User menu

Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects

Bibliographic reference Quertemont, E. ; Eriksson, CJP ; Zimatkin, SM ; Pronko, PS ; Diana, M ; et. al. Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects.12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (Mannheim(Germany), Sep 29-oct 02, 2004). In: Alcoholism: Clinical and Experimental Research, Vol. 29, no. 8, p. 1514-1521 (2005)
Permanent URL http://hdl.handle.net/2078.1/60890
  1. Aragon C.M.G., Abitbol Muriel, Amit Z., Acetaldehyde may mediate reinforcement and aversion produced by ethanol, 10.1016/0028-3908(86)90062-6
  2. C.M.G. A, The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: Evidence for brain catalase involvement in the mechanism of action, 10.1016/0028-3908(92)90150-n
  3. Aragon Carlos M.G., Rogan Franc, Amit Zalman, Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system, 10.1016/0006-2952(92)90042-h
  4. Baraona Enrique, Yokoyama Akira, Ishii Hiromasa, Hernández-Muñoz Rolando, Takagi Toshikazu, Tsuchiya Masaharu, Lieber Charles S., Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects, 10.1016/0024-3205(91)90295-m
  5. Blanchard Betty A., Glick Stanley D., Sex Differences in Mesolimbic Dopamine Responses to Ethanol and Relationship to Ethanol Intake in Rats, Recent Developments in Alcoholism (2002) ISBN:9780306449215 p.231-241, 10.1007/0-306-47138-8_15
  6. Bozarth Michael A., Wise Roy A., Electrolytic microinfusion transducer system: an alternative method of intracranial drug application, 10.1016/0165-0270(80)90016-3
  7. Brodie Mark S., Shefner Sarah A., Dunwiddie Thomas V., Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro, 10.1016/0006-8993(90)91118-z
  8. Brown Z. W., Amit Z., Rockman G. E., Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats, 10.1007/bf00427509
  9. Chick J, Br J Psychiatry, 161, 84 (1992)
  10. Correa M., Arizzi M.N., Betz A., Mingote S., Salamone J.D., Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate, 10.1016/j.brainresbull.2003.09.013
  11. Deitrich RA, J Stud Alcohol, 65, 557 (2004)
  12. Diana M., Garcia-Munoz M., Richards J., Freed C.R., Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats, 10.1007/bf00247365
  13. Diana M, Proc Natl Acad Sci U S A, 90, 7966 (1993)
  14. Eriksson C. J. Peter, The Role of Acetaldehyde in the Actions of Alcohol (Update 2000), 10.1111/j.1530-0277.2001.tb02369.x
  15. Fuller R. K., Disulfiram treatment of alcoholism. A Veterans Administration cooperative study, 10.1001/jama.256.11.1449
  16. Gatto G.J., McBride W.J., Murphy J.M., Lumeng L., Li T.-K., Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats, 10.1016/0741-8329(94)90083-3
  17. Gessa Gian Luigi, Muntoni Francesco, Collu Maria, Vargiu Lidia, Mereu Giampaolo, Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area, 10.1016/0006-8993(85)90381-6
  18. Gill K., Menez J. F., Lucas D., Deitrich R. A., Enzymatic Production of Acetaldehyde from Ethanol in Rat Brain Tissue, 10.1111/j.1530-0277.1992.tb01892.x
  19. Goeders Nick E., Smith James E., Intracranial self-administration methodologies, 10.1016/s0149-7634(87)80017-9
  20. Grace AA, J Neurosci, 4, 2877 (1984)
  21. Hamby-Mason R, Alcohol Clin Exp Res, 21, 1063 (1997)
  22. Hansson T., Tindberg N., Ingelman-Sundberg M., Ko¨hler C., Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system, 10.1016/0306-4522(90)90154-v
  23. Heap Laura, Ward Roberta J., Abiaka Clifford, Dexter David, Lawlor Monica, Pratt Oliver, Thomson Allan, Shaw Ken, Peters T.J., The influence of brain acetaldehyde on oxidative status, dopamine metabolism and visual discrimination task, 10.1016/0006-2952(94)00539-x
  24. Hoebel Bartley G., Monaco Anthony P., Hernandez Luis, Aulisi Edward F., Stanley B. Glenn, Lenard Laszlo, Self-injection of amphetamine directly into the brain, 10.1007/bf00429012
  25. Hunt Walter A., Role of acetaldehyde in the actions of ethanol on the brain — A review, 10.1016/0741-8329(95)02026-8
  26. Imperato A, J Pharmacol Exp Ther, 239, 219 (1986)
