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Differential-effects of Cerulein and Bombesin On the Ethanol Intake in the Rat

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Gewiss, M. Heidbreder, C. De Witte, Philippe [UCL]

Male Wistar rats were allowed to drink either water or water mixed with ethyl alcohol (4%, 8% and 12%) as part of a water-deprived procedure. The decapeptide caerulein (1,3 and 6-mu-g/kg i.p.), a cholecystokinin analog, decreased the intake of ethanol while the consumption of tap water remained unchanged in a choice paradigm. The addition of quinine (a bitter substance) in drinking bottles did not significantly modify the fluid consumption while the i.p. injection of caerulein produced a significant decrease in the consumption of the saccharin containing bottle. The i.p. administration of bombesin (10 and 20-mu-g/kg) failed to modify the intake of water or ethanol solution in water-deprived animals. Interpretations are given in terms of the action of the cholecystokinin analog on differences in the taste intensity induced by the beverage or in terms of a direct consequence of the caerulein-induced decreased gastric emptying effect leading to an accumulation of ethanol in the gut.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1991
Language Anglais
Journal information "Archives Internationales de Physiologie et de Biochimie" - Vol. 99, no. 2, p. 151-153 (1991)
Peer reviewed yes
Publisher Swets Zeitlinger Publishers (Lisse)
issn 0003-9799
Publication status Publié
Affiliation UCL
Links
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Bibliographic reference Gewiss, M. ; Heidbreder, C. ; De Witte, Philippe. Differential-effects of Cerulein and Bombesin On the Ethanol Intake in the Rat. In: Archives Internationales de Physiologie et de Biochimie, Vol. 99, no. 2, p. 151-153 (1991)
Permanent URL http://hdl.handle.net/2078.1/51051