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Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.

Bibliographic reference Roger, B ; Papin, J ; Vacher, P ; Raoux, M ; Mulot, A ; et. al. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.. In: Diabetologia : clinical and experimental diabetes and metabolism, Vol. 54, no. 2, p. 390-402 (2011)
Permanent URL http://hdl.handle.net/2078.1/76118
  1. MacDonald P. E., Rorsman P., The Ins and Outs of Secretion from Pancreatic  -Cells: Control of Single-Vesicle Exo- and Endocytosis, 10.1152/physiol.00047.2006
  2. Unger R. H., Glucagon physiology and pathophysiology in the light of new advances, 10.1007/bf00281991
  3. Poitout Vincent, Robertson R. Paul, Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction, 10.1210/er.2007-0023
  4. Højberg P. V., Vilsbøll T., Rabøl R., Knop F. K., Bache M., Krarup T., Holst J. J., Madsbad S., Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes, 10.1007/s00125-008-1195-5
  5. Knop Filip K., Vilsbøll Tina, Højberg Patricia V., Larsen Steen, Madsbad Sten, Vølund Aage, Holst Jens J., Krarup Thure, Reduced Incretin Effect in Type 2 Diabetes : Cause or Consequence of the Diabetic State?, 10.2337/db07-0100
  6. Holst J. J., The Physiology of Glucagon-like Peptide 1, 10.1152/physrev.00034.2006
  7. Buteau J., Foisy S., Joly E., Prentki M., Glucagon-Like Peptide 1 Induces Pancreatic  -Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor, 10.2337/diabetes.52.1.124
  8. MacDonald Patrick E., Wang Xiaolin, Xia Fuzhen, El-kholy Wasim, Targonsky Elisha D., Tsushima Robert G., Wheeler Michael B., Antagonism of Rat β-Cell Voltage-dependent K+Currents by Exendin 4 Requires Dual Activation of the cAMP/Protein Kinase A and Phosphatidylinositol 3-Kinase Signaling Pathways, 10.1074/jbc.m307612200
  9. Holz George G., Kang Guoxin, Harbeck Mark, Roe Michael W., Chepurny Oleg G., Cell physiology of cAMP sensor Epac : cAMP sensor Epac in cell physiology, 10.1113/jphysiol.2006.119644
  10. Gromada J., Dissing S., Bokvist K., Renstrom E., Frokjaer-Jensen J., Wulff B. S., Rorsman P., Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization, 10.2337/diabetes.44.7.767
  11. TSUBOI Takashi, SILVA XAVIER Gabriela da, HOLZ George G., JOUAVILLE Laurence S., THOMAS Andrew P., RUTTER Guy A., Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells, 10.1042/bj20021288
  12. Lang Jochen, Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion, 10.1046/j.1432-1327.1999.00043.x
  13. Henquin J. C., Regulation of insulin secretion: a matter of phase control and amplitude modulation, 10.1007/s00125-009-1314-y
  14. Kim S.-J., Nian C., Widenmaier S., McIntosh C. H. S., Glucose-Dependent Insulinotropic Polypeptide-Mediated Up-Regulation of  -Cell Antiapoptotic Bcl-2 Gene Expression Is Coordinated by Cyclic AMP (cAMP) Response Element Binding Protein (CREB) and cAMP-Responsive CREB Coactivator 2, 10.1128/mcb.00325-07
  15. Khaldi M. Z., Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose, 10.1152/ajpendo.00426.2003
  16. Dubois Mathilde, Vacher Pierre, Roger Benoı̂t, Huyghe Deborah, Vandewalle Brigitte, Kerr-Conte Julie, Pattou François, Moustaïd-Moussa Naima, Lang Jochen, Glucotoxicity Inhibits Late Steps of Insulin Exocytosis, 10.1210/en.2006-1022
  17. Lajus Sophie, Vacher Pierre, Huber Denise, Dubois Mathilde, Benassy Marie-Noëlle, Ushkaryov Yuri, Lang Jochen, α-Latrotoxin Induces Exocytosis by Inhibition of Voltage-dependent K+Channels and by Stimulation of L-type Ca2+Channels via Latrophilin in β-Cells, 10.1074/jbc.m510528200
