User menu

Morphological Alterations in Distal and Collecting Tubules of the Rat Renal-cortex After Aminoglycoside Administration At Low-doses

Bibliographic reference Toubeau, G. ; Maldague, Pierre ; Laurent, G. ; Vaamonde, CA. ; Tulkens, Paul M. ; et. al. Morphological Alterations in Distal and Collecting Tubules of the Rat Renal-cortex After Aminoglycoside Administration At Low-doses. In: Virchows Archiv. Section B: Cell Pathology, Vol. 51, no. 6, p. 475-485 (1986)
Permanent URL http://hdl.handle.net/2078.1/54355
  1. APPEL GERALD B., Gentamicin in 1978, 10.7326/0003-4819-89-4-528
  2. Bennett WM, Luft F, Porter GA (1980) Pathogenesis of renal failure due to aminoglycosides and contrast media used in roentgenography. Am J Med 69:767–774
  3. Brasseur R, Laurent G, Ruysschaert JM, Tulkens PM (1984) Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochem Pharmacol 33:629–637
  4. Cuppage FE, Setter K, Sullivan LP, Reitzes EJ, Melnykovych RO (1977) Gentamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats. Virchows Arch [Cell Pathol] 24:121–138
  5. De Broe ME, Paulus GJ, Verpooten GA, Roels F, Buyssens N, Wedeen R, Van Hoof F, Tulkens PM (1984) Early effects of gentamicin, tobramycin and amikacin on the human kidney. Kidney Int 25:643–652
  6. Fabre J, Rudhardt M, Blanchard P, Regamey C (1976) Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int 10:444–449
  7. Gilbert D. N., Plamp C., Starr P., Bennett W. M., Houghton D. C., Porter G., Comparative Nephrotoxicity of Gentamicin and Tobramycin in Rats, 10.1128/aac.13.1.34
  8. Giurgea-Marion L, Toubeau G, Laurent G, Heuson-Stiennon JA, Tulkens PM (1986) Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low dose. Toxicol Appl Pharmacol (in press)
  9. Houghton DC, Hartnett MV, Campbell-Boswell MV, Porter GA, Bennett WM (1976) A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am J Pathol 82:589–612
  10. Houghton DC, Plamp CE, De Fehr JM, Bennett WM, Porter GA, Gilbert D (1978) Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. Am J Pathol 93:137–152
  11. Josepovitz C, Levine R, Lane B, Kaloyanides GJ (1985) Contrasting effects of gentamicin and mercuric chloride on urinary excretion of enzymes and phospholipids in the rat. Lab Invest 52:375–386
  12. Just M, Erdmann G, Habermann E (1977) The renal handling of polybasic drugs. I. Gentamicin and aprotinin in intact animals. Naunyn-Schmiedeberg’s Arch Pharmacol 300:57–66
  13. Kosek JC, Mazze RI, Cousins MJ (1974) Nephrotoxicity of gentamicin. Lab Invest 30:48–57
  14. Laurent G, Carlier MB, Rollmann B, Van Hoof F, Tulkens PM (1982) Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with Gentamicin and amikacin. Biochem Pharmacol 31:3861–3870
  15. Lietman PS (1985) Aminoglycosides and spectinomycin: aminocyclitols. In: Mandell GL, Douglas RG, Bennett JE (eds) Principles and practice of infections diseases. John Wiley and Sons, New York, pp 192–206
  16. Luft F. C., Kleit S. A., Renal Parenchymal Accumulation of Aminoglycoside Antibiotics in Rats, 10.1093/infdis/130.6.656
  17. Luft FC, Patel V, Yum MN, Patel B, Kleit SA (1975) Experimental aminoglycoside nephrotoxicity. J Lab Clin Med 86:213–220
  18. Maunsbach AB (1966a) The influence of different fixatives and fixation methods on the ultrastructure of rat kidney proximal tubule cells. I. Comparison of different perfusion fixation methods and of glutaraldehyde, formaldehyde and osmium tetroxide fixatives. J Ultrastruct Res 15:242–281
  19. Maunsbach Arvid B., The influence of different fixatives and fixation methods on the ultrastructure of rat kidney proximal tubule cells, 10.1016/s0022-5320(66)80110-7
  20. Safirstein R, Miller P, Kahn G (1983) Cortical and papillary defects in gentamicin nephrotoxicity. Kidney Int 24:526–533
  21. Sande ME, Mandell GL (1985) The aminoglycosides. In: Goodman, Gilman, Rall, Murad (eds) The pharmacological basis of therapeutics. Macmillan Publishing Company, New York, pp 1150–1169
  22. Sastrasinh M, Knauss TC, Weinberg JM, Humes DH (1982) Identification of the aminoglycoside binding site in rat renal brush border membranes. J Pharmacol Exp Ther 222:350–358
  23. Schentag J J, Plaut M E, Cerra F B, Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients., 10.1128/aac.19.5.859
  24. Silverblatt FJ, Kuehn C (1979) Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int 15:335–345
  25. Silverblatt FJ (1982) Autoradiographic studies of intracellular aminoglycoside disposition in the kidney. In: Whelton A, Neu HC (eds) The aminoglycosides: microbiology, clinical use, and toxicology. Marcel Dekker Inc., New York, pp 223–233
  26. Soberon L, Bowman RL, Pastoriza-Munoz E, Kaloyanides GJ (1979) Comparative nephrotoxicities of gentamicin, netilmicin and tobramycin in the rat. J Pharmacol Exp Ther 210:334–343
  27. Toubeau G, Laurent G, Heuson-Stiennon JA, Tulkens PM (1984) Aminoglycoside-induced alterations in distal and collecting tubules of rat kidney cortex [Abstr]. 2ème Colloque Annuel de la Société de Biologie Cellulaire de France, Paris
  28. Tulkens P, Laurent G, Carlier MB, Toubeau G, Heuson-Stiennon JA, Maldague P (1983) Comparative study of the alterations induced in rat kidney by gentamicin, dibekacin, netilmicin, tobramycin and amikacin at low doses. Proceedings of the 13th International Congress of Chemotherapy, Vienna, August 28th–September 2nd 1983, Spitzy KH, Karrer K (eds) pp 86/30–86/35
  29. Vaamonde CA (1984) Antibiotic-induced nephrotoxicity. In: Robinson RR (ed) Nephrology vol. 1. Proceedings of the IX International Congress of Nephrology, Los Angeles, Springer, New York, pp 844–868
  30. Watanabe M (1978) Drug-induced lysosomal changes and nephrotoxicity in rats. Acta Pathol Jpn 28:867–889
  31. Whelton Andrew, Therapeutic Initiatives for the Avoidance of Aminoglycoside Toxicity, 10.1002/j.1552-4604.1985.tb02805.x
  32. Williams PD, Trimble ME, Crespo L, Holohan PD, Freedman JC, Ross CR (1984) Inhibition of renal Na+, K+-adenosine triphosphatase by gentamicin. J Pharmacol Exp Ther 231:248–253
  33. Wilmotte E, Maldague P, Tulkens PM, Baumgartner R, Schmook F, Walzl H, Obenaus H (1983) S 86451, a new derivative of gentamicin with reduced nephrotoxicity: biochemical, morphological and functional studies. Drugs Exptl Clin Res 9:467–477