel, Yuan Jianda, Powel Sarah, Gallardo Humilidad F, Rasalan Teresa S, Gonzalez Christina, Manukian Gregor, Wang Jian, Zhang Yan, Chapman Paul B, Krown Susan E, Livingston Philip O, Ejadi Samuel, Panageas Katherine S, Engelhorn Manuel E, Terzulli Stephanie L, Houghton Alan N, Wolchok Jedd D, Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma, 10.1038/mt.2008.196
  20. Egilmez NK, Jong YS, Sabel MS, Jacob JS, Mathiowitz E, Bankert RB (2000) In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: Induction of tumor regression and potent antitumor immunity. Cancer Res 60:3832–3837
  21. Pan Ping-Ying, Li Yu, Li Qingsheng, Gu Pedi, Martinet Olivier, Thung Swan, Chen Shu-Hsia, In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery, 10.1007/s00262-003-0417-4
  22. Daya S., Berns K. I., Gene Therapy Using Adeno-Associated Virus Vectors, 10.1128/cmr.00008-08
  23. Srivastava Arun, Adeno-associated virus-mediated gene transfer, 10.1002/jcb.21819
  24. Wang Y, Liu SL, Li CY, Yuan F (2005) A novel method for viral gene delivery in solid tumors. Cancer Res 65:7541–7545
  25. Escobar-Chávez JJ, López-Cervantes M, Naïk A et al (2006) Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm Pharm Sci 9:339–358
  26. Aarntzen E. H. J. G., Figdor C. G., Adema G. J., Punt C. J. A., de Vries I. J. M., Dendritic cell vaccination and immune monitoring, 10.1007/s00262-008-0553-y
  27. den Brok Martijn H. M. G. M., Sutmuller Roger P. M., van der Voort Robbert, Bennink Erik J., Figdor Carl G., Ruers Theo J. M., Adema Gosse J., In SituTumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity, 10.1158/0008-5472.can-03-3949
  28. Takeshima T., Chamoto K., Wakita D., Ohkuri T., Togashi Y., Shirato H., Kitamura H., Nishimura T., Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy, 10.1158/0008-5472.can-09-2982
  29. Prise Kevin M., O'Sullivan Joe M., Radiation-induced bystander signalling in cancer therapy, 10.1038/nrc2603
  30. Lim Dae-Seog, Kim Jeong-Hwan, Lee Dong-Seong, Yoon Cheol-Hee, Bae Yong-Soo, DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors, 10.1007/s00262-007-0325-0
  31. Kleindienst P., Brocker T., Endogenous Dendritic Cells Are Required for Amplification of T Cell Responses Induced by Dendritic Cell Vaccines In Vivo, 10.4049/jimmunol.170.6.2817
  32. Hillman Gilda G, Slos Philippe, Wang Yu, Wright Jennifer L, Layer Andrey, De Meyer Micael, Yudelev Mark, Che Mingxin, Forman Jeffrey D, Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma, 10.1038/sj.cgt.7700656
  33. Xia Dajing, Moyana Terence, Xiang Jim, Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors, 10.1038/
  34. Hacker Ulrich T., Wingenfeld Lisa, Kofler David M., Schuhmann Natascha K., Lutz Sandra, Herold Tobias, King Susan B.S., Gerner Franz M., Perabo Luca, Rabinowitz Joseph, McCarty Douglas M., Samulski Richard J., Hallek Michael, Büning Hildegard, Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency, 10.1002/jgm.782
  35. Huszthy Peter C., Svendsen Agnete, Wilson James M., Kotin Robert M., Lønning Per Eystein, Bjerkvig Rolf, Hoover Frank, Widespread Dispersion of Adeno-Associated Virus Serotype 1 and Adeno-Associated Virus Serotype 6 Vectors in the Rat Central Nervous System and in Human Glioblastoma Multiforme Xenografts, 10.1089/hum.2005.16.381
  36. Shi Fu-Shun, Weber Sharon, Gan Jacek, Rakhmilevich Alexander L, Mahvi David M, Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF, 10.1038/sj.cgt.7700012
  37. Kurane Shuji, Arca Marjorie T., Aruga Atsushi, Krinock Robert A., Krauss John C., Chang Alfred E., Cytokines as an adjuvant to tumor vaccines: Efficacy of local methods of delivery, 10.1007/bf02305540
  38. Wallenfriedman Margaret A., Conrad John A., DelaBarre Lance, Graupman Patrick C., Lee Gina, Garwood Michael, Gregerson Dale S., Jean Walter C., Hall Walter A., Low Walter C., Effects of continuous localized infusion of granulocyte—macrophage colony—stimulating factor and inoculations of irradiated glioma cells on tumor regression, 10.3171/jns.1999.90.6.1064
  39. Daro E., Pulendran B., Brasel K., Teepe M., Pettit D., Lynch D. H., Vremec D., Robb L., Shortman K., McKenna H. J., Maliszewski C. R., Maraskovsky E., Polyethylene Glycol-Modified GM-CSF Expands CD11bhighCD11chigh But Not CD11blowCD11chigh Murine Dendritic Cells In Vivo: A Comparative Analysis with Flt3 Ligand, 10.4049/jimmunol.165.1.49
  40. STRAPPE P, HAMPTON D, CACHONGONZALEZ B, FAWCETT J, LEVER A, Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system, 10.1016/j.ejpb.2005.06.006
  41. Tong YZ, Song WR, Crystal RG (2001) Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors. Cancer Res 61:7530–7535
  42. Mulé James J., Dendritic Cell-Based Vaccines for Pancreatic Cancer and Melanoma, 10.1111/j.1749-6632.2009.04936.x
  43. Palucka Karolina, Ueno Hideki, Fay Joseph, Banchereau Jacques, Harnessing Dendritic Cells to Generate Cancer Vaccines, 10.1111/j.1749-6632.2009.05000.x
  44. Gupta R, Emens LA (2010) GM-CSF-secreting vaccines for solid tumors: moving forward. Discov Med 10:52–60