  18. Dubois M., Kerr-Conte J., Gmyr V., Bouckenooghe T., Muharram G., D’Herbomez M., Martin-Ponthieu A., Vantyghem M. C., Vandewalle B., Pattou F., Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration, 10.1007/s00125-004-1347-1
  19. Bensellam M., Van Lommel L., Overbergh L., Schuit F. C., Jonas J. C., Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations, 10.1007/s00125-008-1245-z
  20. Patton Chris, Thompson Stuart, Epel David, Some precautions in using chelators to buffer metals in biological solutions, 10.1016/j.ceca.2003.10.006
  21. Dyachok Oleg, Idevall-Hagren Olof, Sågetorp Jenny, Tian Geng, Wuttke Anne, Arrieumerlou Cécile, Akusjärvi Göran, Gylfe Erik, Tengholm Anders, Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion, 10.1016/j.cmet.2008.06.003
  22. Siegel E G, Wollheim C B, Kikuchi M, Renold A E, Sharp G W, Dependency of cyclic AMP-induced insulin release on intra- and extracellular calcium in rat islets of Langerhans., 10.1172/jci109665
  23. Roche Enrique, Assimacopoulos-Jeannet Françoise, Witters Lee A., Perruchoud Blaise, Yaney Gordon, Corkey Barbara, Asfari Maryam, Prentki Marc, Induction by Glucose of Genes Coding for Glycolytic Enzymes in a Pancreatic β-Cell Line (INS-1), 10.1074/jbc.272.5.3091
  24. Regard JB, Kataoka H, Cano DA et al (2007) Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 117:4034–4043
  25. Abderrahmani Amar, Cheviet Séverine, Ferdaoussi Mourad, Coppola Thierry, Waeber Gérard, Regazzi Romano, ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis, 10.1038/sj.emboj.7601008
  26. Tsuboi T., Ravier M. A., Parton L. E., Rutter G. A., Sustained Exposure to High Glucose Concentrations Modifies Glucose Signaling and the Mechanics of Secretory Vesicle Fusion in Primary Rat Pancreatic  -Cells, 10.2337/diabetes.55.04.06.db05-1577
  27. Olofsson C. S., Collins S., Bengtsson M., Eliasson L., Salehi A., Shimomura K., Tarasov A., Holm C., Ashcroft F., Rorsman P., Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane, 10.2337/db06-1150
  28. Renström E., Eliasson Lena, Rorsman P., Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells, 10.1111/j.1469-7793.1997.105bl.x
  29. Delmeire D., Flamez D., Hinke S. A., Cali J. J., Pipeleers D., Schuit F., Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1, 10.1007/s00125-003-1203-8
  30. Fridlyand L. E., Harbeck M. C., Roe M. W., Philipson L. H., Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic -cell: a computational approach, 10.1152/ajpcell.00555.2006
  31. Waddleton Deena, Wu Weizhen, Feng Yue, Thompson Chris, Wu Michael, Zhou Yun-Ping, Howard Andrew, Thornberry Nancy, Li Jing, Mancini Joseph A., Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets, 10.1016/j.bcp.2008.07.025
  32. Choi Young Hun, Park Sunhee, Hockman Steven, Zmuda-Trzebiatowska Emilia, Svennelid Fredrik, Haluzik Martin, Gavrilova Oksana, Ahmad Faiyaz, Pepin Laurent, Napolitano Maria, Taira Masato, Sundler Frank, Stenson Holst Lena, Degerman Eva, Manganiello Vincent C., Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice, 10.1172/jci24867
  33. Kutlu Burak, Burdick David, Baxter David, Rasschaert Joanne, Flamez Daisy, Eizirik Decio L, Welsh Nils, Goodman Nathan, Hood Leroy, Detailed transcriptome atlas of the pancreatic beta cell, 10.1186/1755-8794-2-3
  34. Willoughby D., Cooper D. M. F., Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains, 10.1152/physrev.00049.2006
  35. Masada Nanako, Ciruela Antonio, MacDougall David A., Cooper Dermot M. F., Distinct Mechanisms of Regulation by Ca2+/Calmodulin of Type 1 and 8 Adenylyl Cyclases Support Their Different Physiological Roles, 10.1074/jbc.m807359200
