User menu

The Cyclic Dimer of 5-fluoro-2'-deoxyuridylic Acid - a Potent Anticancer Agent

Bibliographic reference Hamoir, G. ; Sonveaux, Etienne ; Iigo, M. ; De Clercq, Etienne. The Cyclic Dimer of 5-fluoro-2'-deoxyuridylic Acid - a Potent Anticancer Agent. In: Nucleosides and Nucleotides, Vol. 8, no. 2, p. 285-295 (1989)
Permanent URL
  1. Houghton Janet A., Weiss Karen D., Williams Larry G., Torrance Pamela M., Houghton Peter J., Relationship between 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas, 10.1016/0006-2952(86)90281-9
  2. Balzarini Jan, De Clercq Erik, Mertes Mathias P., Shugar David, Torrence Paul F., 5-substituted 2′-deoxyuridines: Correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase, 10.1016/0006-2952(82)90594-9
  3. Balzarini J., De Clercq E., Torrenc P.F., Mertes M.P., Park J.S., Schmidt C.L., Shugar D., Barra P.J., Jones A.S., Verhelst G., Walker R.T., Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines, 10.1016/0006-2952(82)90347-1
  4. De Clercq E., Mol. Pharmacol., 19, 321 (1981)
  5. Desgranges C., Cancer Res., 46, 1094 (1986)
  6. Iigo M., Cancer Treatment Reports, 63, 1895 (1979)
  7. Iigo M., J. Natl. Cancer Inst., 66, 345 (1981)
  8. Byfield J. E., Cancer Treatment Reports, 69, 645 (1985)
  9. Armstrong R. D., Cancer Res., 41, 4891 (1981)
  10. de Bruijn E. A., Cancer Res., 45, 5931 (1985)
  11. Fukushima S., Cancer Res., 47, 1930 (1987)
  12. Farquhar David, Kuttesch Nancy J., Wilkerson Michael G., Winkler Tammo, Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate, 10.1021/jm00362a013
  13. Hunston Roger N., Jones A. Stanley, McGuigan Christopher, Walker Richard T., Balzarini Jan, De Clercq Erik, Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine, 10.1021/jm00370a005
  14. Rode Wojciech, Kulikowski Tadeusz, Kedzierska Barbara, Shugar David, Studies on the interaction with thymidylate synthase of analogues of 2′-deoxyuridine-5′-phosphate and 5-fluoro-2′-deoxyuridine-5′-phosphate with modified phosphate groups, 10.1016/0006-2952(87)90690-3
  15. Tener G. M., Khorana H. G., Markham R., Pol E. H., Studies on Polynucleotides. II.1The Synthesis and Characterization of Linear and Cyclic Thymidine Oligonucleotides2, 10.1021/ja01556a017
  16. Catlin Joseph C., Cramer Friedrich, Deoxy oligonucleotide synthesis via the triester method, 10.1021/jo00942a011
  17. François P., Hamoir G., Sonveaux E., Vermeersch H., Ma Y., On the Phosphorylation of Deoxyribonucleosides and the Protection of Deoxyguanosine, 10.1002/bscb.19850941109
  18. Turner A. F., Khorana H. G., Studies on Polynucleotides. VI.1Experiments on the Chemical Polymerization of Mononucleotides. Oligonucleotides Derived from Thymidine-3' Phosphate2, 10.1021/ja01526a051
  19. Khorana H. G., Vizsolyi J. P., Studies on Polynucleotides. VIII.1Experiments on the Polymerization of Mononucleotides. Improved Preparation and Separation of Linear Thymidine Polynucleotides. Synthesis of Corresponding Members Terminated in Deoxycytidine Residues2, 10.1021/ja01464a037
  20. Ralph R. K., Connors W. J., Schaller H., Khorana H. G., Studies on Polynucleotides. XVIII.1Experiments on the Polymerization of Mononucleotides. The Synthesis and Characterization of Deoxyguanosine Oligonucleotides2, 10.1021/ja00896a018
  21. Falk W., Tamm Ch., Nucleoside und Nucleotide. Teil 3. �ber die Polykondensation von Thymidin-3?-phosphat nach der Triestermethode, 10.1002/hlca.19720550611
  22. Sherwood E., Joshi A., Oró J., Cyanamide mediated syntheses under plausible primitive earth conditions : II. The Polymerization of Deoxythymidine 5′-Triphosphate, 10.1007/bf01764595
  23. Iigo Masaaki, Hoshi Akio, Mechanism of potentiation of antitumor activity of 5-fluorouracil against adenocarcinoma 755 by L-cysteine, 10.1016/0006-2952(86)90238-8
  24. Iigo M., Hoshi A., Kitagawa H., Potentiation of the chemotherapeutic action of tegafur against solid adenocarcinoma 755 by combination with l-cystine, 10.1007/bf00389232
  25. Iigo Masaaki, Nakajima Yoko, Hoshi Akio, De Clercq Erik, Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil and ftorafur against adenocarcinoma 755 in mice, 10.1016/0277-5379(87)90277-x
  26. Iigo M., Jpn. J. Cancer Res. (Gann), 78, 409 (1987)
  27. Jenny Hsu Chin-Yi, Don Dennis, Oger Jones, Synthesis and Physical Characterization of Bis 3′→5′ Cyclic Dinucleotides (NpNp): RNA Polymerase Inhibitors, 10.1080/07328318508056168