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Minor myeloid component in Ph chromosome‐positive acute lymphoblastic leukaemia: correlation with cytogenetic pattern and implication for poor response to therapy

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Cuneo, Antonio Demuynck, Hilde Ferrant, Augustin [UCL] Louwagie, Andries Doyen, Chantal [UCL] Michaux, Jean-Louis [UCL] Van den Berghe, Herman

Morphological, immunological and cytogenetic features were studied in 27 adults presenting with Ph chromosome-positive acute lymphoblastic leukaemia (ALL), in correlation with clinical outcome. Twenty patients (group 1) were diagnosed as having typical ALL according to the FAB criteria supported by immunological findings. Less than 1% blast cells with azurophilic granules were detected in all cases. Myeloid cytochemistry, i.e. peroxidase and Sudan black-B stain, was negative in all cases. A minor phenotype deviation consisting of the expression of the CD13 myeloid-associated marker was detected in two patients. In seven patients (group 2) a diagnosis of ALL with a minor myeloid component was made because of the presence of a majority of lymphoid blasts and of 5-15% blast cells with morphological cytochemical and immunological features of the myeloid lineage. Abnormal metaphases were found in 6/20 (30%) patients in group 1, compared with 7/7 (100%) patients in group 2. All patients were treated by antilymphoid regimens; however, complete remission was achieved in 17/20 (85%) patients in group 1 versus 1/7 (14.3%) patients in group 2. Median survival was 16 months, range <1-120+ in group 1 and 9 months, range <1-15 in group 2. It is concluded that morphological, immunological and cytogenetic studies allow for the recognition of two cytological subsets of Ph+ ALL. The presence of a minor myeloid component in otherwise typical Ph chromosome-positive ALL may be associated with a distinct cytogenetic pattern and poor responses to antilymphoid therapy.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Language Anglais
Journal information "British Journal of Haematology" - Vol. 87, no. 3, p. 515-522 (1994)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 0007-1048
e-issn 1365-2141
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hématologie
UCL - (MGD) Service d'hématologie
Keywords Ph+ leukaemia ; Hybrid acute leukaemia ; ALL ; Cytogenetic patterns ; Clinical outcome
Links
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Bibliographic reference Cuneo, Antonio ; Demuynck, Hilde ; Ferrant, Augustin ; Louwagie, Andries ; Doyen, Chantal ; et. al. Minor myeloid component in Ph chromosome‐positive acute lymphoblastic leukaemia: correlation with cytogenetic pattern and implication for poor response to therapy. In: British Journal of Haematology, Vol. 87, no. 3, p. 515-522 (1994)
Permanent URL http://hdl.handle.net/2078.1/48826