  36. Takeshita Shigeru, Moritani Maki, Kunika Kiyoshi, Inoue Hiroshi, Itakura Mitsuo, Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice, 10.1007/s00335-005-0130-z
  37. de Mooij-van Malsen Annetrude (J.G.), van Lith Hein A., Oppelaar Hugo, Hendriks Judith, de Wit Marina, Kostrzewa Elżbieta, Breen Gerome, Collier David A., Olivier Berend, Kas Martien J., Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder, 10.1016/j.biopsych.2009.06.016
  38. Xu G., Kaneto H., Laybutt D. R., Duvivier-Kali V. F., Trivedi N., Suzuma K., King G. L., Weir G. C., Bonner-Weir S., Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes, 10.2337/db06-1033
  39. Zhou J., Livak M. F. A., Bernier M., Muller D. C., Carlson O. D., Elahi D., Maudsley S., Egan J. M., Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets, 10.1152/ajpendo.00070.2007
  40. Briaud I., Lingohr M. K., Dickson L. M., Wrede C. E., Rhodes C. J., Differential Activation Mechanisms of Erk-1/2 and p70S6K by Glucose in Pancreatic  -Cells, 10.2337/diabetes.52.4.974
  41. Costes S., Broca C., Bertrand G., Lajoix A.-D., Bataille D., Bockaert J., Dalle S., ERK1/2 Control Phosphorylation and Protein Level of cAMP-Responsive Element-Binding Protein: A Key Role in Glucose-Mediated Pancreatic  -Cell Survival, 10.2337/db05-1618
  42. Klinger Sonia, Poussin Carine, Debril Marie-Bernard, Dolci Wanda, Halban Philippe A., Thorens Bernard, Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14, 10.2337/db07-1414
  43. Jansson D., Ng A. C.-H., Fu A., Depatie C., Al Azzabi M., Screaton R. A., Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2, 10.1073/pnas.0800796105
  44. Inada A., Hamamoto Y., Tsuura Y., Miyazaki J.-i., Toyokuni S., Ihara Y., Nagai K., Yamada Y., Bonner-Weir S., Seino Y., Overexpression of Inducible Cyclic AMP Early Repressor Inhibits Transactivation of Genes and Cell Proliferation in Pancreatic   Cells, 10.1128/mcb.24.7.2831-2841.2004
  45. Faruque O. M., Le-Nguyen D., Lajoix A.-D., Vives E., Petit P., Bataille D., Hani E.-H., Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring, 10.1152/ajpcell.00216.2008
  46. Ramos Lavoisier S., Zippin Jonathan Hale, Kamenetsky Margarita, Buck Jochen, Levin Lonny R., Glucose and GLP-1 Stimulate cAMP Production via Distinct Adenylyl Cyclases in INS-1E Insulinoma Cells, 10.1085/jgp.200810044
  47. Moulder K. L., Jiang X., Chang C., Taylor A. A., Benz A. M., Conti A. C., Muglia L. J., Mennerick S., A Specific Role for Ca2+-Dependent Adenylyl Cyclases in Recovery from Adaptive Presynaptic Silencing, 10.1523/jneurosci.5317-07.2008
  48. Saxena Richa, Hivert Marie-France, Langenberg Claudia, Tanaka Toshiko, Pankow James S, Vollenweider Peter, Lyssenko Valeriya, Bouatia-Naji Nabila, Dupuis Josée, Jackson Anne U, Kao W H Linda, Li Man, Glazer Nicole L, Manning Alisa K, Luan Jian'an, Stringham Heather M, Prokopenko Inga, Johnson Toby, Grarup Niels, Boesgaard Trine W, Lecoeur Cécile, Shrader Peter, O'Connell Jeffrey, Ingelsson Erik, Couper David J, Rice Kenneth, Song Kijoung, Andreasen Camilla H, Dina Christian, Köttgen Anna, Le Bacquer Olivier, Pattou François, Taneera Jalal, Steinthorsdottir Valgerdur, Rybin Denis, Ardlie Kristin, Sampson Michael, Qi Lu, van Hoek Mandy, Weedon Michael N, Aulchenko Yurii S, Voight Benjamin F, Grallert Harald, Balkau Beverley, Bergman Richard N, Bielinski Suzette J, Bonnefond Amelie, Bonnycastle Lori L, Borch-Johnsen Knut, Böttcher Yvonne, Brunner Eric, Buchanan Thomas A, Bumpstead Suzannah J, Cavalcanti-Proença Christine, Charpentier Guillaume, Chen Yii-Der