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Formation of perthiyl free radicals in irradiated glutathione

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Terryn, Hélène [UCL] Tilquin, Bernard [UCL] Houee-Levin, C

The irradiation of reduced (GSH) or oxidized (GSSG) glutathione in the solid state was performed using gamma-rays from Co-60 or high-energy electrons from an accelerator. In GSSG, perthiyl radicals (GSS') were created in addition to carbon-centred radicals as seen by electron paramagnetic resonance spectroscopy. The quantity was independent of the dose rate (electrons or gamma-rays) and of the presence of oxygen. In GSH, perthiyl radicals were also created, although in a smaller quantity. Among end-products in irradiated GSSG, we find GSH. Thus, sulphur functions are reduced by irradiation in the solid state.

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Publication date 2005
Language Anglais
Conference "7th Biennial Trombay Symposium on Radiation and Photochemistry (TSRP 2004)", Bombay(India) (Jan 08-12, 2004)
Journal information "Research on Chemical Intermediates : an international journal" - Vol. 31, no. 7-8, p. 727-736 (2005)
Peer reviewed yes
issn 0922-6168
e-issn 1568-5675
Publisher Vsp Bv (Zeist)
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords Glutathione ; Electron Paramagnetic Resonance ; Radiolysis ; Sulphur Free Radicals ; Perthiyl Radicals
Links
Bibliographic reference Terryn, Hélène ; Tilquin, Bernard ; Houee-Levin, C. Formation of perthiyl free radicals in irradiated glutathione.7th Biennial Trombay Symposium on Radiation and Photochemistry (TSRP 2004) (Bombay(India), Jan 08-12, 2004). In: Research on Chemical Intermediates : an international journal, Vol. 31, no. 7-8, p. 727-736 (2005)
Permanent URL http://hdl.handle.net/2078.1/60868