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Transplacental Cocaine Exposure: A Mouse Model Demonstrating Neuroanatomic and Behavioral Abnormalities

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Kosofsky, Barry E. Wilkins, Aaron S. Gressens, Pierre Evrard, Philippe [UCL]

Between 10% and 15% of infants born in urban America today have been exposed to cocaine in utero. clinical studies have suggested that impairment of brain growth is the single best marker of significant prenatal cocaine exposure, and postnatal developmental compromised seen in a subset of affected children as a consequence of that exposure. We have developed an animal model, in mice, of prenatal cocaine exposure that has allowed us to dissociate the direct effects of cocaine in altering fetal development from the indirect effects associated with cocaine-induced malnutrition. We find that transplacental cocaine exposure independently impairs fetal brain and body growth and results in behavioural deficits and permanent alterations in neocortical cytoarchitecture in exposed offspring.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Language Anglais
Journal information "Journal of Child Neurology" - Vol. 9, no. 3, p. 234-241 (1994)
Peer reviewed yes
Publisher Sage Publications, Inc. (Thousand Oaks)
issn 0883-0738
e-issn 1708-8283
Publication status Publié
Affiliation UCL - MD/NOPS - Département de neurologie et de psychiatrie
Links
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Bibliographic reference Kosofsky, Barry E. ; Wilkins, Aaron S. ; Gressens, Pierre ; Evrard, Philippe. Transplacental Cocaine Exposure: A Mouse Model Demonstrating Neuroanatomic and Behavioral Abnormalities. In: Journal of Child Neurology, Vol. 9, no. 3, p. 234-241 (1994)
Permanent URL http://hdl.handle.net/2078.1/48662