Ida, Chines Peter S, Collins Francis S, Cornelis Marilyn, J Crawford Gabriel, Delplanque Jerome, Doney Alex, Egan Josephine M, Erdos Michael R, Firmann Mathieu, Forouhi Nita G, Fox Caroline S, Goodarzi Mark O, Graessler Jürgen, Hingorani Aroon, Isomaa Bo, Jørgensen Torben, Kivimaki Mika, Kovacs Peter, Krohn Knut, Kumari Meena, Lauritzen Torsten, Lévy-Marchal Claire, Mayor Vladimir, McAteer Jarred B, Meyre David, Mitchell Braxton D, Mohlke Karen L, Morken Mario A, Narisu Narisu, Palmer Colin N A, Pakyz Ruth, Pascoe Laura, Payne Felicity, Pearson Daniel, Rathmann Wolfgang, Sandbaek Annelli, Sayer Avan Aihie, Scott Laura J, Sharp Stephen J, Sijbrands Eric, Singleton Andrew, Siscovick David S, Smith Nicholas L, Sparsø Thomas, Swift Amy J, Syddall Holly, Thorleifsson Gudmar, Tönjes Anke, Tuomi Tiinamaija, Tuomilehto Jaakko, Valle Timo T, Waeber Gérard, Walley Andrew, Waterworth Dawn M, Zeggini Eleftheria, Zhao Jing Hua, Illig Thomas, Wichmann H Erich, Wilson James F, van Duijn Cornelia, Hu Frank B, Morris Andrew D, Frayling Timothy M, Hattersley Andrew T, Thorsteinsdottir Unnur, Stefansson Kari, Nilsson Peter, Syvänen Ann-Christine, Shuldiner Alan R, Walker Mark, Bornstein Stefan R, Schwarz Peter, Williams Gordon H, Nathan David M, Kuusisto Johanna, Laakso Markku, Cooper Cyrus, Marmot Michael, Ferrucci Luigi, Mooser Vincent, Stumvoll Michael, Loos Ruth J F, Altshuler David, Psaty Bruce M, Rotter Jerome I, Boerwinkle Eric, Hansen Torben, Pedersen Oluf, Florez Jose C, McCarthy Mark I, Boehnke Michael, Barroso Inês, Sladek Robert, Froguel Philippe, Meigs James B, Groop Leif, Wareham Nicholas J, Watanabe Richard M, Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge, 10.1038/ng.521
  49. Dupuis Josée, Langenberg Claudia, Prokopenko Inga, Saxena Richa, Soranzo Nicole, Jackson Anne U, Wheeler Eleanor, Glazer Nicole L, Bouatia-Naji Nabila, Gloyn Anna L, Lindgren Cecilia M, Mägi Reedik, Morris Andrew P, Randall Joshua, Johnson Toby, Elliott Paul, Rybin Denis, Thorleifsson Gudmar, Steinthorsdottir Valgerdur, Henneman Peter, Grallert Harald, Dehghan Abbas, Hottenga Jouke Jan, Franklin Christopher S, Navarro Pau, Song Kijoung, Goel Anuj, Perry John R B, Egan Josephine M, Lajunen Taina, Grarup Niels, Sparsø Thomas, Doney Alex, Voight Benjamin F, Stringham Heather M, Li Man, Kanoni Stavroula, Shrader Peter, Cavalcanti-Proença Christine, Kumari Meena, Qi Lu, Timpson Nicholas J, Gieger Christian, Zabena Carina, Rocheleau Ghislain, Ingelsson Erik, An Ping, O'Connell Jeffrey, Luan Jian'an, Elliott Amanda, McCarroll Steven A, Payne Felicity, Roccasecca Rosa Maria, Pattou François, Sethupathy Praveen, Ardlie Kristin, Ariyurek Yavuz, Balkau Beverley, Barter Philip, Beilby John P, Ben-Shlomo Yoav, Benediktsson Rafn, Bennett Amanda J, Bergmann Sven, Bochud Murielle, Boerwinkle Eric, Bonnefond Amélie, Bonnycastle Lori L, Borch-Johnsen Knut, Böttcher Yvonne, Brunner Eric, Bumpstead Suzannah J, Charpentier Guillaume, Chen Yii-Der Ida, Chines Peter, Clarke Robert, Coin Lachlan J M, Cooper Matthew N, Cornelis Marilyn, Crawford Gabe, Crisponi Laura, Day Ian N M, de Geus Eco J C, Delplanque Jerome, Dina Christian, Erdos Michael R, Fedson Annette C, Fischer-Rosinsky Antje, Forouhi Nita G, Fox Caroline S, Frants Rune, Franzosi Maria Grazia, Galan Pilar, Goodarzi Mark O, Graessler Jürgen, Groves Christopher J, Grundy Scott, Gwilliam Rhian, Gyllensten Ulf, Hadjadj Samy, Hallmans Göran, Hammond Naomi, Han Xijing, Hartikainen Anna-Liisa, Hassanali Neelam, Hayward Caroline, Heath Simon C, Hercberg Serge, Herder Christian, Hicks Andrew A, Hillman David