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Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity

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Vanbel, PF. Gilliard, JA. Tilquin, Bernard [UCL]

Optimization procedures require adequate response criteria to assess the quality of each chromatogram obtained during the process. The objective of this paper is to evaluate the possibility of using different resolution functions, in the chromatographic separation of a drug and its impurities (particularly the impurity just eluted after the drug). This study shows the limits of some resolution expressions. The interest of the simple DELTAt criterion, the difference between retention times, is presented in this paper.

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Access type Accès restreint
Publication date 1993
Language Anglais
Conference "19TH INTERNATIONAL SYMP ON CHROMATOGRAPHY", AIX EN PROVENCE(France) (Sep 13-18, 1992)
Journal information "Chromatographia" - Vol. 36, p. 120-124 (1993)
Peer reviewed yes
issn 0009-5893
e-issn 1612-1112
Publisher Friedr Vieweg Sohn Verlag Gmbh (Wiesbaden 1)
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords Column Liquid Chromatography ; Method Development ; Chemometrics ; Response Criteria ; Analysis Of Drug Purity
Links
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  2. P. J. Schoenmakers, J. K. Strasters, A. Bartha, J. Chromatogr.458, 355 (1988).
  3. J. L. Glajch, J. J. Kirkland, K. M. Squire, J. M. Minor, J. Chromatogr.199, 57 (1980).
  4. J. L. Glajch, J. J. Kirkland, J. M. Minor, J. Liq. Chromatogr.10, 1727 (1987).
  5. P. J. Schoenmakers, H. A. H. Billiet, L. de Galan, J. Chromatogr.205, 13 (1981).
  6. R. D. Snee, Chemtech.9, 702 (1979).
Bibliographic reference Vanbel, PF. ; Gilliard, JA. ; Tilquin, Bernard. Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity.19TH INTERNATIONAL SYMP ON CHROMATOGRAPHY (AIX EN PROVENCE(France), Sep 13-18, 1992). In: Chromatographia, Vol. 36, p. 120-124 (1993)
Permanent URL http://hdl.handle.net/2078.1/63486