User menu

Therapeutic potential of HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues as broad-spectrum antiviral agents

Bibliographic reference Naesens, L ; De Clercq, Etienne. Therapeutic potential of HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues as broad-spectrum antiviral agents.XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides (LA JOLLA(Ca), Sep 15-19, 1996). In: Nucleosides and Nucleotides, Vol. 16, no. 7-9, p. 983-992 (1997)
Permanent URL
  1. Clercq Erik De, Sakuma Takashi, Baba Masanori, Pauwels Rudi, Balzarini Jan, Rosenberg Ivan, Holý Antonin, Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines, 10.1016/s0166-3542(87)80004-9
  2. Palú G., Stefanelli S., Rassu M., Parolin C., Balzarini J., De Clercq E., Cellular uptake of phosphonylmethoxyalkylpurine derivatives, 10.1016/0166-3542(91)90063-w
  3. Connelly Michele C., Robbins Brian L., Fridland Arnold, Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine (HPMPC) in vero cells, 10.1016/0006-2952(93)90670-r
  4. Cihlar T., Antimicrob. Agents Chemother., 39, 117 (1995)
  5. Cihlar T., Mol. Pharmacol. (1996)
  6. Merta Aleš, Votruba Ivan, Jindřich Jindřich, Holý Antonín, Cihlář Tomás̆, Rosenberg Ivan, Otmar Miroslav, Herve Tchaou Y., Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells, 10.1016/0006-2952(92)90110-5
  7. Robbins B. L., Antimicrob. Agents Chemother., 39, 2304 (1995)
  8. Balzarini J., J. Biol. Chem., 266, 8686 (1991)
  9. Xiong Xiaofeng, Smith Jeffrey L., Kim Choung, Huang Eng-shang, Chen Ming S., Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase, 10.1016/0006-2952(96)00100-1
  10. Cherrington J. M., Antiviral Chem. Chemother., 6, 217 (1995)
  11. Xiong X., Antimicrob. Agents Chemother. (1996)
  12. Cherrington Julie M., Allen Simon J., McKee Blaine H., Chen Ming S., Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylemthoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases β and γ, 10.1016/0006-2952(94)90600-9
  13. Kramata P., Mol. Pharmacol., 49, 1005 (1996)
  14. De Clercq E., Therapeutic potential of HPMPC as an antiviral drug, 10.1002/rmv.1980030205
  15. Naesens L., Balzarini J., De Clercq E., Therapeutic potential of PMEA as an antiviral drug, 10.1002/rmv.1980040302
  16. Tsai C.-C., Follis K. E., Sabo A., Beck T. W., Grant R. F., Bischofberger N., Benveniste R. E., Black R., Prevention of SIV Infection in Macaques by (R)-9-(2-Phosphonylmethoxypropyl)adenine, 10.1126/science.270.5239.1197
  17. Tsai Che-Chung, Follis Kathryn E., Grant Richard, Sabo Alexander, Nolte Randolph, Bartz Curtis, Bischofberger Norbert, Benveniste Raoul, Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques, 10.1111/j.1600-0684.1994.tb00119.x
  18. Van Rompay K. K. A., Antimicrob. Agents Chemother. (1996)
  19. Lalezari J. P., Lawrence Drew W., Glutzer E., Miner D., Safrin S., F. Owen W., Davidson J. M., Fisher P. E., Jaffe H. S., Treatment With Intravenous (S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)Propyl]-Cytosine Of Acyclovir-Resistant Mucocutaneous Infection With Herpes Simplexvirus In A Patient With Aids, 10.1093/infdis/170.3.570
  20. Lalezari J. P., Ann. Intern. Med. (1996)
  21. Kirsch Leonard S., Arevalo J. Fernando, de la Paz Eugenio Chavez, Munguia David, de Clerq Erik, Freeman William R., Intravitreal Cidofovir (HPMPC) Treatment of Cytomegalovirus Retinitis in Patients with Acquired Immune Deficiency Syndrome, 10.1016/s0161-6420(95)30985-2
  22. Snoeck R., Andrei G., Gerard M., Silverman A., Hedderman A., Balzarini J., Sadzot-Delvaux C., Tricot G., Clumeck N., De Clercq E., Successful Treatment of Progressive Mucocutaneous Infection Due to Acyclovirand Foscarnet-Resistant Herpes Simplex Virus with (S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine (HPMPC), 10.1093/clinids/18.4.570
  23. Van Cutsem E., Janssens J., Rutgeerts P., Vantrappen G., Snoeck R., Van Ranst M., Fiten P., Opdenakker G., De Clercq E., Geboes K., Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, 10.1002/jmv.1890450221
  24. Snoeck R., Antiviral Res., 30, A25 (1996)
  25. Snoeck R., Van Ranst M., Andrei G., De Clercq E., De Wit S., Poncin M., Clumeck N., Treatment of Anogenital Papillomavirus Infections with an Acyclic Nucleoside Phosphonate Analogue, 10.1056/nejm199510053331418
  26. Cundy K. C., Barditch-Crovo P., Walker R. E., Collier A. C., Ebeling D., Toole J., Jaffe H. S., Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients, 10.1128/aac.39.11.2401
  27. Naesens L., Antimicrob. Agents Chemother., 40, 22 (1996)
  28. Barditch-Crovo P. A., Antiviral Res., 26, A229 (1995)
  29. Gilson, R. J., Chopra, K., Murray-Lyon, I., Newell, A., Nelson, M., Tedder, R. S., Toole, J., Jaffe, H. S., Hellmann, N. and Weller, I. V. D. 1996. Presented at 36th ICAAC Meeting. September15–181996, New Orleans, Louisiana, U.S.A. Abstract book, Abstract No. LB1
  30. Fol Andrea, Sogocio Kristina M., Anderson Barry, Kavlick Mark, Saville M.Wayne, Wainberg Mark A., Gu Zhengxian, Cherrington Julie M., Mitsuya Hiroaki, Yarchoan Robert, In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 10.1016/0166-3542(95)00985-x
  31. Cherrington J. M., Antimicrob. Agents Chemother., 40, 2212 (1996)