R, Hingorani Aroon D, Hofman Albert, Hui Jennie, Hung Joe, Isomaa Bo, Johnson Paul R V, Jørgensen Torben, Jula Antti, Kaakinen Marika, Kaprio Jaakko, Kesaniemi Y Antero, Kivimaki Mika, Knight Beatrice, Koskinen Seppo, Kovacs Peter, Kyvik Kirsten Ohm, Lathrop G Mark, Lawlor Debbie A, Le Bacquer Olivier, Lecoeur Cécile, Li Yun, Lyssenko Valeriya, Mahley Robert, Mangino Massimo, Manning Alisa K, Martínez-Larrad María Teresa, McAteer Jarred B, McCulloch Laura J, McPherson Ruth, Meisinger Christa, Melzer David, Meyre David, Mitchell Braxton D, Morken Mario A, Mukherjee Sutapa, Naitza Silvia, Narisu Narisu, Neville Matthew J, Oostra Ben A, Orrù Marco, Pakyz Ruth, Palmer Colin N A, Paolisso Giuseppe, Pattaro Cristian, Pearson Daniel, Peden John F, Pedersen Nancy L, Perola Markus, Pfeiffer Andreas F H, Pichler Irene, Polasek Ozren, Posthuma Danielle, Potter Simon C, Pouta Anneli, Province Michael A, Psaty Bruce M, Rathmann Wolfgang, Rayner Nigel W, Rice Kenneth, Ripatti Samuli, Rivadeneira Fernando, Roden Michael, Rolandsson Olov, Sandbaek Annelli, Sandhu Manjinder, Sanna Serena, Sayer Avan Aihie, Scheet Paul, Scott Laura J, Seedorf Udo, Sharp Stephen J, Shields Beverley, Sigurðsson Gunnar, Sijbrands Eric J G, Silveira Angela, Simpson Laila, Singleton Andrew, Smith Nicholas L, Sovio Ulla, Swift Amy, Syddall Holly, Syvänen Ann-Christine, Tanaka Toshiko, Thorand Barbara, Tichet Jean, Tönjes Anke, Tuomi Tiinamaija, Uitterlinden André G, van Dijk Ko Willems, van Hoek Mandy, Varma Dhiraj, Visvikis-Siest Sophie, Vitart Veronique, Vogelzangs Nicole, Waeber Gérard, Wagner Peter J, Walley Andrew, Walters G Bragi, Ward Kim L, Watkins Hugh, Weedon Michael N, Wild Sarah H, Willemsen Gonneke, Witteman Jaqueline C M, Yarnell John W G, Zeggini Eleftheria, Zelenika Diana, Zethelius Björn, Zhai Guangju, Zhao Jing Hua, Zillikens M Carola, Borecki Ingrid B, Loos Ruth J F, Meneton Pierre, Magnusson Patrik K E, Nathan David M, Williams Gordon H, Hattersley Andrew T, Silander Kaisa, Salomaa Veikko, Smith George Davey, Bornstein Stefan R, Schwarz Peter, Spranger Joachim, Karpe Fredrik, Shuldiner Alan R, Cooper Cyrus, Dedoussis George V, Serrano-Ríos Manuel, Morris Andrew D, Lind Lars, Palmer Lyle J, Hu Frank B, Franks Paul W, Ebrahim Shah, Marmot Michael, Kao W H Linda, Pankow James S, Sampson Michael J, Kuusisto Johanna, Laakso Markku, Hansen Torben, Pedersen Oluf, Pramstaller Peter Paul, Wichmann H Erich, Illig Thomas, Rudan Igor, Wright Alan F, Stumvoll Michael, Campbell Harry, Wilson James F, Bergman Richard N, Buchanan Thomas A, Collins Francis S, Mohlke Karen L, Tuomilehto Jaakko, Valle Timo T, Altshuler David, Rotter Jerome I, Siscovick David S, Penninx Brenda W J H, Boomsma Dorret I, Deloukas Panos, Spector Timothy D, Frayling Timothy M, Ferrucci Luigi, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari, van Duijn Cornelia M, Aulchenko Yurii S, Cao Antonio, Scuteri Angelo, Schlessinger David, Uda Manuela, Ruokonen Aimo, Jarvelin Marjo-Riitta, Waterworth Dawn M, Vollenweider Peter, Peltonen Leena, Mooser Vincent, Abecasis Goncalo R, Wareham Nicholas J, Sladek Robert, Froguel Philippe, Watanabe Richard M, Meigs James B, Groop Leif, Boehnke Michael, McCarthy Mark I, Florez Jose C, Barroso Inês, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, 10.1038/ng.520
  50. Rosengren A. H., Jokubka R., Tojjar D., Granhall C., Hansson O., Li D.-Q., Nagaraj V., Reinbothe T. M., Tuncel J., Eliasson L., Groop L., Rorsman P., Salehi A., Lyssenko V., Luthman H., Renstrom E., Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes, 10.1126/science.1176827