  27. Litten Raye Z., Fertig Joanne, International Update: New Findings on Promising Medications, 10.1111/j.1530-0277.1996.tb01779.x
  28. Martinez Susana E., Vaglenova Julia, Sabria Josefa, Martinez M. Carmen, Farres Jaume, Pares Xavier, Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. . Consequences for brain ethanol and retinoid metabolism, 10.1046/j.0014-2956.2001.02416.x
  29. Pianezza Michael L., Sellers Edward M., Tyndale Rachel F., 10.1038/31623
  30. Pulvirenti L, Neurosci Rev, 12, 41 (2001)
  31. Quertemont E, Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism, 10.1038/sj.mp.4001497
  32. Quertemont Etienne, De Witte Philippe, Conditioned stimulus preference after acetaldehyde but not ethanol injections, 10.1016/s0091-3057(00)00486-x
  33. Quertemont Etienne, Tambour Sophie, Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol, 10.1016/j.tips.2004.01.001
  34. Quertemont Etienne, Tambour Sophie, Bernaerts Pascale, Zimatkin Sergey M., Tirelli Ezio, Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects, 10.1007/s00213-004-1911-x
  35. Rodd ZA, J Pharmacol Exp Ther (2005)
  36. Rodd Zachary A, Bell Richard L, Zhang Ying, Murphy James M, Goldstein Avram, Zaffaroni Alejandro, Li Ting-Kai, McBride William J, Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin, 10.1038/sj.npp.1300561
  37. Rodd Z. A., Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons, 10.1523/jneurosci.1319-03.2004
  38. Rodd-Henricks Z. A., McKinzie David L., Crile Robert S., Murphy James M., McBride William J., Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats, 10.1007/s002139900347
  39. Rodd-Henricks Z. A., Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats, 10.1124/jpet.102.038950
  40. Rodd-Henricks ZA, Psychopharmacology, 165, 252 (2003)
  41. Rodd-Henricks Zachary A., Melendez Roberto I., Zaffaroni Alejandro, Goldstein Avram, McBride William J., Li Ting-Kai, The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats, 10.1016/s0091-3057(01)00733-x
  42. Rossetti Zvani L., Hmaidan Yousef, Gessa Gian Luigi, Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats, 10.1016/0014-2999(92)90706-a
  43. Smith B.R, Amit Z, Splawinsky J, Conditioned place preference induced by intraventricular infusions of acetaldehyde, 10.1016/0741-8329(84)90097-1
  44. SMITH BRIAN R., ARAGON CARLOS M. G., AMIT ZALMAN, Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol, 10.1080/13556219772570
  45. Upadhya Sudarshan C., Tirumalai Padmashree S., Boyd Michael R., Mori Toshiyuki, Ravindranath Vijayalakshmi, Cytochrome P4502E (CYP2E) in Brain: Constitutive Expression, Induction by Ethanol and Localization by Fluorescence in Situ Hybridization, 10.1006/abbi.1999.1477
  46. Waller M.B., McBride W.J., Lumeng L., Li T.-K., Effects of intravenous ethanol and of 4-methylpyrazole on alcohol drinking in alcohol-preferring rats, 10.1016/0091-3057(82)90359-8
  47. WARD R.J, COLANTUONI C, DAHCHOUR A, QUERTEMONT E, DE WITTE P, Acetaldehyde-induced Changes in the Monoamine and Amino Acid Extracellular Microdialysate Content of the Nucleus Accumbens, 10.1016/s0028-3908(97)00007-5
  48. Ward R. J., Coutelle Ch., Women and alcohol susceptibility: Could differences in alcohol metabolism predispose women to alcohol-related diseases?, 10.1007/s00737-003-0015-7
  49. Ward RJ, Alcohol Alcohol, 36, 39 (2001)
  50. Weiss F, J Neurosci, 16, 3474 (1996)
  51. Zimatkin SM, J Neurochem, 56, 1 (1991)
  52. ZIMATKIN SERGEY M., DEITRICH RICHARD A., Ethanol metabolism in the brain, 10.1080/13556219772444
  53. Zimatkin SM, Alcohol Clin Exp Res, 22, 1623 (1998)
  54. Zimatkin Sergey M., Liopo Anton V., Slychenkov V. S., Deitrich Richard A., Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals, 10.1111/j.1530-0277.2001.tb02305.x
  55. Zimatkin Sergey M., Liopo Anton V., Satanovskaya Valentina I., Bardina Lubov R., Deitrich Richard A., Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. II: Studies in Selectively Bred Rats and Mice, 10.1111/j.1530-0277.2001.tb02306.x