The production and quality control analysis of short-lived (t(1/2)=2.03 min) oxygen-15 labelled gases ([O-15]O-2, [O-15]CO, and [O-15]CO2) from a Cyclone 3D accelerator for positron emission tomography (PET) in human subjects has been established and evaluated on a routine basis use at the MRC Cyclotron Unit and are here described. Contaminant levels have been identified and measured by radio-gas chromatography. The maximum levels allowed, measured as a percentage of total delivered activity (v/v), are 3.7% for total nitrogen oxides and 1% for [O-15]CO in [O-15]CO2 and [O-15]CO2 in [O-15]CO. By adjunction of a cryogenic or molecular sieve trap, radiopharmaceutical gases are routinely produced well within these specifications. (C) 1999 Elsevier Science Ltd. All rights reserved.
Mackay, DB ; Steel, CJ ; Poole, K ; McKnight, S ; Schmitz, F ; et. al. Quality assurance for PET gas production using the cyclone 3D oxygen-15 generator.7th International Workshop on Targetry and Target Chemistry (HEIDELBERG(Germany), Jun 08-11, 1997). In: Applied Radiation and Isotopes, Vol. 51, no. 4, p. 403-409 (1999)
