User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Synthesis and Biological Evaluation of P,P'-dideuteriophenytoin

  1. Meldrum, J. Med. Chem., 24, 644 (1981)
  2. Porter, J. Med. Chem., 51, 293 (1984)
  3. Antiepileptic Drugs: Mechanism of Action (1980)
  4. Casey D. L., Gwilt P. R., Digenis G. A., Perrier D. G., A convenient synthesis of deuterium labelled diphenylhydantoin, 10.1002/jlcr.2580130422
  5. Andresen Brian D., Biemann K., A synthesis of 5-phenyl-d5-phenyl-d5-hydantoin, 10.1002/jlcr.2580150154
  6. Coombe RG, Poulton DB, Preparation of 5,5-Bis(2-deuterophenyl)hydantoin, 10.1071/ch9780451
  7. Dumont, J. Pharm. Belg., 36, 21 (1981)
  8. Poupaert J. H. Claesen M. Adline J. Dumont P. A. J. Chem. research (S) 174 175 1979
  9. Kepler J. A., Preparation of tritium labeled diphenylhydantoin of high specific activity, 10.1002/jlcr.2590110417
  10. Poupaert Jacques H., Winand Martial, Dumont P., An efficient synthesis of 5-(phenyl-13C6)-5-phenylhydantoin, 10.1002/jlcr.2580181216
  11. Kepler J. A., Lytle J. W., Taylor G. F., Synthesis of 5,5-diphenylhydantion-2,4,5-13C3, 10.1002/jlcr.2590100420
  12. Emran Ali M., Boothe Thomas E., Finn Ronald D., Vora Manhar M., Kothari Paresh J., Use of 11C as a tracer for studying the synthesis of radiolabelled compounds—II: 2-[11C]-5,5-diphenylhydantoin from [11C]cyanide, 10.1016/0883-2889(86)90043-2
  13. Baty J. D., Robinson P. R., Single and multiple ion recording techniques for the analysis of diphenylhydantoin and its major metabolite in plasma, 10.1002/bms.1200040104
  14. Hoskins John A, The synthesis of deuterium labelled mono-hydroxy metabolites of phenytoin, 10.1002/jlcr.2580210709
  15. Poupaert, J. Pharm. Eelg., 37, 47 (1982)
  16. van Langenhove A., Costello C. E., Biller J. E., Biemann K., Browne T. R., A mass spectrometric method for the determination of stable isotope labeled phenytoin suitable for pulse dosing studies, 10.1002/bms.1200071126
  17. Claesen, Drug Metabol. Dispos., 10, 667 (1982)
  18. Moustafa, Drug Metabol. Dispos., 11, 574 (1983)
  19. Poupaert Jacques H., Cavalier Robert, Claesen Michel H., Dumont Pierre A., Absolute configuration of the major metabolite of 5,5-diphenylhydantoin,5-(4'-hydroxyphenyl)-5-phenylhydantoin, 10.1021/jm00246a024
  20. Poupaert, Workshop on Drug Metabolism, 118, 116 (1984)
  21. Shenoy Ananth K., Miyahara James T., Swinyard Ewart A., Kupferberg Harvey J., Comparative Anticonvulsant Activity and Neurotoxicity of Clobazam, Diazepam, Phenobarbital, and Valproate in Mice and Rats, 10.1111/j.1528-1157.1982.tb05426.x
  22. Poupaert Jacques H., Vandervorst Daniel, Guiot Pierre, Moustafa Mohamed M. M., Dumont Pierre, Structure-activity relationships of phenytoin-like anticonvulsant drugs, 10.1021/jm00367a015
  23. Millard, Quantitative Mass Spectrometry (1979)
  24. Beilstein 7 423
  25. Handbook of Chemistry and Physics (1971-1972)
Bibliographic reference Poupaert, Jacques ; Guiot, P. ; Dumont, Pierre. Synthesis and Biological Evaluation of P,P'-dideuteriophenytoin. In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 25, no. 1, p. 43-51 (1988)
Permanent URL http://hdl.handle.net/2078.1/53331