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Novel analogues of the anti HIV-1 agent TSAO-T modified at the 3'-spiro moiety.

  1. Balzarini J., Drugs of the Future, 18, 1043 (1993)
  2. Camarasa Maria, Péarez-Péarez Maria, Velázquez Sonsoles, San-Féalix Ana, Alvarez Rosa, Ingate Simon, Jimeno Maria Luisa, Karlsson Anna, De Clercq Erik, Balzarini Jan, TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication, 10.1080/15257779508012432
  3. Balzarini J., J. Biol. Chem., 267, 11831 (1992)
  4. Perez-Perez Maria Jesus, San-Felix Ana, Balzarini Jan, De Clercq Erik, Camarasa Maria Jose, TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine and pyrimidine-modified nucleosides, 10.1021/jm00094a009
  5. Ingate Simon, Pérez-Pérez María-Jesús, De Clercq Erik, Balzarini Jan, Camarasa María-José, Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2′- and 5′-positions of the sugar moiety, 10.1016/0166-3542(95)00012-b
  6. Balzarini J., Karlsson A., Vandamme A. M., Perez-Perez M. J., Zhang H., Vrang L., Oberg B., Backbro K., Unge T., San-Felix A., Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors., 10.1073/pnas.90.15.6952
  7. Balzarini J., Kleim J.P., Riess G., Camarasa M.J., Declercq E., Karlsson A., Sensitivity of (138 Glu → Lys) Mutated Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) to HIV-1-Specific RT Inhibitors, 10.1006/bbrc.1994.1846
  8. Perez-Perez Maria Jesus, San-Felix Ana, Balzarini Jan, De Clercq Erik, Camarasa Maria Jose, TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine and pyrimidine-modified nucleosides, 10.1021/jm00094a009
  9. Webb G. A., Annual reports on NMR spectroscopy, 25 (1993)
  10. Hayakawa H., Chem. Pharm. Bull., 35, 2605 (1987)
Bibliographic reference Alvarez, R ; Jimeno, ML ; De Clercq, Etienne ; Balzarini, Jan ; Camarasa, MJ. Novel analogues of the anti HIV-1 agent TSAO-T modified at the 3'-spiro moiety..XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides (LA JOLLA(Ca), Sep 15-19, 1996). In: Nucleosides and Nucleotides, Vol. 16, no. 7-9, p. 1033-1036 (1997)
Permanent URL http://hdl.handle.net/2078.1/62649