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Search for anti-laminin antibodies in the serum of workers exposed to cadmium, mercury vapour or lead

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Bernard, Alfred [UCL] Roels, Harry [UCL] Foidart, J.M. Lauwerys, Robert [UCL]

Anti-laminin antibodies were sought for in the serum of workers exposed to mercury vapour (Hg, n = 58), lead (Pb, n = 38) or cadmium (Cd, n = 47). Thirty-one workers removed from Cd exposure for an average of eight years were also examined. Compared with control workers matched for age and socio-economic status, the prevalence of circulating anti-laminin antibodies was not increased in workers exposed to Hg (mean duration of exposure: 7.9 years and mean urinary excretion of Hg: 72 micrograms/g creatinine) nor in those exposed to Pb (mean duration of exposure: 10.6 years and mean Pb levels in blood: 535 micrograms/l). In contrast, anti-laminin antibodies were significantly more prevalent in Cd-exposed workers whose urinary Cd exceeded 20 micrograms/g creatinine. This observation was made in both currently exposed workers and in workers removed from Cd exposure (mean duration of exposure: 9.4 and 24.6 years and mean urinary Cd: 7.8 and 13.4 micrograms/g creatinine respectively). These autoantibodies were found in Cd workers with normal renal function as well as in those with increased proteinuria.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1987
Language Anglais
Journal information "International Archives of Occupational and Environmental Health" - Vol. 59, no. 3, p. 303-309 (1987)
Peer reviewed yes
Publisher Springer (Heidelberg)
issn 0340-0131
e-issn 1432-1246
Publication status Publié
Affiliations UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Centre de toxicologie clinique
UCL - (SLuc) Service d'anatomie pathologique
Keywords Mercury ; Lead ; Cadmium ; Anti-laminin antibodies
Links
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  2. Bernard A, Lauwerys R (1983) Continuous flow system for automation of latex immunoassay by particle counting. Clin Chem 29:1007?1011
  3. Bernard A, Lauwerys R, Gengoux P, Mahieu P, Foidart JM, Druet P, Weening JJ (1984) Anti-laminin and anti-type IV procollagen antibodies in Sprague-Dawley and Brown-Norway rats chronically exposed to cadmium. Toxicology 31:307?313
  4. Bernard A, Mahieu P, Foidart JM, Lauwerys R (1986a) Anti-basement membrane antibodies in the serum of healthy subjects. N Engl J Med 314:1456?1457
  5. Bernard A, Foidart JM, Mahieu P, Viau C, Lauwerys R (1986b) Detection of anti-laminin antibodies in sera by latex agglutination test. Clin Chem 32:1468?1472
  6. Druet P, Bernard A, Hirsch F, Weening JJ, Gengoux P, Mahieu P, Birkeland S (1982) Immunologically mediated glomerulonephritis induced by heavy metals. Arch Toxicol 50:187?194
  7. Henry RJ (1965) Clinical chemistry. Principles and technics. Harper and Row, New York
  8. Lauwerys R, Bernard A, Roels H, Buchet JP, Gennart JP, Mahieu P, Foidart JM (1983) Anti-laminin antibodies in workers exposed to mercury vapour. Toxicol Lett 17:113?116
  9. Lauwerys R (1983) Industrial chemical exposure: guidelines for biological monitoring. Biomedical Publications, Davis, California
  10. Lawrence DA (1985) Immunotoxicity of heavy metals. In: Dean JH, Munson A, Luster M, Amos H (ed) Immunotoxicology and immunopharmacology. Raven Press, New York, pp 341?353
  11. Roels HA, Buchet JP, Lauwerys R, Bruaux P, Claeys-Thoreau F, Lafontaine A, Van Overschelde J, VerduynG (1978) Lead and cadmium absorption among children near a non-ferrous metal plant. A follow-up study of a test case. Environ Res 15:290?308
  12. Stonard MD, Chater BV, Duffield DP, Sullivan JJ, Lockwood M (1983) Circulating immune complexes in individuals occupationally exposed to mercury vapour. In: Brown SS, Savory J (ed) Chemical toxicology and clinical chemistry of metals. Proc 2nd Int Conf in Montreal. Academic Press, London, pp 135?138
  13. Wedeen RP, Mallick DK, Batuman V (1979) Detection and treatment of occupational lead nephropathy. Arch Int Med 139:53?57
Bibliographic reference Bernard, Alfred ; Roels, Harry ; Foidart, J.M. ; Lauwerys, Robert. Search for anti-laminin antibodies in the serum of workers exposed to cadmium, mercury vapour or lead. In: International Archives of Occupational and Environmental Health, Vol. 59, no. 3, p. 303-309 (1987)
Permanent URL http://hdl.handle.net/2078.1/53903