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Plasma-levels of Doxorubicin After Iv Bolus Injection and Infusion of the Doxorubicin-dna Complex in Rabbits and Man - Comparison With Free Doxorubicin

Bibliographic reference Baurain, R. ; Deprezdecampeneere, D. ; Zenebergh, A. ; Trouet, André. Plasma-levels of Doxorubicin After Iv Bolus Injection and Infusion of the Doxorubicin-dna Complex in Rabbits and Man - Comparison With Free Doxorubicin. In: Cancer Chemotherapy and Pharmacology, Vol. 9, no. 2, p. 93-96 (1982)
Permanent URL http://hdl.handle.net/2078.1/57764
  1. Bachur NR, Hildebrand RC, Jaenke RS (1974) Adriamycin and daunorubicin disposition in the rabbit. J Pharmacol Exp Ther 191:331?350
  2. Baurain R, Deprez-De Campeneere D, Trouet A (1979a) Determination of daunorubicin, doxorubicin and their fluorescent metabolites by high-pressure liquid chromatography: plasma levels in DBA2 mice. Cancer Chemother Pharmacol 2:11?14
  3. Baurain R, Deprez-De Campenecre D, Trouet A (1979b) Rapid determination of doxorubicin and its fluorescent metabolites by high-pressure liquid chromatography. Anal Biochem 94:112?116
  4. Blanchard JC, Schneider Y-J, Baurain R, Trouet A (1981) Accumulation, metabolism and subcellular localization of daunorubicin, doxorubicin and their DNA-complexes in rat heart ventricles. Eur J Cancer 17:297?305
  5. Commerford SL (1971) Iodination of nucleic acids in vitro. Biochemistry 10:1993?1999
  6. Deprez-De Campeneere D, Baurain R, Huybrechts M, Trouet A (1979) Comparative study in mice of the toxicity, pharmacology and therapeutic activity of daunorubicin-DNA and doxorubicin-DNA complexes. Cancer Chemother Pharmacol 2:25?30
  7. Lie SO, Lie KK, Glomstein A (1979) Clinical and pharmacological studies with adriamycin-DNA complex in children with malignant disease. Cancer Chemother Pharmacol 2:61?66
  8. Niazi S (1979) Multicompartment pharmacokinetic analysis and simulations using a programmable calculator. Int J Biomed Comput 10:245?255
  9. Orosz JM, Wetmur JG (1974) In vitro iodination of DNA. Maximizing iodination while minimizing degradation. Use of buoyant density shift for DNA-DNA hybrid isolation. Biochemistry 13:5467?5473
  10. Paul C, Lönnqvist B, Gahrton G, Peterson C (1981) Reducing the cardiotoxicity of anthracyclines by complex-binding to DNA: report of three cases. Cancer 48:1531?1534
  11. Schneider Y-J, Baurain R, Zenebergh A, Trouet A (1979) DNA binding parameters of daunorubicin and doxorubicin in the conditions used for studying the interactions of anthracyclines-DNA complexes with cells in vitro. Cancer Chemother Pharmacol 2:7?10
  12. Trouet A (1978) Increased selectivity of drugs by linking to carriers. Eur J Cancer 14:105?111
  13. Trouet A, Deprez-De Campeneere D (1979) Daunorubicin-DNA and doxorubicin-DNA: a review of experimental and clinical data. Cancer Chemother Pharmacol 2:77?79
  14. Trouet A, Sokal G (1979) Clinical trials with daunorubicin-DNA and adriamycin-DNA complexes: a review. Cancer Treat Rep 63:895?898
  15. Trouet A, Deprez-De Campeneere D, de Smedt-Malengreaux M, Atassi G (1974) Experimental leukemia chemotherapy with a ?lysosomotropic? adriamycin-DNA complex. Eur J Cancer 10:405?411
  16. Trouet A, Deprez-De Campeneere D, Baurain R, Huybrechts M, Zenebergh A (1979) Desoxyribonucleic acid as carrier for anti-tumoral drugs. In: Gregoriadis G (ed) Carriers in biology and medicine. Academic Press, London, pp 87?105
  17. Trouet A, Masquelier M, Baurain R, Deprez-De Campeneere D (1982) A covalent linkage between daunorubicin and proteins that is both stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo study. Proc Natl Acad Sci USA 79:626?630
  18. Zenebergh A, Schneider Y-J, Trouet A (1980) Comparative studies of the accumulation of doxorubicin and doxorubicin-DNA in various cell lines. Biochem Pharmacol 29:1035?1040